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Suppliers for

Purmorphamine

Properties

CAS   483367-10-8 
Formula   C31H32N6O2 

Structure

6 Registered suppliers

rd Leap Chem Co., Ltd P.R.China CD details
rd Aea.ltd P.R.China
Molecular Formula: C31H32N6O2
Molecular Weight: 520.62478
WGKGermany: 3

rd Finetech Industry Limited P.R.China CD details
rd BOC Sciences USA CD details
rd Chemos GmbH & Co. KG Germany
Description :
Purmorphamine, under the IUPAC name 9-Cyclohexyl-N-[4-(4-morpholinyl)phenyl]-2-(1-naphthalenyloxy)-9H-purin-6-amine, is a cell-permeable 6,9-trisubstituted purine which directly binds and activates Smoothened (in HEK293T cell:IC50= ~ 1.5 μM ).So it has been shown to activate the Hedgehog (Hh) signaling pathway which is important for regulating embryonic patterning, stem cell renewal, and tissue regeneration. In vitro: An activator of the hedgehog (Hh) signaling pathway by directly binds and activates Smoothened (in HEK293T cell:IC50= ~ 1.5 μM ). In vivo: Purmorphamine up-regulates ALP expression in human mesenchymal stem cell-based constructs on rats.
  • Molecular Weight :520.60
  • Boiling Point :790.3±70.0 °C at 760 mmHg
  • Purity :≥ 98.0%
Molecular Formula :
C31H32N6O2
Canonical SMILES :
C1CCC(CC1)N2C=NC3=C2N=C(N=C3NC4=CC=C(C=C4)N5CCOCC5)OC6=CC=CC7=CC=CC=C76
InChI :
1S/C31H32N6O2/c1-2-9-25(10-3-1)37-21-32-28-29(33-23-13-15-24(16-14-23)36-17-19-38-20-18-36)34-31(35-30(28)37)39-27-12-6-8-22-7-4-5-11-26(22)27/h4-8,11-16,21,25H,1-3,9-10,17-20H2,(H,33,34,35)
InChIKey :
FYBHCRQFSFYWPY-UHFFFAOYSA-N
Solubility :
DMSO: soluble5mg/mL, clear (warmed)
Appearance :
Pale beige solid
Application :
Directly binds and activates Smoothened (in HEK293T cell:IC50= ~ 1.5 μM ); An activator of the hedgehog (Hh) signaling pathway; An inducer of osteoblast differentiation (EC50= 1 μM)
Storage : -20°C Freezer
Synonyms :
9-cyclohexyl-N-(4-morpholin-4-ylphenyl)-2-naphthalen-1-yloxypurin-6-amine; purmorphamine; Purmorphamine; 483367-10-8; 2-(1-Naphthoxy)-6-(4-morpholinoanilino)-9-cyclohexylpurine; UNII-PB12M2F8KY; Shh Signaling Antagonist VI; PB12M2F8KY; CHEMBL1221984; CHEBI:63053; C31H32N6O2; IN1132; 9-cyclohexyl-N-[4-(morpholin-4-yl)phenyl]-2-(naphthalen-1-yloxy)-9H-purin-6-amine; 9-cyclohexyl-N-(4-morpholin-4-ylphenyl)-2-naphthalen-1-yloxypurin-6-amine; 9-Cyclohexyl-N-[4-(4-morpholinyl)phenyl]-2-(1-naphthalenyloxy)-9H-purin-6-amine; 9-Cyclohexyl-N-(4-(4-morpholinyl)phenyl)-2-(1-naphthalenyloxy)-9H-purin-6-amine; Purmorphamine [MI]; MolMap_000073; AC1NR49A; MLS006010334; SCHEMBL1548273; CTK1D4950; AOB5391; DTXSID20415293; FYBHCRQFSFYWPY-UHFFFAOYSA-N; HMS3650O20; BDBM50324671; HSCI1_000224; IN2207; NSC747596; ZINC14806830; AKOS024458218; 2- -6- -9-CYCLOHEXYLPURINE; CS-1135; LS41103; NSC-747596; RL03799; NCGC00344053-01; 4CA-1056; AK175828; BC600598; DA-05531; HE070984; HE345035; HY-15108; KB-80166; QC-10453; SMR004701397; AB0032036; X5299; Purmorphamine and Shh Signaling Antagonist VI; W-5393; BRD-K73397362-001-01-7; 2-(1-Napthoxy)-6-(4-morpholinoanilino)-9-cyclohexylpurine; 9-cyclohexyl-N-(4-morpholinophenyl)-2-(naphthalen-1-yloxy)-9H-purin-6-amine; 9-Cyclohexyl-N-[4-(morpholinyl)phenyl]-2-(1-naphthalenyloxy)-9H-purin-6-amine; 9H-Purin-6-amine, 9-cyclohexyl-N-(4-(4-morpholinyl)phenyl)-2-(1-naphthalenyloxy)-; 9-?CYCLOHEXYL-?N-?[4-?(MORPHOLINYL)PHENYL]-?2-?(1-?NAPHTHALENYLOXY)-?9H-?PURIN-?6-?AMINE

More details are to be found here
rd Santa Cruz Biotechnology, Inc. USA
Description :
Purmorphamine, under the IUPAC name 9-Cyclohexyl-N-[4-(4-morpholinyl)phenyl]-2-(1-naphthalenyloxy)-9H-purin-6-amine, is a cell-permeable 6,9-trisubstituted purine which directly binds and activates Smoothened (in HEK293T cell:IC50= ~ 1.5 μM ).So it has been shown to activate the Hedgehog (Hh) signaling pathway which is important for regulating embryonic patterning, stem cell renewal, and tissue regeneration. In vitro: An activator of the hedgehog (Hh) signaling pathway by directly binds and activates Smoothened (in HEK293T cell:IC50= ~ 1.5 μM ). In vivo: Purmorphamine up-regulates ALP expression in human mesenchymal stem cell-based constructs on rats.
  • Molecular Weight :520.60
  • Boiling Point :790.3±70.0 °C at 760 mmHg
  • Purity :≥ 98.0%
Molecular Formula :
C31H32N6O2
Canonical SMILES :
C1CCC(CC1)N2C=NC3=C2N=C(N=C3NC4=CC=C(C=C4)N5CCOCC5)OC6=CC=CC7=CC=CC=C76
InChI :
1S/C31H32N6O2/c1-2-9-25(10-3-1)37-21-32-28-29(33-23-13-15-24(16-14-23)36-17-19-38-20-18-36)34-31(35-30(28)37)39-27-12-6-8-22-7-4-5-11-26(22)27/h4-8,11-16,21,25H,1-3,9-10,17-20H2,(H,33,34,35)
InChIKey :
FYBHCRQFSFYWPY-UHFFFAOYSA-N
Solubility :
DMSO: soluble5mg/mL, clear (warmed)
Appearance :
Pale beige solid
Application :
Directly binds and activates Smoothened (in HEK293T cell:IC50= ~ 1.5 μM ); An activator of the hedgehog (Hh) signaling pathway; An inducer of osteoblast differentiation (EC50= 1 μM)
Storage : -20°C Freezer
Synonyms :
9-cyclohexyl-N-(4-morpholin-4-ylphenyl)-2-naphthalen-1-yloxypurin-6-amine; purmorphamine; Purmorphamine; 483367-10-8; 2-(1-Naphthoxy)-6-(4-morpholinoanilino)-9-cyclohexylpurine; UNII-PB12M2F8KY; Shh Signaling Antagonist VI; PB12M2F8KY; CHEMBL1221984; CHEBI:63053; C31H32N6O2; IN1132; 9-cyclohexyl-N-[4-(morpholin-4-yl)phenyl]-2-(naphthalen-1-yloxy)-9H-purin-6-amine; 9-cyclohexyl-N-(4-morpholin-4-ylphenyl)-2-naphthalen-1-yloxypurin-6-amine; 9-Cyclohexyl-N-[4-(4-morpholinyl)phenyl]-2-(1-naphthalenyloxy)-9H-purin-6-amine; 9-Cyclohexyl-N-(4-(4-morpholinyl)phenyl)-2-(1-naphthalenyloxy)-9H-purin-6-amine; Purmorphamine [MI]; MolMap_000073; AC1NR49A; MLS006010334; SCHEMBL1548273; CTK1D4950; AOB5391; DTXSID20415293; FYBHCRQFSFYWPY-UHFFFAOYSA-N; HMS3650O20; BDBM50324671; HSCI1_000224; IN2207; NSC747596; ZINC14806830; AKOS024458218; 2- -6- -9-CYCLOHEXYLPURINE; CS-1135; LS41103; NSC-747596; RL03799; NCGC00344053-01; 4CA-1056; AK175828; BC600598; DA-05531; HE070984; HE345035; HY-15108; KB-80166; QC-10453; SMR004701397; AB0032036; X5299; Purmorphamine and Shh Signaling Antagonist VI; W-5393; BRD-K73397362-001-01-7; 2-(1-Napthoxy)-6-(4-morpholinoanilino)-9-cyclohexylpurine; 9-cyclohexyl-N-(4-morpholinophenyl)-2-(naphthalen-1-yloxy)-9H-purin-6-amine; 9-Cyclohexyl-N-[4-(morpholinyl)phenyl]-2-(1-naphthalenyloxy)-9H-purin-6-amine; 9H-Purin-6-amine, 9-cyclohexyl-N-(4-(4-morpholinyl)phenyl)-2-(1-naphthalenyloxy)-; 9-?CYCLOHEXYL-?N-?[4-?(MORPHOLINYL)PHENYL]-?2-?(1-?NAPHTHALENYLOXY)-?9H-?PURIN-?6-?AMINE

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