BGC > Product Search > Telaprevir | 402957-28-2

Molecular Formula: C36H53N7O6
Molecular Weight: 679.85
HS Code: 29339900

Molecular Formula: C36H53N7O6
Molecular Weight: 679.85
HS Code: 29339900

Molecular Formula: C36H53N7O6
Molecular Weight: 679.85
HS Code: 29339900

Molecular Formula: C36H53N7O6
Molecular Weight: 679.85
HS Code: 29339900

Molecular Formula: C36H53N7O6
Molecular Weight: 679.85
HS Code: 29339900

Molecular Formula: C36H53N7O6
Molecular Weight: 679.85
HS Code: 29339900

Molecular Formula: C36H53N7O6
Molecular Weight: 679.85
HS Code: 29339900

Description :
Labelled Telaprevir. VX-950 is a potent, selective, peptidomimetic inhibitor of the hepatitis C virus (HCV) NS3-4A serine protease, and it demonstrated excellent antiviral activity both in genotype 1b HCV replicon cells (50% inhibitory concentration [IC50] = 354 nM) and in human fetal hepatocytes infected with genotype 1a HCV-positive patient sera (IC50 = 280 nM). VX-950 forms a covalent but reversible complex with the genotype 1a HCV NS3-4A protease in a slow-on, slow-off process with a steady-state inhibition constant (K(i)*) of 7 nM. Dissociation of the covalent enzyme-inhibitor complex of VX-950 and genotype 1a HCV protease has a half-life of almost an hour. A > 4-log10 reduction in the HCV RNA levels was observed after a 2-week incubation of replicon cells with VX-950, with no rebound of viral RNA observed after withdrawal of the inhibitor. In several animal species, VX-950 exhibits a favorable pharmacokinetic profile with high exposure in the liver. In a recently developed HCV protease mouse model, VX-950 showed excellent inhibition of HCV NS3-4A protease activity in the liver.

• Molecular Weight :683.87
• Melting Point :116-123°C
• Purity :> 98%

Molecular Formula :
C36H49D4N7O6
Canonical SMILES :
CCCC(C(=O)C(=O)NC1CC1)NC(=O)C2C3CCCC3CN2C(=O)C(C(C)(C)C)NC(=O)C(C4CCCCC4)NC(=O)C5=NC=CN=C5
InChI :
InChI=1S/C36H53N7O6/c1-5-10-25(29(44)34(48)39-23-15-16-23)40-33(47)28-24-14-9-13-22(24)20-43(28)35(49)30(36(2,3)4)42-32(46)27(21-11-7-6-8-12-21)41-31(45)26-19-37-17-18-38-26/h17-19,21-25,27-28,30H,5-16,20H2,1-4H3,(H,39,48)(H,40,47)(H,41,45)(H,42,46)/t22-,24-,25-,27-,28-,30+/m0/s1/i15D2,16D2
InChIKey :
BBAWEDCPNXPBQM-WSZQYWDLSA-N
Solubility :
Soluble in Chloroform, Methanol (Slightly)
Appearance :
Pale Yellow to Light Yellow Waxy Solid
Storage : Store at-20°C Freezer, Under Inert Atmosphere
Synonyms :
(1S,3aR,6aS)-(2S)-2-Cyclohexyl-N-(2-pyrazinylcarbonyl)glycyl-3-methyl-L-valyl-N-[(1S)-1-[2-[(cyclopropyl-d4)amino]-2-oxoacetyl]butyl]octahydrocyclopenta[c]pyrrole-1-carboxamide; LY 570310-d4; MP 424-d4; VRT 111950-d4; VX 950-d4

More details are to be found here

Purity : 97%
Smile code : O=C(N([C@@H]1C(N[C@H](C(C(NC2CC2)=O)=O)CCC)=O)C[C@@]3(CCC[C@@]31[H])[H])[C@@H](NC([C@@H](NC(C4=NC=CN=C4)=O)C5CCCCC5)=O)C(C)(C)C
MDL Number : MFCD11616089
MolFormula : C36H53N7O6
MolWeight : 679.8493
Available in stock : 0.409

More details are to be found here

Smile code:
O=C(N([C@@H]1C(N[C@H](C(C(NC2CC2)=O)=O)CCC)=O)C[C@@]3(CCC[C@@]31[H])[H])[C@@H](NC([C@@H](NC(C4=NC=CN=C4)=O)C5CCCCC5)=O)C(C)(C)C
MDL Number:
MFCD11616089
Purity :
97%
Available in stock:
10.306 g

More details are to be found here

Smile code:
O=C(N([C@@H]1C(N[C@H](C(C(NC2CC2)=O)=O)CCC)=O)C[C@@]3(CCC[C@@]31[H])[H])[C@@H](NC([C@@H](NC(C4=NC=CN=C4)=O)C5CCCCC5)=O)C(C)(C)C
MDL Number:
MFCD11616089
Purity :
97%
Available in stock:
10.306 g

More details are to be found here

Smile code:
O=C(N([C@@H]1C(N[C@H](C(C(NC2CC2)=O)=O)CCC)=O)C[C@@]3(CCC[C@@]31[H])[H])[C@@H](NC([C@@H](NC(C4=NC=CN=C4)=O)C5CCCCC5)=O)C(C)(C)C
MDL Number:
MFCD11616089
Purity :
97%
Available in stock:
10.306 g

More details are to be found here

Smile code:
O=C(N([C@@H]1C(N[C@H](C(C(NC2CC2)=O)=O)CCC)=O)C[C@@]3(CCC[C@@]31[H])[H])[C@@H](NC([C@@H](NC(C4=NC=CN=C4)=O)C5CCCCC5)=O)C(C)(C)C
MDL Number:
MFCD11616089
Purity :
97%
Available in stock:
10.306 g

More details are to be found here