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Suppliers for
di-tert-Butyl dicarbonate (Di-BOC) (BOC-2O)
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Properties | CAS |
24424-99-5 | Formula |
C10H18O5 | EINECS |
246-240-1 |
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6 Registered suppliers
Di-tert-butyl dicarbonate is a reagent widely used in organic synthesis. This carbonate ester reacts with amines to give N-tert-butoxycarbonyl or so-called Boc derivatives. These derivatives do not behave as amines, which allows certain subsequent transformations to occur that would have otherwise affected the amine functional group. The Boc can later be removed from the amine using acids. Thus, Boc serves as a protective group, for instance in solid phase peptide synthesis. It is unreactive to most bases and nucleophiles, allowing for an orthogonal Fluorenylmethyloxycarbonyl chloride (FMOC-Cl) protection.
| Appearance & Physical State | White to off-white microcrystalline powder
| Density | 0.95 g/mL at 25 °C(lit.)
| Melting Point | 23 °C(lit.)
| Boiling Point | 65-67 °C
| Flash Point | 99 °F
| Refractive Index | n20/D 1.409(lit.)
| Storage Condition | 2-8°C |
Di-tert-butyl dicarbonate is a reagent widely used in organic synthesis. This carbonate ester reacts with amines to give N-tert-butoxycarbonyl or so-called Boc derivatives. These derivatives do not behave as amines, which allows certain subsequent transformations to occur that would have otherwise affected the amine functional group. The Boc can later be removed from the amine using acids. Thus, Boc serves as a protective group, for instance in solid phase peptide synthesis. It is unreactive to most bases and nucleophiles, allowing for an orthogonal Fluorenylmethyloxycarbonyl chloride (FMOC-Cl) protection.
| Appearance & Physical State | White to off-white microcrystalline powder
| Density | 0.95 g/mL at 25 °C(lit.)
| Melting Point | 23 °C(lit.)
| Boiling Point | 65-67 °C
| Flash Point | 99 °F
| Refractive Index | n20/D 1.409(lit.)
| Storage Condition | 2-8°C |
Di-tert-butyl dicarbonate is a reagent widely used in organic synthesis. This carbonate ester reacts with amines to give N-tert-butoxycarbonyl or so-called Boc derivatives. These derivatives do not behave as amines, which allows certain subsequent transformations to occur that would have otherwise affected the amine functional group. The Boc can later be removed from the amine using acids. Thus, Boc serves as a protective group, for instance in solid phase peptide synthesis. It is unreactive to most bases and nucleophiles, allowing for an orthogonal Fluorenylmethyloxycarbonyl chloride (FMOC-Cl) protection.
| Appearance & Physical State | White to off-white microcrystalline powder
| Density | 0.95 g/mL at 25 °C(lit.)
| Melting Point | 23 °C(lit.)
| Boiling Point | 65-67 °C
| Flash Point | 99 °F
| Refractive Index | n20/D 1.409(lit.)
| Storage Condition | 2-8°C |
Di-tert-butyl dicarbonate is a reagent widely used in organic synthesis. This carbonate ester reacts with amines to give N-tert-butoxycarbonyl or so-called Boc derivatives. These derivatives do not behave as amines, which allows certain subsequent transformations to occur that would have otherwise affected the amine functional group. The Boc can later be removed from the amine using acids. Thus, Boc serves as a protective group, for instance in solid phase peptide synthesis. It is unreactive to most bases and nucleophiles, allowing for an orthogonal Fluorenylmethyloxycarbonyl chloride (FMOC-Cl) protection.
| Appearance & Physical State | White to off-white microcrystalline powder
| Density | 0.95 g/mL at 25 °C(lit.)
| Melting Point | 23 °C(lit.)
| Boiling Point | 65-67 °C
| Flash Point | 99 °F
| Refractive Index | n20/D 1.409(lit.)
| Storage Condition | 2-8°C |
Product Name: Di-tert-butyl dicarbonate Synonyms: (BOC)2O;(BOC)2O FLUKA;BOC;BOC ANHYDRIDE;DI-T-BUTYL DICARBONATE;DI-T-BUTYL PYROCARBONATE;DI-TERT-BUTYL PYROCARBONATE;DI-TERT-BUTYL DICARBONATE CAS: 24424-99-5 MF: C10H18O5 MW: 218.25 EINECS: 246-240-1 mp 23 °C(lit.) bp 65-67 °C density 0.95 g/mL at 25 °C(lit.) refractive index n20/D 1.409(lit.) Fp 99 °F storage temp. 2-8°C Sensitive Moisture Sensitive BRN 1911173 Chemical Properties White to off-white microcrystalline powder Usage Reagent commonly used in organic chemistry for the introduction of the BOC protecting group.
Product Name: Di-tert-butyl dicarbonate Synonyms: (BOC)2O;(BOC)2O FLUKA;BOC;BOC ANHYDRIDE;DI-T-BUTYL DICARBONATE;DI-T-BUTYL PYROCARBONATE;DI-TERT-BUTYL PYROCARBONATE;DI-TERT-BUTYL DICARBONATE CAS: 24424-99-5 MF: C10H18O5 MW: 218.25 EINECS: 246-240-1 mp 23 °C(lit.) bp 65-67 °C density 0.95 g/mL at 25 °C(lit.) refractive index n20/D 1.409(lit.) Fp 99 °F storage temp. 2-8°C Sensitive Moisture Sensitive BRN 1911173 Chemical Properties White to off-white microcrystalline powder Usage Reagent commonly used in organic chemistry for the introduction of the BOC protecting group.
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Last update 2024-05-03
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