BGC > Product Search > SB431542

Description :
SB-431542 is a potent and selective inhibitor of the TGF-β1 receptor ALK5 (IC50 = 94 nM). It is a less potent antagonist of ALK4 (IC50 = 140 nM) and ALK7. It does not affect the BMP receptors ALK2, ALK3, ALK6, or a panel of other kinases tested.

• Molecular Weight :384.39
• Purity :98%

Molecular Formula :
C22H16N4O3
Canonical SMILES :
C1OC2=C(O1)C=C(C=C2)C3=C(NC(=N3)C4=CC=C(C=C4)C(=O)N)C5=CC=CC=N5
InChI :
InChI=1S/C22H16N4O3/c23-21(27)13-4-6-14(7-5-13)22-25-19(20(26-22)16-3-1-2-10-24-16)15-8-9-17-18(11-15)29-12-28-17/h1-11H,12H2,(H2,23,27)(H,25,26)
InChIKey :
FHYUGAJXYORMHI-UHFFFAOYSA-N
Appearance :
Solid
Application :
Reprogramming, Differentiation
Synonyms :
SB431542; SB-431542; SB 431542

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