BGC > Product Search > Nintedanib (intedanib)

Description :
Nintedanib is a potent triple angiokinase inhibitor for VEGFR1/2/3, FGFR1/2/3 and PDGFRα/β with IC50 of 34 nM/13 nM/13 nM, 69 nM/37 nM/108 nM and 59 nM/65 nM. It is used for the treatment of pulmonary fibrosis, systemic sclerosis-associated interstitial lung disease, and non-small cell lung cancer (NSCLC).

• Molecular Weight :539.62
• Melting Point :> 237°C (dec.)
• Purity :≥98%

Molecular Formula :
C31H33N5O4
Canonical SMILES :
CN1CCN(CC1)CC(=O)N(C)C2=CC=C(C=C2)N=C(C3=CC=CC=C3)C4=C(NC5=C4C=CC(=C5)C(=O)OC)O
InChI :
InChI=1S/C31H33N5O4/c1-34-15-17-36(18-16-34)20-27(37)35(2)24-12-10-23(11-13-24)32-29(21-7-5-4-6-8-21)28-25-14-9-22(31(39)40-3)19-26(25)33-30(28)38/h4-14,19,33,38H,15-18,20H2,1-3H3
InChIKey :
CPMDPSXJELVGJG-UHFFFAOYSA-N
Solubility :
Soluble to 9.66 mg/L in water.
Appearance :
Light Green to Light Yellow Solid
Synonyms :
Vargatef; BIBF-1120; BIBF 1120; BIBF1120; Intedanib

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