Suppliers for CAS
219580-11-7
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Properties | CAS |
219580-11-7 | Formula |
C28H41N7O3 |
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11 Registered suppliers
Dayang Chem (Hangzhou) Co.,Ltd.
P.R.China
Capot Chemical Co., Ltd.
P.R.China
More details are to be found here
Leap Chem Co., Ltd
P.R.China
Molecular Formula: C28H41N7O3 Molecular Weight: 523.678 Hazard Symbols: Xi WGKGermany: 3
Aea.ltd
P.R.China
Molecular Formula: C28H41N7O3 Molecular Weight: 523.678 Hazard Symbols: Xi WGKGermany: 3
Hangzhou Zhongqi Chem Co., Ltd
P.R.China
Molecular Formula: C28H41N7O3 Molecular Weight: 523.678 Hazard Symbols: Xi WGKGermany: 3
Finetech Industry Limited
P.R.China
More details are to be found here
Skyrun Industrial Co., Ltd.
P.R.China
More details are to be found here
BOC Sciences
USA
Description : PD173074 is a small-molecule FGFR3-selective tyrosine kinase inhibitor (TKI), as a therapeutic modality using eight UC cell lines. PD173074 suppressed cell proliferation remarkably in two cell lines, namely, UM-UC-14 and MGHU3, which expressed mutated FGFR3 protein. Cell cycle analysis revealed the growth inhibitory effect of PD173074 was associated with arrest at G(1)-S transition in a dose-depending manner. In the mouse xenograft models using subcutaneously transplanted UM-UC-14 and MGHU3, orally administered PD173074 suppressed tumor growth and induced apoptotic changes comparable with the results of our in vitro assay. These findings elucidated the effectiveness of molecular targeted approach for bladder UC harboring FGFR3 mutations and the potential utility to decrease the intravesical recurrence of nonmuscle invasive bladder UC after transurethral surgical resection. - Molecular Weight :523.682
- Purity :0.98
Molecular Formula : C28H41N7O3 Canonical SMILES : CCN(CC)CCCCNC1=NC2=NC(=C(C=C2C=N1)C3=CC(=CC(=C3)OC)OC)NC(=O)NC(C)(C)C InChI : InChI=1S/C28H41N7O3/c1-8-35(9-2)13-11-10-12-29-26-30-18-20-16-23(19-14-21(37-6)17-22(15-19)38-7)25(31-24(20)32-26)33-27(36)34-28(3,4)5/h14-18H,8-13H2,1-7H3,(H3,29,30,31,32,33,34,36) InChIKey : DXCUKNQANPLTEJ-UHFFFAOYSA-N Appearance : Yellow solid Application : Differentiation, Self-Renewal Synonyms : PD173074; PD 173074; PD-173074.
More details are to be found here
Chemos GmbH & Co. KG
Germany
Description : PD173074 is a small-molecule FGFR3-selective tyrosine kinase inhibitor (TKI), as a therapeutic modality using eight UC cell lines. PD173074 suppressed cell proliferation remarkably in two cell lines, namely, UM-UC-14 and MGHU3, which expressed mutated FGFR3 protein. Cell cycle analysis revealed the growth inhibitory effect of PD173074 was associated with arrest at G(1)-S transition in a dose-depending manner. In the mouse xenograft models using subcutaneously transplanted UM-UC-14 and MGHU3, orally administered PD173074 suppressed tumor growth and induced apoptotic changes comparable with the results of our in vitro assay. These findings elucidated the effectiveness of molecular targeted approach for bladder UC harboring FGFR3 mutations and the potential utility to decrease the intravesical recurrence of nonmuscle invasive bladder UC after transurethral surgical resection. - Molecular Weight :523.682
- Purity :0.98
Molecular Formula : C28H41N7O3 Canonical SMILES : CCN(CC)CCCCNC1=NC2=NC(=C(C=C2C=N1)C3=CC(=CC(=C3)OC)OC)NC(=O)NC(C)(C)C InChI : InChI=1S/C28H41N7O3/c1-8-35(9-2)13-11-10-12-29-26-30-18-20-16-23(19-14-21(37-6)17-22(15-19)38-7)25(31-24(20)32-26)33-27(36)34-28(3,4)5/h14-18H,8-13H2,1-7H3,(H3,29,30,31,32,33,34,36) InChIKey : DXCUKNQANPLTEJ-UHFFFAOYSA-N Appearance : Yellow solid Application : Differentiation, Self-Renewal Synonyms : PD173074; PD 173074; PD-173074.
More details are to be found here
CM Fine Chemicals
Switzerland
Description : PD173074 is a small-molecule FGFR3-selective tyrosine kinase inhibitor (TKI), as a therapeutic modality using eight UC cell lines. PD173074 suppressed cell proliferation remarkably in two cell lines, namely, UM-UC-14 and MGHU3, which expressed mutated FGFR3 protein. Cell cycle analysis revealed the growth inhibitory effect of PD173074 was associated with arrest at G(1)-S transition in a dose-depending manner. In the mouse xenograft models using subcutaneously transplanted UM-UC-14 and MGHU3, orally administered PD173074 suppressed tumor growth and induced apoptotic changes comparable with the results of our in vitro assay. These findings elucidated the effectiveness of molecular targeted approach for bladder UC harboring FGFR3 mutations and the potential utility to decrease the intravesical recurrence of nonmuscle invasive bladder UC after transurethral surgical resection. - Molecular Weight :523.682
- Purity :0.98
Molecular Formula : C28H41N7O3 Canonical SMILES : CCN(CC)CCCCNC1=NC2=NC(=C(C=C2C=N1)C3=CC(=CC(=C3)OC)OC)NC(=O)NC(C)(C)C InChI : InChI=1S/C28H41N7O3/c1-8-35(9-2)13-11-10-12-29-26-30-18-20-16-23(19-14-21(37-6)17-22(15-19)38-7)25(31-24(20)32-26)33-27(36)34-28(3,4)5/h14-18H,8-13H2,1-7H3,(H3,29,30,31,32,33,34,36) InChIKey : DXCUKNQANPLTEJ-UHFFFAOYSA-N Appearance : Yellow solid Application : Differentiation, Self-Renewal Synonyms : PD173074; PD 173074; PD-173074.
More details are to be found here
Santa Cruz Biotechnology, Inc.
USA
Description : PD173074 is a small-molecule FGFR3-selective tyrosine kinase inhibitor (TKI), as a therapeutic modality using eight UC cell lines. PD173074 suppressed cell proliferation remarkably in two cell lines, namely, UM-UC-14 and MGHU3, which expressed mutated FGFR3 protein. Cell cycle analysis revealed the growth inhibitory effect of PD173074 was associated with arrest at G(1)-S transition in a dose-depending manner. In the mouse xenograft models using subcutaneously transplanted UM-UC-14 and MGHU3, orally administered PD173074 suppressed tumor growth and induced apoptotic changes comparable with the results of our in vitro assay. These findings elucidated the effectiveness of molecular targeted approach for bladder UC harboring FGFR3 mutations and the potential utility to decrease the intravesical recurrence of nonmuscle invasive bladder UC after transurethral surgical resection. - Molecular Weight :523.682
- Purity :0.98
Molecular Formula : C28H41N7O3 Canonical SMILES : CCN(CC)CCCCNC1=NC2=NC(=C(C=C2C=N1)C3=CC(=CC(=C3)OC)OC)NC(=O)NC(C)(C)C InChI : InChI=1S/C28H41N7O3/c1-8-35(9-2)13-11-10-12-29-26-30-18-20-16-23(19-14-21(37-6)17-22(15-19)38-7)25(31-24(20)32-26)33-27(36)34-28(3,4)5/h14-18H,8-13H2,1-7H3,(H3,29,30,31,32,33,34,36) InChIKey : DXCUKNQANPLTEJ-UHFFFAOYSA-N Appearance : Yellow solid Application : Differentiation, Self-Renewal Synonyms : PD173074; PD 173074; PD-173074.
More details are to be found here
Detailed information on the suppliers of
PD 173074
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