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Suppliers for
CBL0137 hydrochloride
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Properties | CAS |
1197397-89-9 |
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3 Registered suppliers
Molecular Formula: C21H24N2O2 ? HCl
Molecular Formula: C21H24N2O2 ? HCl
Description : NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) is a protein complex that controls transcription of DNA, cytokine production and cell survival. CBL0137 activates p53 and inhibits NF-kB with EC50s of 0.37 μM and 0.47 μM in the cell-based p53 and NF-kB reporter assays, respectively. It functionally inactivates the facilitates chromatin transcription complex, driving the effects on p53 and NF-κB and promoting cancer cell death. - Molecular Weight :372.9
- Purity :≥98%
Molecular Formula : C21H24N2O2·HCl Canonical SMILES : CC(C1=CC=C2C(C(C=C(C(C)=O)C=C3)=C3N2CCNC(C)C)=C1)=O.Cl InChI : InChI=1S/C21H24N2O2.ClH/c1-13(2)22-9-10-23-20-7-5-16(14(3)24)11-18(20)19-12-17(15(4)25)6-8-21(19)23;/h5-8,11-13,22H,9-10H2,1-4H3;1H InChIKey : IXRKBBVMDMKAEB-UHFFFAOYSA-N Appearance : Crystalline Solid Synonyms : CBLC137; CBL-0137; Curaxin 137
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Last update 2024-05-10
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