BGC > Product Search > SHP099 | 1801747-42-1

Molecular Formula: C16H19Cl2N5
Molecular Weight: 352.26156

Molecular Formula: C16H19Cl2N5
Molecular Weight: 352.26156

Description :
SHP099 is a potent, selective, orally bioavailable, and efficacious SHP2 inhibitor (IC50 value 0.071 μM) that stabilizes SHP2 in an auto-inhibited conformation. SHP099 suppresses signaling through the Ras-ERK pathway and blocks the proliferation of receptor tyrosine kinase-driven human cancer cells in vitro and in vivo.

• Molecular Weight :352.26
• Boiling Point :530.4±50.0 °C at 760 Torr

Molecular Formula :
C16H19Cl2N5
Canonical SMILES :
NC1=NC(N2CCC(C)(N)CC2)=CN=C1C3=CC=CC(Cl)=C3Cl
InChI :
1S/C16H19Cl2N5/c1-16(20)5-7-23(8-6-16)12-9-21-14(15(19)22-12)10-3-2-4-11(17)13(10)18/h2-4,9H,5-8,20H2,1H3,(H2,19,22)
InChIKey :
YGUFCDOEKKVKJK-UHFFFAOYSA-N
Appearance :
Solid powder
Storage : Store in a cool and dry place (or refer to the Certificate of Analysis).
Synonyms :
6-(4-amino-4-methylpiperidin-1-yl)-3-(2,3-dichlorophenyl)pyrazin-2-amine; SHP099; SHP-099; SHP 099.

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