BGC > Product Search > Topotecan hydrochloride

Molecular Formula: C23H23N3O5.HCl;C23H24ClN3O5
Molecular Weight: 457,91

Molecular Formula: C23H23N3O5.HCl;C23H24ClN3O5
Molecular Weight: 457,91

Description :
Topocecan is a semisynthetic derivative of camptothecin with antineoplastic activity. During the S phase of the cell cycle, topotecan selectively stabilizes topoisomerase I-DNA covalent complexes, inhibiting religation of topoisomerase I-mediated single-strand DNA breaks and producing potentially lethal double-strand DNA breaks when complexes are encountered by the DNA replication machinery. Camptothecin is a cytotoxic quinoline-based alkaloid extracted from the Asian tree Camptotheca acuminata.

• Molecular Weight :457.91
• Melting Point :215°C (dec.)
• Purity :> 98%

Molecular Formula :
C23H24ClN3O5
Canonical SMILES :
CCC1(C2=C(COC1=O)C(=O)N3CC4=C(C3=C2)N=C5C=CC(=C(C5=C4)CN(C)C)O)O.Cl
InChI :
InChI=1S/C23H23N3O5.ClH/c1-4-23(30)16-8-18-20-12(9-26(18)21(28)15(16)11-31-22(23)29)7-13-14(10-25(2)3)19(27)6-5-17(13)24-20;/h5-8,27,30H,4,9-11H2,1-3H3;1H/t23-;/m0./s1
InChIKey :
DGHHQBMTXTWTJV-BQAIUKQQSA-N
Solubility :
Soluble in DMSO (Slightly, Sonicated), Methanol (Slightly, Heated), Water (Slightly, Heated)
Appearance :
Light Yellow to Dark Green Solid
Application :
Topoisomerase I Inhibitors
Storage : Store at 2-8°C
Synonyms :
1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-, hydrochloride (1:1), (4S)-; 1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-, monohydrochloride, (4S)-; 1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-, monohydrochloride, (S)-; (S)-10-[(Dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[l,2-b]quinoline-3,14(4H,12H)-dione monohydrochloride; Hycamtin; Nogitecan hydrochloride; NSC 609669; SKF 104864A; SKFS 104864A; Topotecan chlorohydrate; Xinze

More details are to be found here

Description :
Topocecan is a semisynthetic derivative of camptothecin with antineoplastic activity. During the S phase of the cell cycle, topotecan selectively stabilizes topoisomerase I-DNA covalent complexes, inhibiting religation of topoisomerase I-mediated single-strand DNA breaks and producing potentially lethal double-strand DNA breaks when complexes are encountered by the DNA replication machinery. Camptothecin is a cytotoxic quinoline-based alkaloid extracted from the Asian tree Camptotheca acuminata.

• Molecular Weight :457.91
• Melting Point :215°C (dec.)
• Purity :> 98%

Molecular Formula :
C23H24ClN3O5
Canonical SMILES :
CCC1(C2=C(COC1=O)C(=O)N3CC4=C(C3=C2)N=C5C=CC(=C(C5=C4)CN(C)C)O)O.Cl
InChI :
InChI=1S/C23H23N3O5.ClH/c1-4-23(30)16-8-18-20-12(9-26(18)21(28)15(16)11-31-22(23)29)7-13-14(10-25(2)3)19(27)6-5-17(13)24-20;/h5-8,27,30H,4,9-11H2,1-3H3;1H/t23-;/m0./s1
InChIKey :
DGHHQBMTXTWTJV-BQAIUKQQSA-N
Solubility :
Soluble in DMSO (Slightly, Sonicated), Methanol (Slightly, Heated), Water (Slightly, Heated)
Appearance :
Light Yellow to Dark Green Solid
Application :
Topoisomerase I Inhibitors
Storage : Store at 2-8°C
Synonyms :
1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-, hydrochloride (1:1), (4S)-; 1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-, monohydrochloride, (4S)-; 1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-, monohydrochloride, (S)-; (S)-10-[(Dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[l,2-b]quinoline-3,14(4H,12H)-dione monohydrochloride; Hycamtin; Nogitecan hydrochloride; NSC 609669; SKF 104864A; SKFS 104864A; Topotecan chlorohydrate; Xinze

More details are to be found here

Purity : 98%
Smile code : O=C1[C@](O)(CC)C2=C(CO1)C(N3CC4=CC5=C(CN(C)C)C(O)=CC=C5N=C4C3=C2)=O.[H]Cl
MDL Number : MFCD00866235
MolFormula : C23H24ClN3O5
MolWeight : 457.9068
Available in stock : 67.808

More details are to be found here

Purity : 98%
Smile code : O=C1[C@](O)(CC)C2=C(CO1)C(N3CC4=CC5=C(CN(C)C)C(O)=CC=C5N=C4C3=C2)=O.[H]Cl
MDL Number : MFCD00866235
MolFormula : C23H24ClN3O5
MolWeight : 457.9068
Available in stock : 67.808

More details are to be found here

Purity : 98%
Smile code : O=C1[C@](O)(CC)C2=C(CO1)C(N3CC4=CC5=C(CN(C)C)C(O)=CC=C5N=C4C3=C2)=O.[H]Cl
MDL Number : MFCD00866235
MolFormula : C23H24ClN3O5
MolWeight : 457.9068
Available in stock : 67.808

More details are to be found here

Purity : 98%
Smile code : O=C1[C@](O)(CC)C2=C(CO1)C(N3CC4=CC5=C(CN(C)C)C(O)=CC=C5N=C4C3=C2)=O.[H]Cl
MDL Number : MFCD00866235
MolFormula : C23H24ClN3O5
MolWeight : 457.9068
Available in stock : 67.808

More details are to be found here

Purity : 98%
Smile code : O=C1[C@](O)(CC)C2=C(CO1)C(N3CC4=CC5=C(CN(C)C)C(O)=CC=C5N=C4C3=C2)=O.[H]Cl
MDL Number : MFCD00866235
MolFormula : C23H24ClN3O5
MolWeight : 457.9068
Available in stock : 67.808

More details are to be found here

Purity : 98%
Smile code : O=C1[C@](O)(CC)C2=C(CO1)C(N3CC4=CC5=C(CN(C)C)C(O)=CC=C5N=C4C3=C2)=O.[H]Cl
MDL Number : MFCD00866235
MolFormula : C23H24ClN3O5
MolWeight : 457.9068
Available in stock : 67.808

More details are to be found here