BGC > Product Search > Ketotifen fumarate

Characters	White to brownish-yellow,fine,crystalline powder.
Identification	TLC IR spectrum
Solubility	Sparingly soluble in water,slightly soluble in methanol,very slightly soluble in acetonifrile
Clarity and colour of solution	Clear and not more than Y4,BY4,B4
Loss on drying	Not more than 0.5%
Sulphated ash	Not more than 0.1%
Related substances(HPLC)
Impurity A	Not more than 0.2%
Impurity G	Not more than 0.2%
Single unknown impurity	Not more than 0.10%
Total impurities	Not more than 0.5%
Residual solvents	Acetone ≤ 5000PPM
Methanol	≤ 500PPM
Assay (potentiometic titration) Calculated on the dried basis	Between 98.5% and 101.0%

Characters	White to brownish-yellow,fine,crystalline powder.
Identification	TLC IR spectrum
Solubility	Sparingly soluble in water,slightly soluble in methanol,very slightly soluble in acetonifrile
Clarity and colour of solution	Clear and not more than Y4,BY4,B4
Loss on drying	Not more than 0.5%
Sulphated ash	Not more than 0.1%
Related substances(HPLC)
Impurity A	Not more than 0.2%
Impurity G	Not more than 0.2%
Single unknown impurity	Not more than 0.10%
Total impurities	Not more than 0.5%
Residual solvents	Acetone ≤ 5000PPM
Methanol	≤ 500PPM
Assay (potentiometic titration) Calculated on the dried basis	Between 98.5% and 101.0%

Characters	White to brownish-yellow,fine,crystalline powder.
Identification	TLC IR spectrum
Solubility	Sparingly soluble in water,slightly soluble in methanol,very slightly soluble in acetonifrile
Clarity and colour of solution	Clear and not more than Y4,BY4,B4
Loss on drying	Not more than 0.5%
Sulphated ash	Not more than 0.1%
Related substances(HPLC)
Impurity A	Not more than 0.2%
Impurity G	Not more than 0.2%
Single unknown impurity	Not more than 0.10%
Total impurities	Not more than 0.5%
Residual solvents	Acetone ≤ 5000PPM
Methanol	≤ 500PPM
Assay (potentiometic titration) Calculated on the dried basis	Between 98.5% and 101.0%

Characters	White to brownish-yellow,fine,crystalline powder.
Identification	TLC IR spectrum
Solubility	Sparingly soluble in water,slightly soluble in methanol,very slightly soluble in acetonifrile
Clarity and colour of solution	Clear and not more than Y4,BY4,B4
Loss on drying	Not more than 0.5%
Sulphated ash	Not more than 0.1%
Related substances(HPLC)
Impurity A	Not more than 0.2%
Impurity G	Not more than 0.2%
Single unknown impurity	Not more than 0.10%
Total impurities	Not more than 0.5%
Residual solvents	Acetone ≤ 5000PPM
Methanol	≤ 500PPM
Assay (potentiometic titration) Calculated on the dried basis	Between 98.5% and 101.0%

Molecular Formula: C23H23NO5S
Molecular Weight: 425.5
Hazard Symbols: Xn,T
WGKGermany: 3
HS Code: 29349990

Appearance	White or Brownish-yellow, fine, crystalline powder
Solubility	Sparingly soluble in water, slightly soluble in methanol, very slightly soluble in aceton.
Clarity and color of solution	Clear and not more than Y4BY4B4
Sulphated ash,%	≤ 0.1
Loss on drying,%	≤ 0.5
Related substances (HPLC), %
Impurity A	Not more than 0.2
Impurity G	Not more than 0.2
Single unknown impurity	Not more than 0.1
Total Impurity	Not more than 0.5
Assay, %	98.5~101.0

Appearance	White or Brownish-yellow, fine, crystalline powder
Solubility	Sparingly soluble in water, slightly soluble in methanol, very slightly soluble in aceton.
Clarity and color of solution	Clear and not more than Y4BY4B4
Sulphated ash,%	≤ 0.1
Loss on drying,%	≤ 0.5
Related substances (HPLC), %
Impurity A	Not more than 0.2
Impurity G	Not more than 0.2
Single unknown impurity	Not more than 0.1
Total Impurity	Not more than 0.5
Assay, %	98.5~101.0

Appearance	White or Brownish-yellow, fine, crystalline powder
Solubility	Sparingly soluble in water, slightly soluble in methanol, very slightly soluble in aceton.
Clarity and color of solution	Clear and not more than Y4BY4B4
Sulphated ash,%	≤ 0.1
Loss on drying,%	≤ 0.5
Related substances (HPLC), %
Impurity A	Not more than 0.2
Impurity G	Not more than 0.2
Single unknown impurity	Not more than 0.1
Total Impurity	Not more than 0.5
Assay, %	98.5~101.0

Description :
Ketotifen is a second-generation noncompetitive H1-antihistamine and mast cell stabilizer. It is most commonly sold as a salt with fumaric acid, ketotifen fumarate, and is available in two forms. In its ophthalmic form, it is used to treat allergic conjunctivitis,or the itchy red eyes caused by allergies. In its oral form, it is used to preventasthma attacks.

• Molecular Weight :425.5
• Boiling Point :250-263 °C(lit.)
• Melting Point :> 191°C (dec.)
• Purity :> 98%

Molecular Formula :
C19H19NOS.C4H4O4
Canonical SMILES :
CN1CCC(=C2C3=C(C(=O)CC4=CC=CC=C42)SC=C3)CC1.C(=CC(=O)O)C(=O)O
InChI :
InChI=1S/C19H19NOS.C4H4O4/c1-20-9-6-13(7-10-20)18-15-5-3-2-4-14(15)12-17(21)19-16(18)8-11-22-19;5-3(6)1-2-4(7)8/h2-5,8,11H,6-7,9-10,12H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1+
InChIKey :
YNQQEYBLVYAWNX-WLHGVMLRSA-N
Solubility :
In Vitro: DMSO : ≥ 100 mg/mL(235.02 mM) H2O : 16.67 mg/mL(39.18 mM;Need ultrasonic) In Vivo: 1.Add each solvent one by one:PBS Solubility: 37.5 mg/mL (88.13 mM); Clear solution; Need ultrasonic 2.Add each solvent one by one:10% DMSO > > 40%PEG300 > > 5%Tween-80 > > 45% saline Solubility: ≥ 2.5 mg/mL (5.88 mM); Clear solution 3.Add each solvent one by one:10% DMSO > > 90% (20%SBE-β-CDin saline) Solubility: ≥ 2.5 mg/mL (5.88 mM); Clear solution
Appearance :
Off-white crystalline powder
Application :
Antipruritics
Storage : 4°C, sealed storage, away from moisture * In solvent : -80°C, 6 months -20°C, 1 month (sealed storage, away from moisture)
Synonyms :
Zaditen; Zaditor

More details are to be found here

Description :
Ketotifen is a second-generation noncompetitive H1-antihistamine and mast cell stabilizer. It is most commonly sold as a salt with fumaric acid, ketotifen fumarate, and is available in two forms. In its ophthalmic form, it is used to treat allergic conjunctivitis,or the itchy red eyes caused by allergies. In its oral form, it is used to preventasthma attacks.

• Molecular Weight :425.5
• Boiling Point :250-263 °C(lit.)
• Melting Point :> 191°C (dec.)
• Purity :> 98%

Molecular Formula :
C19H19NOS.C4H4O4
Canonical SMILES :
CN1CCC(=C2C3=C(C(=O)CC4=CC=CC=C42)SC=C3)CC1.C(=CC(=O)O)C(=O)O
InChI :
InChI=1S/C19H19NOS.C4H4O4/c1-20-9-6-13(7-10-20)18-15-5-3-2-4-14(15)12-17(21)19-16(18)8-11-22-19;5-3(6)1-2-4(7)8/h2-5,8,11H,6-7,9-10,12H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1+
InChIKey :
YNQQEYBLVYAWNX-WLHGVMLRSA-N
Solubility :
In Vitro: DMSO : ≥ 100 mg/mL(235.02 mM) H2O : 16.67 mg/mL(39.18 mM;Need ultrasonic) In Vivo: 1.Add each solvent one by one:PBS Solubility: 37.5 mg/mL (88.13 mM); Clear solution; Need ultrasonic 2.Add each solvent one by one:10% DMSO > > 40%PEG300 > > 5%Tween-80 > > 45% saline Solubility: ≥ 2.5 mg/mL (5.88 mM); Clear solution 3.Add each solvent one by one:10% DMSO > > 90% (20%SBE-β-CDin saline) Solubility: ≥ 2.5 mg/mL (5.88 mM); Clear solution
Appearance :
Off-white crystalline powder
Application :
Antipruritics
Storage : 4°C, sealed storage, away from moisture * In solvent : -80°C, 6 months -20°C, 1 month (sealed storage, away from moisture)
Synonyms :
Zaditen; Zaditor

More details are to be found here

Description :
Ketotifen is a second-generation noncompetitive H1-antihistamine and mast cell stabilizer. It is most commonly sold as a salt with fumaric acid, ketotifen fumarate, and is available in two forms. In its ophthalmic form, it is used to treat allergic conjunctivitis,or the itchy red eyes caused by allergies. In its oral form, it is used to preventasthma attacks.

• Molecular Weight :425.5
• Boiling Point :250-263 °C(lit.)
• Melting Point :> 191°C (dec.)
• Purity :> 98%

Molecular Formula :
C19H19NOS.C4H4O4
Canonical SMILES :
CN1CCC(=C2C3=C(C(=O)CC4=CC=CC=C42)SC=C3)CC1.C(=CC(=O)O)C(=O)O
InChI :
InChI=1S/C19H19NOS.C4H4O4/c1-20-9-6-13(7-10-20)18-15-5-3-2-4-14(15)12-17(21)19-16(18)8-11-22-19;5-3(6)1-2-4(7)8/h2-5,8,11H,6-7,9-10,12H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1+
InChIKey :
YNQQEYBLVYAWNX-WLHGVMLRSA-N
Solubility :
In Vitro: DMSO : ≥ 100 mg/mL(235.02 mM) H2O : 16.67 mg/mL(39.18 mM;Need ultrasonic) In Vivo: 1.Add each solvent one by one:PBS Solubility: 37.5 mg/mL (88.13 mM); Clear solution; Need ultrasonic 2.Add each solvent one by one:10% DMSO > > 40%PEG300 > > 5%Tween-80 > > 45% saline Solubility: ≥ 2.5 mg/mL (5.88 mM); Clear solution 3.Add each solvent one by one:10% DMSO > > 90% (20%SBE-β-CDin saline) Solubility: ≥ 2.5 mg/mL (5.88 mM); Clear solution
Appearance :
Off-white crystalline powder
Application :
Antipruritics
Storage : 4°C, sealed storage, away from moisture * In solvent : -80°C, 6 months -20°C, 1 month (sealed storage, away from moisture)
Synonyms :
Zaditen; Zaditor

More details are to be found here

Description :
Ketotifen is a second-generation noncompetitive H1-antihistamine and mast cell stabilizer. It is most commonly sold as a salt with fumaric acid, ketotifen fumarate, and is available in two forms. In its ophthalmic form, it is used to treat allergic conjunctivitis,or the itchy red eyes caused by allergies. In its oral form, it is used to preventasthma attacks.

• Molecular Weight :425.5
• Boiling Point :250-263 °C(lit.)
• Melting Point :> 191°C (dec.)
• Purity :> 98%

Molecular Formula :
C19H19NOS.C4H4O4
Canonical SMILES :
CN1CCC(=C2C3=C(C(=O)CC4=CC=CC=C42)SC=C3)CC1.C(=CC(=O)O)C(=O)O
InChI :
InChI=1S/C19H19NOS.C4H4O4/c1-20-9-6-13(7-10-20)18-15-5-3-2-4-14(15)12-17(21)19-16(18)8-11-22-19;5-3(6)1-2-4(7)8/h2-5,8,11H,6-7,9-10,12H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1+
InChIKey :
YNQQEYBLVYAWNX-WLHGVMLRSA-N
Solubility :
In Vitro: DMSO : ≥ 100 mg/mL(235.02 mM) H2O : 16.67 mg/mL(39.18 mM;Need ultrasonic) In Vivo: 1.Add each solvent one by one:PBS Solubility: 37.5 mg/mL (88.13 mM); Clear solution; Need ultrasonic 2.Add each solvent one by one:10% DMSO > > 40%PEG300 > > 5%Tween-80 > > 45% saline Solubility: ≥ 2.5 mg/mL (5.88 mM); Clear solution 3.Add each solvent one by one:10% DMSO > > 90% (20%SBE-β-CDin saline) Solubility: ≥ 2.5 mg/mL (5.88 mM); Clear solution
Appearance :
Off-white crystalline powder
Application :
Antipruritics
Storage : 4°C, sealed storage, away from moisture * In solvent : -80°C, 6 months -20°C, 1 month (sealed storage, away from moisture)
Synonyms :
Zaditen; Zaditor

More details are to be found here

Description :
Ketotifen is a second-generation noncompetitive H1-antihistamine and mast cell stabilizer. It is most commonly sold as a salt with fumaric acid, ketotifen fumarate, and is available in two forms. In its ophthalmic form, it is used to treat allergic conjunctivitis,or the itchy red eyes caused by allergies. In its oral form, it is used to preventasthma attacks.

• Molecular Weight :425.5
• Boiling Point :250-263 °C(lit.)
• Melting Point :> 191°C (dec.)
• Purity :> 98%

Molecular Formula :
C19H19NOS.C4H4O4
Canonical SMILES :
CN1CCC(=C2C3=C(C(=O)CC4=CC=CC=C42)SC=C3)CC1.C(=CC(=O)O)C(=O)O
InChI :
InChI=1S/C19H19NOS.C4H4O4/c1-20-9-6-13(7-10-20)18-15-5-3-2-4-14(15)12-17(21)19-16(18)8-11-22-19;5-3(6)1-2-4(7)8/h2-5,8,11H,6-7,9-10,12H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1+
InChIKey :
YNQQEYBLVYAWNX-WLHGVMLRSA-N
Solubility :
In Vitro: DMSO : ≥ 100 mg/mL(235.02 mM) H2O : 16.67 mg/mL(39.18 mM;Need ultrasonic) In Vivo: 1.Add each solvent one by one:PBS Solubility: 37.5 mg/mL (88.13 mM); Clear solution; Need ultrasonic 2.Add each solvent one by one:10% DMSO > > 40%PEG300 > > 5%Tween-80 > > 45% saline Solubility: ≥ 2.5 mg/mL (5.88 mM); Clear solution 3.Add each solvent one by one:10% DMSO > > 90% (20%SBE-β-CDin saline) Solubility: ≥ 2.5 mg/mL (5.88 mM); Clear solution
Appearance :
Off-white crystalline powder
Application :
Antipruritics
Storage : 4°C, sealed storage, away from moisture * In solvent : -80°C, 6 months -20°C, 1 month (sealed storage, away from moisture)
Synonyms :
Zaditen; Zaditor

More details are to be found here

Description :
Ketotifen is a second-generation noncompetitive H1-antihistamine and mast cell stabilizer. It is most commonly sold as a salt with fumaric acid, ketotifen fumarate, and is available in two forms. In its ophthalmic form, it is used to treat allergic conjunctivitis,or the itchy red eyes caused by allergies. In its oral form, it is used to preventasthma attacks.

• Molecular Weight :425.5
• Boiling Point :250-263 °C(lit.)
• Melting Point :> 191°C (dec.)
• Purity :> 98%

Molecular Formula :
C19H19NOS.C4H4O4
Canonical SMILES :
CN1CCC(=C2C3=C(C(=O)CC4=CC=CC=C42)SC=C3)CC1.C(=CC(=O)O)C(=O)O
InChI :
InChI=1S/C19H19NOS.C4H4O4/c1-20-9-6-13(7-10-20)18-15-5-3-2-4-14(15)12-17(21)19-16(18)8-11-22-19;5-3(6)1-2-4(7)8/h2-5,8,11H,6-7,9-10,12H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1+
InChIKey :
YNQQEYBLVYAWNX-WLHGVMLRSA-N
Solubility :
In Vitro: DMSO : ≥ 100 mg/mL(235.02 mM) H2O : 16.67 mg/mL(39.18 mM;Need ultrasonic) In Vivo: 1.Add each solvent one by one:PBS Solubility: 37.5 mg/mL (88.13 mM); Clear solution; Need ultrasonic 2.Add each solvent one by one:10% DMSO > > 40%PEG300 > > 5%Tween-80 > > 45% saline Solubility: ≥ 2.5 mg/mL (5.88 mM); Clear solution 3.Add each solvent one by one:10% DMSO > > 90% (20%SBE-β-CDin saline) Solubility: ≥ 2.5 mg/mL (5.88 mM); Clear solution
Appearance :
Off-white crystalline powder
Application :
Antipruritics
Storage : 4°C, sealed storage, away from moisture * In solvent : -80°C, 6 months -20°C, 1 month (sealed storage, away from moisture)
Synonyms :
Zaditen; Zaditor

More details are to be found here

Description :
Ketotifen is a second-generation noncompetitive H1-antihistamine and mast cell stabilizer. It is most commonly sold as a salt with fumaric acid, ketotifen fumarate, and is available in two forms. In its ophthalmic form, it is used to treat allergic conjunctivitis,or the itchy red eyes caused by allergies. In its oral form, it is used to preventasthma attacks.

• Molecular Weight :425.5
• Boiling Point :250-263 °C(lit.)
• Melting Point :> 191°C (dec.)
• Purity :> 98%

Molecular Formula :
C19H19NOS.C4H4O4
Canonical SMILES :
CN1CCC(=C2C3=C(C(=O)CC4=CC=CC=C42)SC=C3)CC1.C(=CC(=O)O)C(=O)O
InChI :
InChI=1S/C19H19NOS.C4H4O4/c1-20-9-6-13(7-10-20)18-15-5-3-2-4-14(15)12-17(21)19-16(18)8-11-22-19;5-3(6)1-2-4(7)8/h2-5,8,11H,6-7,9-10,12H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1+
InChIKey :
YNQQEYBLVYAWNX-WLHGVMLRSA-N
Solubility :
In Vitro: DMSO : ≥ 100 mg/mL(235.02 mM) H2O : 16.67 mg/mL(39.18 mM;Need ultrasonic) In Vivo: 1.Add each solvent one by one:PBS Solubility: 37.5 mg/mL (88.13 mM); Clear solution; Need ultrasonic 2.Add each solvent one by one:10% DMSO > > 40%PEG300 > > 5%Tween-80 > > 45% saline Solubility: ≥ 2.5 mg/mL (5.88 mM); Clear solution 3.Add each solvent one by one:10% DMSO > > 90% (20%SBE-β-CDin saline) Solubility: ≥ 2.5 mg/mL (5.88 mM); Clear solution
Appearance :
Off-white crystalline powder
Application :
Antipruritics
Storage : 4°C, sealed storage, away from moisture * In solvent : -80°C, 6 months -20°C, 1 month (sealed storage, away from moisture)
Synonyms :
Zaditen; Zaditor

More details are to be found here

Description :
Ketotifen is a second-generation noncompetitive H1-antihistamine and mast cell stabilizer. It is most commonly sold as a salt with fumaric acid, ketotifen fumarate, and is available in two forms. In its ophthalmic form, it is used to treat allergic conjunctivitis,or the itchy red eyes caused by allergies. In its oral form, it is used to preventasthma attacks.

• Molecular Weight :425.5
• Boiling Point :250-263 °C(lit.)
• Melting Point :> 191°C (dec.)
• Purity :> 98%

Molecular Formula :
C19H19NOS.C4H4O4
Canonical SMILES :
CN1CCC(=C2C3=C(C(=O)CC4=CC=CC=C42)SC=C3)CC1.C(=CC(=O)O)C(=O)O
InChI :
InChI=1S/C19H19NOS.C4H4O4/c1-20-9-6-13(7-10-20)18-15-5-3-2-4-14(15)12-17(21)19-16(18)8-11-22-19;5-3(6)1-2-4(7)8/h2-5,8,11H,6-7,9-10,12H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1+
InChIKey :
YNQQEYBLVYAWNX-WLHGVMLRSA-N
Solubility :
In Vitro: DMSO : ≥ 100 mg/mL(235.02 mM) H2O : 16.67 mg/mL(39.18 mM;Need ultrasonic) In Vivo: 1.Add each solvent one by one:PBS Solubility: 37.5 mg/mL (88.13 mM); Clear solution; Need ultrasonic 2.Add each solvent one by one:10% DMSO > > 40%PEG300 > > 5%Tween-80 > > 45% saline Solubility: ≥ 2.5 mg/mL (5.88 mM); Clear solution 3.Add each solvent one by one:10% DMSO > > 90% (20%SBE-β-CDin saline) Solubility: ≥ 2.5 mg/mL (5.88 mM); Clear solution
Appearance :
Off-white crystalline powder
Application :
Antipruritics
Storage : 4°C, sealed storage, away from moisture * In solvent : -80°C, 6 months -20°C, 1 month (sealed storage, away from moisture)
Synonyms :
Zaditen; Zaditor

More details are to be found here