BGC > Product Search > 4-[4-(2,4,6-Trimethylphenylamino)pyrimidin-2-ylamino]benzonitrile | 244767-67-7

Molecular Formula: C20H19N5
Molecular Weight: 329.405

Molecular Formula: C20H19N5
Molecular Weight: 329.405

Molecular Formula: C20H19N5
Molecular Weight: 329.405

Description :
Dapivirine, also known as TMC 120, TMC 120 R147681, is a NNRTI for HIV reverse transcriptase with IC50 of 24 nM, inhibiting a broad panel of HIV-1 isolates from different classes, inclucing a wide range of NNRTI-resistant isolates.

• Molecular Weight :329.407
• Boiling Point :557.9±60.0 °C at 760 mmHg
• Purity :99.90%

Molecular Formula :
C20H19N5
Canonical SMILES :
CC1=CC(=C(C(=C1)C)NC2=NC(=NC=C2)NC3=CC=C(C=C3)C#N)C
InChI :
InChI=1S/C20H19N5/c1-13-10-14(2)19(15(3)11-13)24-18-8-9-22-20(25-18)23-17-6-4-16(12-21)5-7-17/h4-11H,1-3H3,(H2,22,23,24,25)
InChIKey :
ILAYIAGXTHKHNT-UHFFFAOYSA-N
Solubility :
In Vitro: DMSO : ≥ 47 mg/mL(142.68 mM) In Vivo: 1.Add each solvent one by one:10% DMSO > > 40%PEG300 > > 5%Tween-80 > > 45% saline Solubility: 2.08 mg/mL (6.31 mM); Suspended solution; Need ultrasonic 2.Add each solvent one by one:10% DMSO > > 90%corn oil Solubility: ≥ 2.08 mg/mL (6.31 mM); Clear solution
Appearance :
White to off-white (Solid)
Storage : Powder: -20°C: 3 years 4°C: 2 years In solvent: -80°C: 6 months -20°C: 1 month
Synonyms :
TMC120; TMC 120; TMC-120; R 147681; R-147681; R147681; Dapivirine.

More details are to be found here

Description :
Dapivirine, also known as TMC 120, TMC 120 R147681, is a NNRTI for HIV reverse transcriptase with IC50 of 24 nM, inhibiting a broad panel of HIV-1 isolates from different classes, inclucing a wide range of NNRTI-resistant isolates.

• Molecular Weight :329.407
• Boiling Point :557.9±60.0 °C at 760 mmHg
• Purity :99.90%

Molecular Formula :
C20H19N5
Canonical SMILES :
CC1=CC(=C(C(=C1)C)NC2=NC(=NC=C2)NC3=CC=C(C=C3)C#N)C
InChI :
InChI=1S/C20H19N5/c1-13-10-14(2)19(15(3)11-13)24-18-8-9-22-20(25-18)23-17-6-4-16(12-21)5-7-17/h4-11H,1-3H3,(H2,22,23,24,25)
InChIKey :
ILAYIAGXTHKHNT-UHFFFAOYSA-N
Solubility :
In Vitro: DMSO : ≥ 47 mg/mL(142.68 mM) In Vivo: 1.Add each solvent one by one:10% DMSO > > 40%PEG300 > > 5%Tween-80 > > 45% saline Solubility: 2.08 mg/mL (6.31 mM); Suspended solution; Need ultrasonic 2.Add each solvent one by one:10% DMSO > > 90%corn oil Solubility: ≥ 2.08 mg/mL (6.31 mM); Clear solution
Appearance :
White to off-white (Solid)
Storage : Powder: -20°C: 3 years 4°C: 2 years In solvent: -80°C: 6 months -20°C: 1 month
Synonyms :
TMC120; TMC 120; TMC-120; R 147681; R-147681; R147681; Dapivirine.

More details are to be found here