|
Suppliers for CAS
1611493-60-7
(2R,5S,13aR)-8-Hydroxy-7,9-dioxo-N-(2,4,6-trifluorobenzyl)-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazepine-10-carboxamide
|
Properties | | CAS |
1611493-60-7 |
|
7 Registered suppliers
Hangzhou Meite Industry Co., Ltd (Hangzhou Meite Chemical Co., Ltd)
P.R.China
Leap Chem Co., Ltd
P.R.China
Guangzhou Topwork Chemical Co., Ltd.
P.R.China
Aea.ltd
P.R.China
BOC Sciences
USA
Description : Bictegravir is a novel, potent inhibitor of HIV-1 integrase with an IC50 of 7.5 nM for strand transfer activity. Bictegravir is a drug of the integrase inhibitor class that was copied from Dolutegravir by scientists at Gilead Sciences. Bictegravir also inhibits HIV-1 viral infection in MT-2 and MT-4 cells, CD4+ T cells, and macrophages (EC50s = 1.5, 2.5, 1.5, and 6.6 nM, respectively) without exhibiting cytotoxicity (CC50s = 10.3, 3.7, 13, and 29.8 μM, respectively). In 2016, bictegravir was in a Phase 3 trial as part of a single tablet regimen in combination with tenofovir alafenamide (TAF) and emtricitabine (FTC) for the treatment of HIV-1 infection. - Molecular Weight :449.39
- Boiling Point :682.5±55.0 °C at 760 mmHg
- Purity :≥98%
Molecular Formula : C21H18F3N3O5 Canonical SMILES : C1CC2CC1N3C(O2)CN4C=C(C(=O)C(=C4C3=O)O)C(=O)NCC5=C(C=C(C=C5F)F)F
InChI :
InChI=1S/C21H18F3N3O5/c22-9-3-14(23)12(15(24)4-9)6-25-20(30)13-7-26-8-16-27(10-1-2-11(5-10)32-16)21(31)17(26)19(29)18(13)28/h3-4,7,10-11,16,29H,1-2,5-6,8H2,(H,25,30)/t10-,11+,16+/m0/s1
InChIKey :
SOLUWJRYJLAZCX-LYOVBCGYSA-N
Solubility :
Soluble in DMSO.
Appearance :
Off-white to White Solid
Storage : Powder: -20°C 3 years 4°C 2 years In solvent: -80°C 6 months -20°C 1 months
Synonyms :
GS-9883; GS 9883; GS9883
More details are to be found here
Ambeed, Inc.
USA
Purity : 98% Smile code : O=C(C1=CN(C2=C(O)C1=O)C[C@@]3([H])O[C@](C4)([H])CC[C@]4([H])N3C2=O)NCC5=C(F)C=C(F)C=C5F
MDL Number : MFCD31536971
MolFormula : C21H18F3N3O5
MolWeight : 449.3799
Available in stock : 50.606
More details are to be found here
BLD Pharmatech Ltd
P.R.China
(2R,5S,13aR)-8-Hydroxy-7,9-dioxo-N-(2,4,6-trifluorobenzyl)-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazepine-10-carboxamide
details
Smile code: O=C(C1=CN(C2=C(O)C1=O)C[C@@]3([H])O[C@](C4)([H])CC[C@]4([H])N3C2=O)NCC5=C(F)C=C(F)C=C5F
MDL Number:
MFCD31536971
Purity :
98%
Available in stock:
42.855 g
More details are to be found here
|
details