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Suppliers for CAS
1584121-99-2
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Properties | CAS |
1584121-99-2 |
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2 Registered suppliers
Leap Chem Co., Ltd
P.R.China
BOC Sciences
USA
Description : IT 901, a bioactive naphthalenethiobarbiturate derivative, potently inhibits the NF-κB subunit c-Rel with IC50 value of 3 μM. It shows its anticancer properties in Hematologic Malignancies by inhibiting the oxidative stress response in lymphoma cells. It suppressed graft-versus-host disease while preserving graft-versus-lymphoma activity during allogeneic transplantation. It did not elicit increased levels of reactive oxygen species in normal leukocytes, illustrating its cancer selective properties. It is used for the treatment of human B-cell lymphoma and reveals antitumor properties in vitro and in vivo. It is also a novel therapeutic agent to ameliorate graft-versus-host disease. - Molecular Weight :342.37
- Purity :≥98% by HPLC
Molecular Formula : C17H14N2O4S Canonical SMILES : COC1=CC(=C(C2=CC=CC=C21)C=C3C(=O)NC(=S)NC3=O)OC InChI : InChI=1S/C17H14N2O4S/c1-22-13-8-14(23-2)11(9-5-3-4-6-10(9)13)7-12-15(20)18-17(24)19-16(12)21/h3-8H,1-2H3,(H2,18,19,20,21,24) InChIKey : JHOPCCOYRKEHQU-UHFFFAOYSA-N Synonyms : IT-901; IT 901; IT901; 5-[(2,4-Dimethoxy-1-naphthalenyl)methylene]dihydro-2-thioxo-4,6(1H,5H)-pyrimidinedione
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It-901
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Last update 2024-05-03
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