Suppliers for CAS
1403254-99-8
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Properties | CAS |
1403254-99-8 | Formula |
C34H44N4O4 |
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7 Registered suppliers
Amadis Chemical Company Limited
P.R.China
More details are to be found here
Dayang Chem (Hangzhou) Co.,Ltd.
P.R.China
More details are to be found here
Leap Chem Co., Ltd
P.R.China
Molecular Formula: C34H44N4O4 Molecular Weight: 572.73756
Aea.ltd
P.R.China
Molecular Formula: C34H44N4O4 Molecular Weight: 572.73756
Finetech Industry Limited
P.R.China
More details are to be found here
BOC Sciences
USA
Description : EPZ-6438 is a potent, selective, and orally bioavailable small-molecule inhibitor of EZH2 enzymatic activity. EPZ-6438 induces apoptosis and differentiation specifically in SMARCB1-deleted MRT cells. Treatment of xenograft-bearing mice with EPZ-6438 leads to dose-dependent regression of MRTs with correlative diminution of intratumoral trimethylation levels of lysine 27 on histone H3, and prevention of tumor regrowth after dosing cessation. These data demonstrate the dependency of SMARCB1 mutant MRTs on EZH2 enzymatic activity and portend the utility of EZH2-targeted drugs for the treatment of these genetically defined cancers. EPZ-6438 is currently in clinical trials. - Molecular Weight :572.75
- Purity :98%
Molecular Formula : C34H44N4O4 Canonical SMILES : CCN(C1CCOCC1)C2=CC(=CC(=C2C)C(=O)NCC3=C(C=C(NC3=O)C)C)C4=CC=C(C=C4)CN5CCOCC5 InChI : InChI=1S/C34H44N4O4/c1-5-38(29-10-14-41-15-11-29)32-20-28(27-8-6-26(7-9-27)22-37-12-16-42-17-13-37)19-30(25(32)4)33(39)35-21-31-23(2)18-24(3)36-34(31)40/h6-9,18-20,29H,5,10-17,21-22H2,1-4H3,(H,35,39)(H,36,40) InChIKey : NSQSAUGJQHDYNO-UHFFFAOYSA-N Appearance : white solid powder Synonyms : EPZ-6438; EPZ 6438; EPZ6438; E7438; E-7438; E 7438; Tazemetostat
More details are to be found here
Chemtour Biotech Co., Ltd
P.R.China
Description : EPZ-6438 is a potent, selective, and orally bioavailable small-molecule inhibitor of EZH2 enzymatic activity. EPZ-6438 induces apoptosis and differentiation specifically in SMARCB1-deleted MRT cells. Treatment of xenograft-bearing mice with EPZ-6438 leads to dose-dependent regression of MRTs with correlative diminution of intratumoral trimethylation levels of lysine 27 on histone H3, and prevention of tumor regrowth after dosing cessation. These data demonstrate the dependency of SMARCB1 mutant MRTs on EZH2 enzymatic activity and portend the utility of EZH2-targeted drugs for the treatment of these genetically defined cancers. EPZ-6438 is currently in clinical trials. - Molecular Weight :572.75
- Purity :98%
Molecular Formula : C34H44N4O4 Canonical SMILES : CCN(C1CCOCC1)C2=CC(=CC(=C2C)C(=O)NCC3=C(C=C(NC3=O)C)C)C4=CC=C(C=C4)CN5CCOCC5 InChI : InChI=1S/C34H44N4O4/c1-5-38(29-10-14-41-15-11-29)32-20-28(27-8-6-26(7-9-27)22-37-12-16-42-17-13-37)19-30(25(32)4)33(39)35-21-31-23(2)18-24(3)36-34(31)40/h6-9,18-20,29H,5,10-17,21-22H2,1-4H3,(H,35,39)(H,36,40) InChIKey : NSQSAUGJQHDYNO-UHFFFAOYSA-N Appearance : white solid powder Synonyms : EPZ-6438; EPZ 6438; EPZ6438; E7438; E-7438; E 7438; Tazemetostat
More details are to be found here
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