BGC > Product Search > UNC-2025 | 1429881-91-3

Molecular Formula: C28H40N6O
Molecular Weight: 476.67

Molecular Formula: C28H40N6O
Molecular Weight: 476.67

Description :
UNC-2025 is a novel potent and highly orally bioavailable Mer/FLT3 dual inhibitor, capable of inhibiting Mer phosphorylation in vivo, following oral dosing as demonstrated by pharmaco-dynamic (PD) studies examining phospho-Mer in leukemic blasts from mouse bone marrow. Kinome profiling versus more than 300 kinases in vitro and cellular selectivity assessments demonstrate that UNC-2025 has similar subnanomolar activity against Flt3, an additional important target in acute myelogenous leukemia (AML), with pharmacologically useful selectivity versus other kinases examined.

• Molecular Weight :476.66
• Boiling Point :677.5±65.0°C at 760 mmHg
• Purity :≥95%

Molecular Formula :
C28H40N6O
Canonical SMILES :
OC1CCC(N2C=C(C=3C=CC(=CC3)CN4CCN(C)CC4)C=5C=NC(=NC52)NCCCC)CC1
InChI :
InChI=1S/C28H40N6O/c1-3-4-13-29-28-30-18-25-26(20-34(27(25)31-28)23-9-11-24(35)12-10-23)22-7-5-21(6-8-22)19-33-16-14-32(2)15-17-33/h5-8,18,20,23-24,35H,3-4,9-17,19H2,1-2H3,(H,29,30,31)/t23-,24-
InChIKey :
MJSHVHLADKXCML-RQNOJGIXNA-N
Solubility :
Soluble in DMSO, Ethanol, Water
Appearance :
White Solid
Storage : Store at -20°C
Synonyms :
Cyclohexanol, 4-[2-(butylamino)-5-[4-[(4-methyl-1-piperazinyl)methyl]phenyl]-7H-pyrrolo[2,3-d]pyrimidin-7-yl]-, trans-; trans-4-[2-(Butylamino)-5-[4-[(4-methyl-1-piperazinyl)methyl]phenyl]-7H-pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexanol; MRX 6313; UNC 2025; UNC2025

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