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Suppliers for
Netupitant
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Properties | | CAS |
290297-26-6 | | Formula |
C30H32F6N4O |
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8 Registered suppliers
Molecular Formula: C30H32F6N4O Molecular Weight: 578.59
More details are to be found here
Molecular Formula: C30H32F6N4O Molecular Weight: 578.59
More details are to be found here
Molecular Formula: C30H32F6N4O Molecular Weight: 578.59
More details are to be found here
Molecular Formula: C30H32F6N4O Molecular Weight: 578.59
More details are to be found here
Description : Netupitant is a selective neurokinin 1 (NK1) receptor antagonist with potential antiemetic activity. Netupitant competitively binds to and blocks the human substance P/NK1 receptors in the central nervous system (CNS), thereby inhibiting NK1-receptor binding of the endogenous tachykinin neuropeptide substance P (SP), which may result in the prevention of chemotherapy-induced nausea and vomiting (CINV). SP is found in neurons of vagal afferent fibers innervating the brain-stem nucleus tractus solitarii and the area postrema, which contains the chemoreceptor trigger zone (CTZ), and may be elevated in response to chemotherapy. The NK-receptor is a G-protein receptor coupled to the inositol phosphate signal-transduction pathway and is found in both the nucleus tractus solitarii and the area postrema. On 10/10 2014 FDA approved netupitant for the treatment of nausea and vomiting in patients undergoing cancer chemotherapy. - Molecular Weight :578.603
- Melting Point :158-161 °C
- Purity :> 98%
Molecular Formula : C30H32F6N4O Canonical SMILES : CC1=CC=CC=C1C2=CC(=NC=C2N(C)C(=O)C(C)(C)C3=CC(=CC(=C3)C(F)(F)F)C(F)(F)F)N4CCN(CC4)C
InChI :
InChI=1S/C30H32F6N4O/c1-19-8-6-7-9-23(19)24-17-26(40-12-10-38(4)11-13-40)37-18-25(24)39(5)27(41)28(2,3)20-14-21(29(31,32)33)16-22(15-20)30(34,35)36/h6-9,14-18H,10-13H2,1-5H3
InChIKey :
WAXQNWCZJDTGBU-UHFFFAOYSA-N
Appearance :
Solid powder
Synonyms :
AGE94200; AGE-94200; AGE 94200;Ro 67-3189; Ro-67-3189; Ro67-3189; CHEBI441603; CID6451149; D05152; UNII-7732P08TIR, CHEMBL206253, AG-E-94200, Netupitant
More details are to be found here
Purity : 98% Smile code : O=C(N(C)C1=C(C2=CC=CC=C2C)C=C(N3CCN(C)CC3)N=C1)C(C)(C)C4=CC(C(F)(F)F)=CC(C(F)(F)F)=C4
MDL Number : MFCD25976831
MolFormula : C30H32F6N4O
MolWeight : 578.5917
Available in stock : 89.509
More details are to be found here
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Netupitant |
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Last update 2024-05-23
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