BGC > Product Search > Nemorubicin | 108852-90-0

Molecular Formula: C32H37NO13
Molecular Weight: 643.638

Molecular Formula: C32H37NO13
Molecular Weight: 643.638

Molecular Formula: C32H37NO13
Molecular Weight: 643.638

Description :
Nemorubicin, is a doxorubicin derivative that differs significantly from its parent drug in terms of spectrum of antitumor activity, metabolism and toxicity profile. The drug is active on tumors resistant to alkylating agents, topoisomerase II inhibitors and platinum derivatives.

• Molecular Weight :643.23
• Boiling Point :852.2±65.0°C (Predicted)
• Purity :≥97% by HPLC

Molecular Formula :
C32H37NO13
Canonical SMILES :
CC1C(C(CC(O1)OC2CC(CC3=C(C4=C(C(=C23)O)C(=O)C5=C(C4=O)C=CC=C5OC)O)(C(=O)CO)O)N6CCOC(C6)OC)O
InChI :
InChI=1S/C32H37NO13/c1-14-27(36)17(33-7-8-44-22(12-33)43-3)9-21(45-14)46-19-11-32(41,20(35)13-34)10-16-24(19)31(40)26-25(29(16)38)28(37)15-5-4-6-18(42-2)23(15)30(26)39/h4-6,14,17,19,21-22,27,34,36,38,40-41H,7-13H2,1-3H3/t14-,17-,19-,21-,22-,27+,32-/m0/s1
InChIKey :
CTMCWCONSULRHO-UHQPFXKFSA-N
Solubility :
Soluble in DMSO; Insoluble in Water
Appearance :
Red to Pink Solid Powder
Application :
ADCs Cytotoxin
Storage : Store at 2-8°C for short term (days to weeks) or -20°C for long term (months to years)
Synonyms :
Methoxymorpholinyldoxorubicin; PNU152243A; PNU-152243A; PNU 152243A; (1S,3S)-3,5,12-trihydroxy-3-(hydroxyacetyl)-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 2,3,6-trideoxy-3-[(2S)-2-methoxymorpholin-4-yl]-α-L-lyxo-hexopyranoside; 5,12-Naphthacenedione, 7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-10-[[2,3,6-trideoxy-3-[(2S)-2-methoxy-4-morpholinyl]-α-L-lyxo-hexopyranosyl]oxy]-, (8S,10S)-; 3'-Deamino-3'-(2(S)-methoxy-4-morpholinyl)doxorubicin; Methoxymorpholino-doxorubicin

More details are to be found here

Description :
Nemorubicin, is a doxorubicin derivative that differs significantly from its parent drug in terms of spectrum of antitumor activity, metabolism and toxicity profile. The drug is active on tumors resistant to alkylating agents, topoisomerase II inhibitors and platinum derivatives.

• Molecular Weight :643.23
• Boiling Point :852.2±65.0°C (Predicted)
• Purity :≥97% by HPLC

Molecular Formula :
C32H37NO13
Canonical SMILES :
CC1C(C(CC(O1)OC2CC(CC3=C(C4=C(C(=C23)O)C(=O)C5=C(C4=O)C=CC=C5OC)O)(C(=O)CO)O)N6CCOC(C6)OC)O
InChI :
InChI=1S/C32H37NO13/c1-14-27(36)17(33-7-8-44-22(12-33)43-3)9-21(45-14)46-19-11-32(41,20(35)13-34)10-16-24(19)31(40)26-25(29(16)38)28(37)15-5-4-6-18(42-2)23(15)30(26)39/h4-6,14,17,19,21-22,27,34,36,38,40-41H,7-13H2,1-3H3/t14-,17-,19-,21-,22-,27+,32-/m0/s1
InChIKey :
CTMCWCONSULRHO-UHQPFXKFSA-N
Solubility :
Soluble in DMSO; Insoluble in Water
Appearance :
Red to Pink Solid Powder
Application :
ADCs Cytotoxin
Storage : Store at 2-8°C for short term (days to weeks) or -20°C for long term (months to years)
Synonyms :
Methoxymorpholinyldoxorubicin; PNU152243A; PNU-152243A; PNU 152243A; (1S,3S)-3,5,12-trihydroxy-3-(hydroxyacetyl)-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 2,3,6-trideoxy-3-[(2S)-2-methoxymorpholin-4-yl]-α-L-lyxo-hexopyranoside; 5,12-Naphthacenedione, 7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-10-[[2,3,6-trideoxy-3-[(2S)-2-methoxy-4-morpholinyl]-α-L-lyxo-hexopyranosyl]oxy]-, (8S,10S)-; 3'-Deamino-3'-(2(S)-methoxy-4-morpholinyl)doxorubicin; Methoxymorpholino-doxorubicin

More details are to be found here