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Suppliers for
Darunavir
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Properties | CAS |
206361-99-1 | Formula |
C27H37N3O7S |
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15 Registered suppliers
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Molecular Formula: C27H37N3O7S Molecular Weight: 547.66 WGKGermany: 3
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Molecular Formula: C27H37N3O7S Molecular Weight: 547.66 WGKGermany: 3
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Description : Darunavir is a second generation protease inhibitor that targets the HIV-1 protease. It demonstrates extremely potent activity against the infectivity and replication of various strains of HIV-1, including several that are resistant to first generation protease inhibitors (IC50s = 3-30 nM). Darunavir has been reported to inhibit both cell-free diffusion and cell-to-cell spread of HIV-1 with IC50 values of 2.5 and 2.8 nM, respectively. - Molecular Weight :547.67
- Melting Point :> 90°C (dec.)
- Purity :≥98%
Molecular Formula : C27H37N3O7S Canonical SMILES : CC(C)CN(CC(C(CC1=CC=CC=C1)NC(=O)OC2COC3C2CCO3)O)S(=O)(=O)C4=CC=C(C=C4)N InChI : InChI=1S/C27H37N3O7S/c1-18(2)15-30(38(33,34)21-10-8-20(28)9-11-21)16-24(31)23(14-19-6-4-3-5-7-19)29-27(32)37-25-17-36-26-22(25)12-13-35-26/h3-11,18,22-26,31H,12-17,28H2,1-2H3,(H,29,32)/t22-,23-,24+,25-,26+/m0/s1 InChIKey : CJBJHOAVZSMMDJ-HEXNFIEUSA-N Solubility : In Vitro: DMSO : ≥ 100 mg/mL(182.60 mM) In Vivo: 1.Add each solvent one by one:10% DMSO > > 40%PEG300 > > 5%Tween-80 > > 45% saline Solubility: ≥ 2.5 mg/mL (4.56 mM); Clear solution 2.Add each solvent one by one:10% DMSO > > 90% (20%SBE-β-CDin saline) Solubility: ≥ 2.5 mg/mL (4.56 mM); Clear solution 3.Add each solvent one by one:10% DMSO > > 90%corn oil Solubility: ≥ 2.5 mg/mL (4.56 mM); Clear solution Appearance : White to Pale Beige Solid Application : HIV Protease Inhibitors Storage : Powder: -20°C: 3 years 4°C: 2 years In solvent: -80°C: 6 months -20°C: 1 month Synonyms : TMC-114; TMC 114; TMC114; Prezista
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Purity : 98% Smile code : O=C(O[C@@H]1[C@@]2([H])[C@@](OCC2)([H])OC1)N[C@@H](CC3=CC=CC=C3)[C@H](O)CN(S(=O)(C4=CC=C(N)C=C4)=O)CC(C)C MDL Number : MFCD09260006 MolFormula : C27H37N3O7S MolWeight : 547.6636 Available in stock : 159.931
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Purity : 98% Smile code : O=C(O[C@@H]1[C@@]2([H])[C@@](OCC2)([H])OC1)N[C@@H](CC3=CC=CC=C3)[C@H](O)CN(S(=O)(C4=CC=C(N)C=C4)=O)CC(C)C MDL Number : MFCD09260006 MolFormula : C27H37N3O7S MolWeight : 547.6636 Available in stock : 159.931
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Detailed information on the suppliers of
Darunavir
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Properties:
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Last update 2024-06-18
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