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BGC > Product Search > Neratinib | 698387-09-6
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Suppliers for CAS

698387-09-6



 

Properties

CAS   698387-09-6 
Formula   C30H29ClN6O3 

Structure

13 Registered suppliers

Amadis Chemical Company Limited P.R.China
rd Neratinib   CD details
Hangzhou Meite Industry Co., Ltd (Hangzhou Meite Chemical Co., Ltd) P.R.China
rd Neratinib  

More details are to be found here
Capot Chemical Co., Ltd. P.R.China
rd Neratinib   CD details
Leap Chem Co., Ltd P.R.China
rd Neratinib   CD details
Guangzhou Topwork Chemical Co., Ltd. P.R.China
rd Neratinib  
Molecular Formula: C30H29ClN6O3
Molecular Weight: 557.04266
HS Code: 29334900
Aea.ltd P.R.China
rd Neratinib  
Molecular Formula: C30H29ClN6O3
Molecular Weight: 557.04266
HS Code: 29334900
Hangzhou Zhongqi Chem Co., Ltd P.R.China
rd (2E)-N-(4-((3-chloro-4-((pyridin-2-yl)methoxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-4-(dimethylamino)but-2-enamide  
Molecular Formula: C30H29ClN6O3
Molecular Weight: 557.04266
HS Code: 29334900
Finetech Industry Limited P.R.China
rd (2E)-N-(4-((3-chloro-4-((pyridin-2-yl)methoxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-4-(dimethylamino)but-2-enamide   CD details
Skyrun Industrial Co., Ltd. P.R.China
rd Neratinib  

More details are to be found here
BOC Sciences USA
rd Neratinib   CD details
Chemos GmbH & Co. KG Germany
rd Neratinib  
Description :
Neratinib, also known as HKI-272 or PB272, is an orally available, 6,7-disubstituted-4-anilinoquinoline-3-carbonitrile irreversible inhibitor of the HER-2 receptor tyrosine kinase with potential antineoplastic activity. Neratinib binds to the HER-2 receptor irreversibly, thereby reducing autophosphorylation in cells, apparently by targeting a cysteine residue in the ATP-binding pocket of the receptor. Treatment of cells with this agent results in inhibition of downstream signal transduction events and cell cycle regulatory pathways; arrest at the G1-S (Gap 1/DNA synthesis)-phase transition of the cell division cycle; and ultimately decreased cellular proliferation. Neratinib also inhibits the epidermal growth factor receptor (EGFR) kinase and the proliferation of EGFR-dependent cells.
  • Molecular Weight :557.051
  • Melting Point :185-187 °C
  • Purity :> 98%
Molecular Formula :
C30H29ClN6O3
Canonical SMILES :
CCOC1=C(C=C2C(=C1)N=CC(=C2NC3=CC(=C(C=C3)OCC4=CC=CC=N4)Cl)C#N)NC(=O)C=CCN(C)C
InChI :
InChI=1S/C30H29ClN6O3/c1-4-39-28-16-25-23(15-26(28)36-29(38)9-7-13-37(2)3)30(20(17-32)18-34-25)35-21-10-11-27(24(31)14-21)40-19-22-8-5-6-12-33-22/h5-12,14-16,18H,4,13,19H2,1-3H3,(H,34,35)(H,36,38)/b9-7+
InChIKey :
JWNPDZNEKVCWMY-VQHVLOKHSA-N
Appearance :
Solid powder
Synonyms :
HKI-272; HKI 272; HKI272; PB-272; PB 272; PB 272.
More details are to be found here
BuGuCh & Partners Germany
rd Neratinib  
Description :
Neratinib, also known as HKI-272 or PB272, is an orally available, 6,7-disubstituted-4-anilinoquinoline-3-carbonitrile irreversible inhibitor of the HER-2 receptor tyrosine kinase with potential antineoplastic activity. Neratinib binds to the HER-2 receptor irreversibly, thereby reducing autophosphorylation in cells, apparently by targeting a cysteine residue in the ATP-binding pocket of the receptor. Treatment of cells with this agent results in inhibition of downstream signal transduction events and cell cycle regulatory pathways; arrest at the G1-S (Gap 1/DNA synthesis)-phase transition of the cell division cycle; and ultimately decreased cellular proliferation. Neratinib also inhibits the epidermal growth factor receptor (EGFR) kinase and the proliferation of EGFR-dependent cells.
  • Molecular Weight :557.051
  • Melting Point :185-187 °C
  • Purity :> 98%
Molecular Formula :
C30H29ClN6O3
Canonical SMILES :
CCOC1=C(C=C2C(=C1)N=CC(=C2NC3=CC(=C(C=C3)OCC4=CC=CC=N4)Cl)C#N)NC(=O)C=CCN(C)C
InChI :
InChI=1S/C30H29ClN6O3/c1-4-39-28-16-25-23(15-26(28)36-29(38)9-7-13-37(2)3)30(20(17-32)18-34-25)35-21-10-11-27(24(31)14-21)40-19-22-8-5-6-12-33-22/h5-12,14-16,18H,4,13,19H2,1-3H3,(H,34,35)(H,36,38)/b9-7+
InChIKey :
JWNPDZNEKVCWMY-VQHVLOKHSA-N
Appearance :
Solid powder
Synonyms :
HKI-272; HKI 272; HKI272; PB-272; PB 272; PB 272.
More details are to be found here
Santa Cruz Biotechnology, Inc. USA
rd Neratinib  
Description :
Neratinib, also known as HKI-272 or PB272, is an orally available, 6,7-disubstituted-4-anilinoquinoline-3-carbonitrile irreversible inhibitor of the HER-2 receptor tyrosine kinase with potential antineoplastic activity. Neratinib binds to the HER-2 receptor irreversibly, thereby reducing autophosphorylation in cells, apparently by targeting a cysteine residue in the ATP-binding pocket of the receptor. Treatment of cells with this agent results in inhibition of downstream signal transduction events and cell cycle regulatory pathways; arrest at the G1-S (Gap 1/DNA synthesis)-phase transition of the cell division cycle; and ultimately decreased cellular proliferation. Neratinib also inhibits the epidermal growth factor receptor (EGFR) kinase and the proliferation of EGFR-dependent cells.
  • Molecular Weight :557.051
  • Melting Point :185-187 °C
  • Purity :> 98%
Molecular Formula :
C30H29ClN6O3
Canonical SMILES :
CCOC1=C(C=C2C(=C1)N=CC(=C2NC3=CC(=C(C=C3)OCC4=CC=CC=N4)Cl)C#N)NC(=O)C=CCN(C)C
InChI :
InChI=1S/C30H29ClN6O3/c1-4-39-28-16-25-23(15-26(28)36-29(38)9-7-13-37(2)3)30(20(17-32)18-34-25)35-21-10-11-27(24(31)14-21)40-19-22-8-5-6-12-33-22/h5-12,14-16,18H,4,13,19H2,1-3H3,(H,34,35)(H,36,38)/b9-7+
InChIKey :
JWNPDZNEKVCWMY-VQHVLOKHSA-N
Appearance :
Solid powder
Synonyms :
HKI-272; HKI 272; HKI272; PB-272; PB 272; PB 272.
More details are to be found here
Detailed information on the suppliers of Neratinib

Properties:

... more properties and specification on Neratinib
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