BGC > Product Search > (3S)-N-[3-Hydroxy-5-[(1,4,5,6-tetrahydro-5-hydroxy-2-pyrimidinyl)amino] benzoyl]glycyl-3-(3-bromo-5-tert-butylphenyl)-beta-alanine | 1564286-55-0

Molecular Formula: C26H32BrN5O6
Molecular Weight: 590.46618

Molecular Formula: C26H32BrN5O6
Molecular Weight: 590.46618

Description :
CWHM 12 demonstrated high potency against all of the five possible β subunit binding partners (αvβ1, αvβ3, αvβ5, αvβ6 and αvβ8) in in vitro ligand-binding assays, with somewhat less potency against αvβ5 than against the other αv integrins. Treated mice with CCl4 for 3 weeks to establish fibrotic disease and then treated with CWHM 12 or vehicle for the final 3 weeks of CCl4. CWHM12 significantly reduced liver fibrosis even after fibrotic disease had been established. Similar to our findings in the liver, administration of CWHM 12 significantly inhibited progression of pulmonary fibrosis.

• Molecular Weight :590.47
• Purity :> 98%

Molecular Formula :
C26H32BrN5O6
Canonical SMILES :
CC(C)(C)C1=CC(=CC(=C1)C(CC(=O)O)NC(=O)CNC(=O)C2=CC(=CC(=C2)O)NC3=NCC(CN3)O)Br
InChI :
InChI=1S/C26H32BrN5O6/c1-26(2,3)16-4-14(5-17(27)8-16)21(10-23(36)37)32-22(35)13-28-24(38)15-6-18(9-19(33)7-15)31-25-29-11-20(34)12-30-25/h4-9,20-21,33-34H,10-13H2,1-3H3,(H,28,38)(H,32,35)(H,36,37)(H2,29,30,31)/t21-/m0/s1
InChIKey :
YDHAGPCZRFQPOI-NRFANRHFSA-N
Synonyms :
CWHM12; CWHM 12; CWHM-12.

More details are to be found here