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Suppliers for CAS
1000669-72-6
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Properties | | CAS |
1000669-72-6 | | Formula |
C20H20N4O |
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7 Registered suppliers
Amadis Chemical Company Limited
P.R.China
More details are to be found here
Dayang Chem (Hangzhou) Co.,Ltd.
P.R.China
More details are to be found here
Leap Chem Co., Ltd
P.R.China
Molecular Formula: C20H20N4O
Molecular Weight: 332.41
Aea.ltd
P.R.China
Molecular Formula: C20H20N4O
Molecular Weight: 332.41
BOC Sciences
USA
Description : KW-2449 is a novel multikinase inhibitor, which suppresses the growth of leukemia cells with FLT3 mutations or T315I-mutated BCR/ABL translocation. Recent research showed that HDACIs increase KW-2449 lethality in Bcr/Abl(+) cells in association with inhibition of Bcr/Abl, generation of ROS, and induction of DNA damage. This strategy preferentially targets primary Bcr/Abl(+) hematopoietic cells and exhibits enhanced in vivo activity. Combining KW-2449 with HDACIs warrants attention in IM-resistant Bcr/Abl(+) leukemias. - Molecular Weight :332.407
Molecular Formula : C20H20N4O Canonical SMILES : C1CN(CCN1)C(=O)C2=CC=C(C=C2)C=CC3=NNC4=CC=CC=C43 InChI : InChI=1S/C20H20N4O/c25-20(24-13-11-21-12-14-24)16-8-5-15(6-9-16)7-10-19-17-3-1-2-4-18(17)22-23-19/h1-10,21H,11-14H2,(H,22,23)/b10-7+
InChIKey :
YYLKKYCXAOBSRM-JXMROGBWSA-N
Synonyms :
KW2449; KW-2449; KW 2449.
More details are to be found here
Chemos GmbH & Co. KG
Germany
Description : KW-2449 is a novel multikinase inhibitor, which suppresses the growth of leukemia cells with FLT3 mutations or T315I-mutated BCR/ABL translocation. Recent research showed that HDACIs increase KW-2449 lethality in Bcr/Abl(+) cells in association with inhibition of Bcr/Abl, generation of ROS, and induction of DNA damage. This strategy preferentially targets primary Bcr/Abl(+) hematopoietic cells and exhibits enhanced in vivo activity. Combining KW-2449 with HDACIs warrants attention in IM-resistant Bcr/Abl(+) leukemias. - Molecular Weight :332.407
Molecular Formula : C20H20N4O Canonical SMILES : C1CN(CCN1)C(=O)C2=CC=C(C=C2)C=CC3=NNC4=CC=CC=C43 InChI : InChI=1S/C20H20N4O/c25-20(24-13-11-21-12-14-24)16-8-5-15(6-9-16)7-10-19-17-3-1-2-4-18(17)22-23-19/h1-10,21H,11-14H2,(H,22,23)/b10-7+
InChIKey :
YYLKKYCXAOBSRM-JXMROGBWSA-N
Synonyms :
KW2449; KW-2449; KW 2449.
More details are to be found here
Santa Cruz Biotechnology, Inc.
USA
Description : KW-2449 is a novel multikinase inhibitor, which suppresses the growth of leukemia cells with FLT3 mutations or T315I-mutated BCR/ABL translocation. Recent research showed that HDACIs increase KW-2449 lethality in Bcr/Abl(+) cells in association with inhibition of Bcr/Abl, generation of ROS, and induction of DNA damage. This strategy preferentially targets primary Bcr/Abl(+) hematopoietic cells and exhibits enhanced in vivo activity. Combining KW-2449 with HDACIs warrants attention in IM-resistant Bcr/Abl(+) leukemias. - Molecular Weight :332.407
Molecular Formula : C20H20N4O Canonical SMILES : C1CN(CCN1)C(=O)C2=CC=C(C=C2)C=CC3=NNC4=CC=CC=C43 InChI : InChI=1S/C20H20N4O/c25-20(24-13-11-21-12-14-24)16-8-5-15(6-9-16)7-10-19-17-3-1-2-4-18(17)22-23-19/h1-10,21H,11-14H2,(H,22,23)/b10-7+
InChIKey :
YYLKKYCXAOBSRM-JXMROGBWSA-N
Synonyms :
KW2449; KW-2449; KW 2449.
More details are to be found here
Detailed information on the suppliers of
KW-2449 |
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