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JNJ-26483327
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Properties | CAS |
807640-87-5 |
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2 Registered suppliers
Molecular Formula: C22H25BrN4O2 Molecular Weight: 457.3635
Description : JNJ-26483327 is an orally bioavailable, small-molecule, multitargeted reversible tyrosine kinase inhibitor with potential antineoplastic activity. Multitargeted tyrosine kinase inhibitor JNJ-26483327 binds to and inhibits several members of the epidermal growth factor receptor (EGFR) family, including EGFR, HER2 and HER4; Src family kinases (Lyn, Yes, Fyn, Lck and Src); and vascular endothelial growth factor receptor type 3 (VEGFR3). By inhibiting several different signaling molecules that play crucial roles at various stages in tumorigenesis, this agent may inhibit tumor growth, invasion, migration and metastasis. In addition, JNJ-26483327 crosses the blood-brain barrier (BBB). - Molecular Weight :457.372
Molecular Formula : C22H25BrN4O2 Canonical SMILES : CN1CCCCCOC2=C(C=C3C(=C2)C(=NC=N3)NC4=C(C1)C=CC(=C4)Br)OC InChI : InChI=1S/C22H25BrN4O2/c1-27-8-4-3-5-9-29-21-11-17-19(12-20(21)28-2)24-14-25-22(17)26-18-10-16(23)7-6-15(18)13-27/h6-7,10-12,14H,3-5,8-9,13H2,1-2H3,(H,24,25,26) InChIKey : JXDYOSVKVSQGJM-UHFFFAOYSA-N Appearance : white solid powder Synonyms : JNJ-26483327; JNJ 26483327; JNJ26483327.
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Last update 2024-05-07
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