BGC > Produktsuche > CBL0137 hydrochloride | 1197397-89-9

Molecular Formula: C21H24N2O2 ? HCl

Description:
NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) is a protein complex that controls transcription of DNA, cytokine production and cell survival. CBL0137 activates p53 and inhibits NF-kB with EC50s of 0.37 μM and 0.47 μM in the cell-based p53 and NF-kB reporter assays, respectively. It functionally inactivates the facilitates chromatin transcription complex, driving the effects on p53 and NF-κB and promoting cancer cell death.

• Molecular Weight:372.9
• Purity:≥98%

Molecular Formula:
C21H24N2O2·HCl
Canonical SMILES:
CC(C1=CC=C2C(C(C=C(C(C)=O)C=C3)=C3N2CCNC(C)C)=C1)=O.Cl
InChI:
InChI=1S/C21H24N2O2.ClH/c1-13(2)22-9-10-23-20-7-5-16(14(3)24)11-18(20)19-12-17(15(4)25)6-8-21(19)23;/h5-8,11-13,22H,9-10H2,1-4H3;1H
InChIKey:
IXRKBBVMDMKAEB-UHFFFAOYSA-N
Appearance:
Crystalline Solid
Synonyms:
CBLC137; CBL-0137; Curaxin 137