BGC > Product Search > GLPG0187 | 1320346-97-1

Molecular Formula: C29H37N7O5S
Molecular Weight: 595.71298

Molecular Formula: C29H37N7O5S
Molecular Weight: 595.71298

Description :
GLPG-0187 is a small molecule integrin receptor antagonist (IRA) with nanomolar affinity for the RGD-integrin receptors αvβ1, αvβ3, αvβ5, αvβ6 and α5β1 (IC50s = 1.2-3.7 nM). Integrin receptors are expressed on the surface of tumor vessel endothelial cells and some types of cancer cells, and play a crucial role in endothelial cell adhesion and migration. This compound shows an inhibitory activity of angiogenesis, bone-resorption and tumor, which is hopefully used as an anticancer drug.

• Molecular Weight :595.719
• Purity :≥98 %

Molecular Formula :
C29H37N7O5S
Canonical SMILES :
CC1=C(N=C(N=C1NCC(C(=O)O)NS(=O)(=O)C2=CC=C(C=C2)OC)C)N3CCC(CC3)C4=NC5=C(CCCN5)C=C4
InChI :
InChI=1S/C29H37N7O5S/c1-18-26(31-17-25(29(37)38)35-42(39,40)23-9-7-22(41-3)8-10-23)32-19(2)33-28(18)36-15-12-20(13-16-36)24-11-6-21-5-4-14-30-27(21)34-24/h6-11,20,25,35H,4-5,12-17H2,1-3H3,(H,30,34)(H,37,38)(H,31,32,33)/t25-/m0/s1
InChIKey :
CXHCNOMGODVIKB-VWLOTQADSA-N
Solubility :
Soluble in DMSO.
Appearance :
Solid Powder
Application :
An integrin receptor antagonist (IRA) can be used as an anticancer drug.
Storage : Store in a cool and dry place and at 0-4 ℃ for short term (days to weeks) or -66 ℃ for long term (months to years).
Synonyms :
GLPG0187; GLPG 0187; GLPG-0187; UNII-43A5P87Z4T; 43A5P87Z4T; SCHEMBL2372722; CHEMBL3319236; (2S)-3-[[2,5-dimethyl-6-[4-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)piperidin-1-yl]pyrimidin-4-yl]amino]-2-[(4-methoxyphenyl)sulfonylamino]propanoic acid

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