BGC > Product Search > (3R,5S,6S,7S,8S,9S,10S,13R,14S,17R)-6-Ethyl-17-((R)-5-hydroxypentan-2-yl)-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthrene-3,7-diol | 1632118-69-4

Molecular Formula: C26H46O3
Molecular Weight: 406.64164

Molecular Formula: C26H46O3
Molecular Weight: 406.64164

Description :
BAR-501, a UDCA derivative, is a selective GPBAR1 agonist devoid of any FXR agonistic activity. BAR-501 effectively transactivates GPBAR1 in HEK293 cells overexpressing a CRE along with GPBAR1, with a EC50 of 1 μM. Besides, it protects against development of portal hypertension in rodent models of liver injury and endothelial dysfunction.

• Molecular Weight :406.651
• Boiling Point :527.6±25.0 °C | Condition: Press: 760 Torr

Molecular Formula :
C26H46O3
Canonical SMILES :
C[C@H](CCCO)[C@H]1CC[C@@]2([H])[C@]3([H])[C@@H](O)[C@@H](CC)[C@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])CC[C@]12C
InChI :
1S/C26H46O3/c1-5-18-22-15-17(28)10-12-26(22,4)21-11-13-25(3)19(16(2)7-6-14-27)8-9-20(25)23(21)24(18)29/h16-24,27-29H,5-15H2,1-4H3/t16-,17-,18+,19-,20+,21+,22+,23+,24+,25-,26-/m1/s1
InChIKey :
DQBAHTQWQZRMFH-CRPAWOMZSA-N
Solubility :
Soluble in DMSO
Appearance :
Solid powder
Storage : Store in a cool and dry place and at 0 - 4℃ for short term (days to weeks) or -42℃ for long term (months to years).
Synonyms :
3R,5S,6S,7S,8S,9S,10S,13R,14S,17R)-6-ethyl-17-((R)-5-hydroxypentan-2-yl)-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthrene-3,7-diol; BAR-501; BAR 501; BAR501

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