BGC > Product Search > 3-(6-{[1-(2,2-Difluorobenzo[1,3]dioxol-5-yl)-cyclopropanecarbonyl]-amino}-3-methyl-pyridin-2-yl)benzoic acid | 936727-05-8

Molecular Formula: C24H18F2N2O5
Molecular Weight: 452.4069264

Molecular Formula: C24H18F2N2O5
Molecular Weight: 452.4069264

Molecular Formula: C24H18F2N2O5
Molecular Weight: 452.4069264

Molecular Formula: C24H18F2N2O5
Molecular Weight: 452.4069264

Description :
Lumacaftor is the second investigational oral candidate compound for the treatment of cystic fibrosis (CF). Lumacaftor may act to restore the function of the cystic fibrosis transmembrane conductance regulator (CFTR) protein, the defective cell membrane protein responsible for the progression of CF. Lumacaftor defects in the CFTR protein affect the transport of chloride and other ions across cells, and lead to the accumulation of thick, sticky mucus in the lungs of patients with CF. This mucus fosters chronic infection and inflammation, and results in irreversible lung damage.

• Molecular Weight :452.41
• Purity :≥98%

Molecular Formula :
C24H18F2N2O5
Canonical SMILES :
CC1=C(N=C(C=C1)NC(=O)C2(CC2)C3=CC4=C(C=C3)OC(O4)(F)F)C5=CC(=CC=C5)C(=O)O
InChI :
InChI=1S/C24H18F2N2O5/c1-13-5-8-19(27-20(13)14-3-2-4-15(11-14)21(29)30)28-22(31)23(9-10-23)16-6-7-17-18(12-16)33-24(25,26)32-17/h2-8,11-12H,9-10H2,1H3,(H,29,30)(H,27,28,31)
InChIKey :
UFSKUSARDNFIRC-UHFFFAOYSA-N
Synonyms :
VX-809; VX809; VX 809; VRT 826809; VRT826809; VRT-826809

More details are to be found here

Purity : 98%
Smile code : O=C(O)C1=CC=CC(C2=NC(NC(C3(C4=CC=C(OC(F)(F)O5)C5=C4)CC3)=O)=CC=C2C)=C1
MDL Number : MFCD16659051
MolFormula : C24H18F2N2O5
MolWeight : 452.4069
Available in stock : 241.451

More details are to be found here

Smile code:
O=C(O)C1=CC=CC(C2=NC(NC(C3(C4=CC=C(OC(F)(F)O5)C5=C4)CC3)=O)=CC=C2C)=C1
MDL Number:
MFCD16659051
Purity :
98%
Available in stock:
175.089 g

More details are to be found here

Smile code:
O=C(O)C1=CC=CC(C2=NC(NC(C3(C4=CC=C(OC(F)(F)O5)C5=C4)CC3)=O)=CC=C2C)=C1
MDL Number:
MFCD16659051
Purity :
98%
Available in stock:
175.089 g

More details are to be found here