BGC > Product Search > Exatecan mesylate

Molecular Formula: C25H26FN3O7S
Molecular Weight: 531.5532432

Molecular Formula: C25H30FN3O9S
Molecular Weight: 567.5838032

Molecular Formula: C25H30FN3O9S
Molecular Weight: 567.5838032

Description :
Exatecan mesylate is a semisynthetic, water-soluble derivative of camptothecin with antineoplastic activity. Exatecan mesylate inhibits topoisomerase I activity by stabilizing the cleavable complex between topoisomerase I and DNA and inhibiting the religation of DNA breaks, thereby inhibiting DNA replication and triggering apoptotic cell death. This agent does not require enzymatic activation and exhibits greater potency than camptothecin and other camptothecin analogs.

• Molecular Weight :531.56
• Melting Point :> 137°C (dec.)
• Purity :> 98%

Molecular Formula :
C25H26FN3O7S
Canonical SMILES :
CCC1(C2=C(COC1=O)C(=O)N3CC4=C5C(CCC6=C5C(=CC(=C6C)F)N=C4C3=C2)N)O.CS(=O)(=O)O
InChI :
InChI=1S/C24H22FN3O4.CH4O3S/c1-3-24(31)14-6-18-21-12(8-28(18)22(29)13(14)9-32-23(24)30)19-16(26)5-4-11-10(2)15(25)7-17(27-21)20(11)19;1-5(2,3)4/h6-7,16,31H,3-5,8-9,26H2,1-2H3;1H3,(H,2,3,4)/t16-,24-;/m0./s1
InChIKey :
BICYDYDJHSBMFS-GRGFAMGGSA-N
Solubility :
Soluble in DMSO (Slightly), Methanol (Slightly, Heated, Sonicated), Water (Slightly, Heated)
Appearance :
Pale Yellow to Yellow Solid
Storage : Store at 2-8°C under inert atmosphere
Synonyms :
DX 8951 mesylate; (1S,9S)-1-Amino-9-ethyl-5-fluoro-1,2,3,9,12,15-hexahydro-9-hydroxy-4-methyl-10H,13H-benzo(de)pyrano(3',4':6,7)indolizino(1,2-b)quinoline-10,13-dione mesylate; 10H,13H-Benzo(de)pyrano(3',4':6,7)indolizino(1,2-b)quinoline-10,13-dione, 1-amino-9-ethyl-5-fluoro-1,2,3,9,12,15-hexahydro-9-hydroxy-4-methyl-, (1S-trans)-, mesylate (1:1); NSC-829066 mesylate

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