|
|
BGC > Product Search > L-Phenylalanine, 4-[bis(2-chloroethyl)oxidoamino]-, (hydrochloride) (1:2) | 685898-44-6
Suppliers for CAS
685898-44-6
|
Properties | CAS |
685898-44-6 | Formula |
C13H20Cl4N2O3 |
|
|
2 Registered suppliers
Leap Chem Co., Ltd
P.R.China
Molecular Formula: C13H20Cl4N2O3 Molecular Weight: 394.13
BOC Sciences
USA
Description : PX-478 is an HIF-1alpha inhibitor and an orally active small molecule with potential antineoplastic activity. Although its mechanism of action has yet to be fully elucidated, HIF1-alpha inhibitor PX-478 appears to inhibit hypoxia-inducible factor 1-alpha (HIF1A) expression, which may result in decreased expression of HIF1A downstream target genes important to tumor growth and survival, a reduction in tumor cell proliferation, and the induction of tumor cell apoptosis. The inhibitory effect of this agent is independent of the tumor suppressor genes VHL and p53 and may be related to derangements in glucose uptake and metabolism due to inhibition of glucose transporter-1 (Glut-1). PX-478 has excellent activity against established human tumor xenografts, providing tumor regressions with prolonged growth delays which correlate positively with HIF-1 levels. PX-478 is a highly water soluble molecule, with good i.v., i.p. and p.o. antitumor activity. It is rapidly absorbed following oral and i.p. administration and gives excellent Cmax and AUC via these routes. - Molecular Weight :394.1
- Purity :> 98%
Molecular Formula : C13H18Cl2N2O3.2HCl Canonical SMILES : C1=CC(=CC=C1CC(C(=O)O)N)[N+](CCCl)(CCCl)[O-].Cl.Cl InChI : InChI=1S/C13H18Cl2N2O3.2ClH/c14-5-7-17(20,8-6-15)11-3-1-10(2-4-11)9-12(16)13(18)19;;/h1-4,12H,5-9,16H2,(H,18,19);2*1H/t12-;;/m0../s1 InChIKey : GIGCDIVNDFQKRA-LTCKWSDVSA-N Appearance : White to Off-white Solid Synonyms : PX-478 2HCl; PX-478 hydrochloride; Melphalan N-Oxide Impurity HCl; Melphalan N-Oxide Impurity hydrochloride; L-Phenylalanine, 4-[bis(2-chloroethyl)oxidoamino]-, dihydrochloride; L-Phenylalanine, 4-[bis(2-chloroethyl)oxidoamino]-, hydrochloride (1:2)
More details are to be found here
|
|
|
Privileged suppliers
Last update 2024-06-11
|