BGC > Product Search > FLI-06 | 313967-18-9

Molecular Formula: C25H30N2O5
Molecular Weight: 438.5161
UN Number: 3077
WGKGermany: 3
HS Code: 29339900

It is a new inhibitor targeting the Notch signaling pathway with an EC50 of 2.3 μ M.
Appearance	white to beige powder
Purity	98% min

It is a new inhibitor targeting the Notch signaling pathway with an EC50 of 2.3 μ M.
Appearance	white to beige powder
Purity	98% min

It is a new inhibitor targeting the Notch signaling pathway with an EC50 of 2.3 μ M.
Appearance	white to beige powder
Purity	98% min

Description :
FLI-06 is a Notch inhibitor that disrupts Notch trafficking and processing and reduces amyloid β secretion. It was shown to suppress proliferation and induce apoptosis and cell cycle arrest by targeting LSD1 and Notch pathway in esophageal squamous cell carcinoma cells.

• Molecular Weight :438.524
• Purity :> 98%

Molecular Formula :
C25H30N2O5
Canonical SMILES :
CC1=C(C(C2=C(N1)CC(CC2=O)(C)C)C3=CC=C(C=C3)[N+](=O)[O-])C(=O)OC4CCCCC4
InChI :
InChI=1S/C25H30N2O5/c1-15-21(24(29)32-18-7-5-4-6-8-18)22(16-9-11-17(12-10-16)27(30)31)23-19(26-15)13-25(2,3)14-20(23)28/h9-12,18,22,26H,4-8,13-14H2,1-3H3
InChIKey :
SWWVFYHSSOWZMF-UHFFFAOYSA-N
Solubility :
Soluble to 100 mM in DMSO, to 20 mM in ethanol.
Appearance :
White Solid
Storage : Store in a cool and dry place and at 0 - 4℃ for short term (days to weeks) or -43℃ for long term (months to years).
Synonyms :
FLI 06; cyclohexyl 2,7,7-trimethyl-4-(4-nitrophenyl)-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate

More details are to be found here

Description :
FLI-06 is a Notch inhibitor that disrupts Notch trafficking and processing and reduces amyloid β secretion. It was shown to suppress proliferation and induce apoptosis and cell cycle arrest by targeting LSD1 and Notch pathway in esophageal squamous cell carcinoma cells.

• Molecular Weight :438.524
• Purity :> 98%

Molecular Formula :
C25H30N2O5
Canonical SMILES :
CC1=C(C(C2=C(N1)CC(CC2=O)(C)C)C3=CC=C(C=C3)[N+](=O)[O-])C(=O)OC4CCCCC4
InChI :
InChI=1S/C25H30N2O5/c1-15-21(24(29)32-18-7-5-4-6-8-18)22(16-9-11-17(12-10-16)27(30)31)23-19(26-15)13-25(2,3)14-20(23)28/h9-12,18,22,26H,4-8,13-14H2,1-3H3
InChIKey :
SWWVFYHSSOWZMF-UHFFFAOYSA-N
Solubility :
Soluble to 100 mM in DMSO, to 20 mM in ethanol.
Appearance :
White Solid
Storage : Store in a cool and dry place and at 0 - 4℃ for short term (days to weeks) or -43℃ for long term (months to years).
Synonyms :
FLI 06; cyclohexyl 2,7,7-trimethyl-4-(4-nitrophenyl)-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate

More details are to be found here