BGC > Product Search > Treosulfan | 299-75-2

Molecular Formula: C6H14O8S2
Molecular Weight: 278.301
UN Number: 2811
PackingGroup: III

Molecular Formula: C6H14O8S2
Molecular Weight: 278.301
UN Number: 2811
PackingGroup: III

Description :
Treosulfan is the prodrug of a bifunctional sulfonate alkylating agent with myeloablative, immunosuppresive, and antineoplastic activities. Under physiological conditions, treosulfan converts nonenzymatically to L-diepoxybutane via a monoepoxide intermediate. The monoepoxide intermediate and L-diepoxybutane alkylate DNA at guanine residues and produce DNA interstrand crosslinks, resulting in DNA fragmentation and apoptosis. In escalated doses, this agent also exhbits myeloablative and immunosuppressive activities.

• Molecular Weight :278.29

Molecular Formula :
C6H14O8S2
Canonical SMILES :
CS(=O)(=O)OCC(C(COS(=O)(=O)C)O)O
InChI :
InChI=1S/C6H14O8S2/c1-15(9,10)13-3-5(7)6(8)4-14-16(2,11)12/h5-8H,3-4H2,1-2H3/t5-,6-/m0/s1
InChIKey :
YCPOZVAOBBQLRI-WDSKDSINSA-N
Synonyms :
NSC 39069; NSC39069; NSC-39069; Treosulfan; (2S,3S)-2,3-Dihydroxybutane-1,4-diyl dimethanesulfonate.

More details are to be found here

Description :
Treosulfan is the prodrug of a bifunctional sulfonate alkylating agent with myeloablative, immunosuppresive, and antineoplastic activities. Under physiological conditions, treosulfan converts nonenzymatically to L-diepoxybutane via a monoepoxide intermediate. The monoepoxide intermediate and L-diepoxybutane alkylate DNA at guanine residues and produce DNA interstrand crosslinks, resulting in DNA fragmentation and apoptosis. In escalated doses, this agent also exhbits myeloablative and immunosuppressive activities.

• Molecular Weight :278.29

Molecular Formula :
C6H14O8S2
Canonical SMILES :
CS(=O)(=O)OCC(C(COS(=O)(=O)C)O)O
InChI :
InChI=1S/C6H14O8S2/c1-15(9,10)13-3-5(7)6(8)4-14-16(2,11)12/h5-8H,3-4H2,1-2H3/t5-,6-/m0/s1
InChIKey :
YCPOZVAOBBQLRI-WDSKDSINSA-N
Synonyms :
NSC 39069; NSC39069; NSC-39069; Treosulfan; (2S,3S)-2,3-Dihydroxybutane-1,4-diyl dimethanesulfonate.

More details are to be found here

Description :
Treosulfan is the prodrug of a bifunctional sulfonate alkylating agent with myeloablative, immunosuppresive, and antineoplastic activities. Under physiological conditions, treosulfan converts nonenzymatically to L-diepoxybutane via a monoepoxide intermediate. The monoepoxide intermediate and L-diepoxybutane alkylate DNA at guanine residues and produce DNA interstrand crosslinks, resulting in DNA fragmentation and apoptosis. In escalated doses, this agent also exhbits myeloablative and immunosuppressive activities.

• Molecular Weight :278.29

Molecular Formula :
C6H14O8S2
Canonical SMILES :
CS(=O)(=O)OCC(C(COS(=O)(=O)C)O)O
InChI :
InChI=1S/C6H14O8S2/c1-15(9,10)13-3-5(7)6(8)4-14-16(2,11)12/h5-8H,3-4H2,1-2H3/t5-,6-/m0/s1
InChIKey :
YCPOZVAOBBQLRI-WDSKDSINSA-N
Synonyms :
NSC 39069; NSC39069; NSC-39069; Treosulfan; (2S,3S)-2,3-Dihydroxybutane-1,4-diyl dimethanesulfonate.

More details are to be found here