BGC > Product Search > Flavopiridol hydrochloride | 131740-09-5

Molecular Formula: C21H21Cl2NO5
Molecular Weight: 438.3
Hazard Symbols: Xn
WGKGermany: 3

Molecular Formula: C21H21Cl2NO5
Molecular Weight: 438.3
Hazard Symbols: Xn
WGKGermany: 3

Molecular Formula: C21H21Cl2NO5
Molecular Weight: 438.3
Hazard Symbols: Xn
WGKGermany: 3

Description :
Flavopiridol hydrochloride competes with ATP to inhibit CDKs including CDK1, CDK2, CDK4 and CDK6 with IC50 of ~ 40 nM. It is 7.5-fold more selective for CDK1/2/4/6 than CDK7. Flavopiridol is initially found to inhibit EGFR and PKA.

• Molecular Weight :438.3
• Boiling Point :603.6ºC at 760 mmHg
• Melting Point :169.5-170ºC
• Purity :> 98%

Molecular Formula :
C21H20ClNO5.HCl
Canonical SMILES :
CN1CCC(C(C1)O)C2=C(C=C(C3=C2OC(=CC3=O)C4=CC=CC=C4Cl)O)O.Cl
InChI :
InChI=1S/C21H20ClNO5.ClH/c1-23-7-6-12(17(27)10-23)19-14(24)8-15(25)20-16(26)9-18(28-21(19)20)11-4-2-3-5-13(11)22;/h2-5,8-9,12,17,24-25,27H,6-7,10H2,1H3;1H/t12-,17+;/m0./s1
InChIKey :
LGMSNQNWOCSPIK-LWHGMNCYSA-N
Solubility :
In Vitro: H2O : ≥ 20 mg/mL(45.63 mM) DMF : 7.69 mg/mL(17.55 mM;Need ultrasonic)
Appearance :
Light yellow to khaki (Solid)
Storage : 4°C, sealed storage, away from moisture * In solvent : -80°C, 6 months -20°C, 1 month (sealed storage, away from moisture)
Synonyms :
NSC 649890 HCl; NSC649890 HCl; NSC-649890 HCl

More details are to be found here

Smile code:
O=C1C=C(C2=CC=CC=C2Cl)OC3=C1C(O)=CC(O)=C3[C@@H]4[C@H](O)CN(C)CC4.[H]Cl
MDL Number:
MFCD26792554
Purity :
98%
Available in stock:
10.092 g

More details are to be found here

Smile code:
O=C1C=C(C2=CC=CC=C2Cl)OC3=C1C(O)=CC(O)=C3[C@@H]4[C@H](O)CN(C)CC4.[H]Cl
MDL Number:
MFCD26792554
Purity :
98%
Available in stock:
10.092 g

More details are to be found here

Smile code:
O=C1C=C(C2=CC=CC=C2Cl)OC3=C1C(O)=CC(O)=C3[C@@H]4[C@H](O)CN(C)CC4.[H]Cl
MDL Number:
MFCD26792554
Purity :
98%
Available in stock:
10.092 g

More details are to be found here

Smile code:
O=C1C=C(C2=CC=CC=C2Cl)OC3=C1C(O)=CC(O)=C3[C@@H]4[C@H](O)CN(C)CC4.[H]Cl
MDL Number:
MFCD26792554
Purity :
98%
Available in stock:
10.092 g

More details are to be found here