BGC > Product Search > Thiazovivin | 1226056-71-8

Molecular Formula: C15H13N5OS
Molecular Weight: 311.36162
Hazard Symbols: Xn
WGKGermany: 3

Molecular Formula: C15H13N5OS
Molecular Weight: 311.36162
Hazard Symbols: Xn
WGKGermany: 3

Description :
Thiazovivin is a selective, cell permeable small molecule that directly targets Rho-associated kinase (ROCK). In addition, Thiazovivin protects human embryonic stem cells (hESCs) in the absence of ECM by regulating E-cadherin mediated cell-cell interaction. This observation suggests that Thiazovivin promotes cell survival. In other studies Thiazovivin, in combination with inhibitors of the TGF-β receptor and MEK pathway, has shown to improve reprogramming efficiency by more than 200-fold.

• Molecular Weight :311.363
• Purity :0.98

Molecular Formula :
C15H13N5OS
Canonical SMILES :
C1=CC=C(C=C1)CNC(=O)C2=CSC(=N2)NC3=NC=NC=C3
InChI :
InChI=1S/C15H13N5OS/c21-14(17-8-11-4-2-1-3-5-11)12-9-22-15(19-12)20-13-6-7-16-10-18-13/h1-7,9-10H,8H2,(H,17,21)(H,16,18,19,20)
InChIKey :
DOBKQCZBPPCLEG-UHFFFAOYSA-N
Appearance :
Light brown powder
Application :
Reprogramming, Self-Renewal
Synonyms :
Thiazovivin; 1226056-71-8; N-benzyl-2-(pyrimidin-4-ylamino)thiazole-4-carboxamide; Thiazovivin (GMP); N-benzyl-2-(pyrimidin-4-ylamino)-1,3-thiazole-4-carboxamide; N-Benzyl-2-(pyrimidin-4-ylamino)-thiazole-4-carboxamide; N-(PHENYLMETHYL)-2-(4-PYRIMIDINYLAMINO)-4-THIAZOLECARBOXAMIDE; N-Benzyl-[2-(pyrimidin-4-yl)amino]thiazole-4-carboxamide; 4-THIAZOLECARBOXAMIDE, N-(PHENYLMETHYL)-2-(4-PYRIMIDINYLAMINO)-; SR-01000650935; C15H13N5OS; MLS006011152; SCHEMBL669856; CHEMBL3184878; DTXSID00673091; HMS3654N10; AMY36698; EX-A1693; HB3240; HY-13257G; MFCD16495823; s1459; AKOS016010502; CCG-267592; CS-0468; NCGC00187983-01; NCGC00187983-10; AC-28391; AS-16722; HY-13257; SMR004702926; CS-0626100; FT-0675156; SW219580-1; A25616; EN300-1719578; J-004834; SR-01000650935-1; SR-01000650935-2; Z2044738962; N-Benzyl-[2-(pyrimidin-4-yl)amino]t hiazole-4-carboxamide; N-Benzyl-2-[(pyrimidin-4-yl)amino]-1,3-thiazole-4-carboxamide

More details are to be found here

Description :
Thiazovivin is a selective, cell permeable small molecule that directly targets Rho-associated kinase (ROCK). In addition, Thiazovivin protects human embryonic stem cells (hESCs) in the absence of ECM by regulating E-cadherin mediated cell-cell interaction. This observation suggests that Thiazovivin promotes cell survival. In other studies Thiazovivin, in combination with inhibitors of the TGF-β receptor and MEK pathway, has shown to improve reprogramming efficiency by more than 200-fold.

• Molecular Weight :311.363
• Purity :0.98

Molecular Formula :
C15H13N5OS
Canonical SMILES :
C1=CC=C(C=C1)CNC(=O)C2=CSC(=N2)NC3=NC=NC=C3
InChI :
InChI=1S/C15H13N5OS/c21-14(17-8-11-4-2-1-3-5-11)12-9-22-15(19-12)20-13-6-7-16-10-18-13/h1-7,9-10H,8H2,(H,17,21)(H,16,18,19,20)
InChIKey :
DOBKQCZBPPCLEG-UHFFFAOYSA-N
Appearance :
Light brown powder
Application :
Reprogramming, Self-Renewal
Synonyms :
Thiazovivin; 1226056-71-8; N-benzyl-2-(pyrimidin-4-ylamino)thiazole-4-carboxamide; Thiazovivin (GMP); N-benzyl-2-(pyrimidin-4-ylamino)-1,3-thiazole-4-carboxamide; N-Benzyl-2-(pyrimidin-4-ylamino)-thiazole-4-carboxamide; N-(PHENYLMETHYL)-2-(4-PYRIMIDINYLAMINO)-4-THIAZOLECARBOXAMIDE; N-Benzyl-[2-(pyrimidin-4-yl)amino]thiazole-4-carboxamide; 4-THIAZOLECARBOXAMIDE, N-(PHENYLMETHYL)-2-(4-PYRIMIDINYLAMINO)-; SR-01000650935; C15H13N5OS; MLS006011152; SCHEMBL669856; CHEMBL3184878; DTXSID00673091; HMS3654N10; AMY36698; EX-A1693; HB3240; HY-13257G; MFCD16495823; s1459; AKOS016010502; CCG-267592; CS-0468; NCGC00187983-01; NCGC00187983-10; AC-28391; AS-16722; HY-13257; SMR004702926; CS-0626100; FT-0675156; SW219580-1; A25616; EN300-1719578; J-004834; SR-01000650935-1; SR-01000650935-2; Z2044738962; N-Benzyl-[2-(pyrimidin-4-yl)amino]t hiazole-4-carboxamide; N-Benzyl-2-[(pyrimidin-4-yl)amino]-1,3-thiazole-4-carboxamide

More details are to be found here

Description :
Thiazovivin is a selective, cell permeable small molecule that directly targets Rho-associated kinase (ROCK). In addition, Thiazovivin protects human embryonic stem cells (hESCs) in the absence of ECM by regulating E-cadherin mediated cell-cell interaction. This observation suggests that Thiazovivin promotes cell survival. In other studies Thiazovivin, in combination with inhibitors of the TGF-β receptor and MEK pathway, has shown to improve reprogramming efficiency by more than 200-fold.

• Molecular Weight :311.363
• Purity :0.98

Molecular Formula :
C15H13N5OS
Canonical SMILES :
C1=CC=C(C=C1)CNC(=O)C2=CSC(=N2)NC3=NC=NC=C3
InChI :
InChI=1S/C15H13N5OS/c21-14(17-8-11-4-2-1-3-5-11)12-9-22-15(19-12)20-13-6-7-16-10-18-13/h1-7,9-10H,8H2,(H,17,21)(H,16,18,19,20)
InChIKey :
DOBKQCZBPPCLEG-UHFFFAOYSA-N
Appearance :
Light brown powder
Application :
Reprogramming, Self-Renewal
Synonyms :
Thiazovivin; 1226056-71-8; N-benzyl-2-(pyrimidin-4-ylamino)thiazole-4-carboxamide; Thiazovivin (GMP); N-benzyl-2-(pyrimidin-4-ylamino)-1,3-thiazole-4-carboxamide; N-Benzyl-2-(pyrimidin-4-ylamino)-thiazole-4-carboxamide; N-(PHENYLMETHYL)-2-(4-PYRIMIDINYLAMINO)-4-THIAZOLECARBOXAMIDE; N-Benzyl-[2-(pyrimidin-4-yl)amino]thiazole-4-carboxamide; 4-THIAZOLECARBOXAMIDE, N-(PHENYLMETHYL)-2-(4-PYRIMIDINYLAMINO)-; SR-01000650935; C15H13N5OS; MLS006011152; SCHEMBL669856; CHEMBL3184878; DTXSID00673091; HMS3654N10; AMY36698; EX-A1693; HB3240; HY-13257G; MFCD16495823; s1459; AKOS016010502; CCG-267592; CS-0468; NCGC00187983-01; NCGC00187983-10; AC-28391; AS-16722; HY-13257; SMR004702926; CS-0626100; FT-0675156; SW219580-1; A25616; EN300-1719578; J-004834; SR-01000650935-1; SR-01000650935-2; Z2044738962; N-Benzyl-[2-(pyrimidin-4-yl)amino]t hiazole-4-carboxamide; N-Benzyl-2-[(pyrimidin-4-yl)amino]-1,3-thiazole-4-carboxamide

More details are to be found here