BGC > Product Search > Mianserin hydrochloride

Molecular Formula: C18H21ClN2
Molecular Weight: 300.83
Hazard Symbols: Xn,Xi,T,F
UN Number: 3249
WGKGermany: 3
PackingGroup: III

Sr. No. Items Specifications Results
01. Appearance White or almost white, crystalline powder or crystals. Almost white crystalline powder
02. Identification
a. UV Absorbance at 64-72 Conforms
b. IR IR Should conforms to the standard Conforms
c. TLC The principal spot in the chromatogram obtained
with the test solution is similar in position and size to
the principal spot in the chromatogram obtained with
reference solution Conforms
03. Related substances (% Area Normalization By HPLC)
a. impurity B NMT: 0.3% 0.14%
b. impuritie A NMT: 0.15% 0.13%
c. impuritie D NMT: 0.15% N.D
d. impuritie E NMT: 0.15% N.D
e. Any single
impurity NMT: 0.10% 0.07%
f. Total impurities NMT: 0.5% 0.44%
04. PH of solution 4.0-5.5 4.7
05. Residue on
ignition NMT: 0.1% 0.06%
06. Loss on drying NMT: 0.5% 0.1%
07. Assay 98.5% to 101.0% 99.1%

Description :
Mianserin Hydrochloride is a psychoactive drug of the tetracyclic antidepressant.It is classified as a noradrenergic and specific serotonergic antidepressant (NaSSA) and has antidepressant, anxiolytic (anti-anxiety), hypnotic (sedating), antiemetic (nausea and vomiting-attenuating), orexigenic (appetite-stimulating), and antihistamine effects.It is not approved for use in the US.

• Molecular Weight :300.83
• Melting Point :> 230ºC (dec.)
• Purity :> 98%

Molecular Formula :
C18H20N2.HCl
Canonical SMILES :
CN1CCN2C(C1)C3=CC=CC=C3CC4=CC=CC=C42.Cl
InChI :
InChI=1S/C18H20N2.ClH/c1-19-10-11-20-17-9-5-3-7-15(17)12-14-6-2-4-8-16(14)18(20)13-19;/h2-9,18H,10-13H2,1H3;1H
InChIKey :
YNPFMWCWRVTGKJ-UHFFFAOYSA-N
Solubility :
> 45.1 [ug/mL] (The mean of the results at pH 7.4)
Appearance :
Off-White Solid
Application :
Antidepressive Agents, Second-Generation
Synonyms :
ORG GB-94 HCl; Mianserin hydrochloride; Tolvon; Tolvin; ORG GB 94; Lerivon.

More details are to be found here

Description :
Mianserin Hydrochloride is a psychoactive drug of the tetracyclic antidepressant.It is classified as a noradrenergic and specific serotonergic antidepressant (NaSSA) and has antidepressant, anxiolytic (anti-anxiety), hypnotic (sedating), antiemetic (nausea and vomiting-attenuating), orexigenic (appetite-stimulating), and antihistamine effects.It is not approved for use in the US.

• Molecular Weight :300.83
• Melting Point :> 230ºC (dec.)
• Purity :> 98%

Molecular Formula :
C18H20N2.HCl
Canonical SMILES :
CN1CCN2C(C1)C3=CC=CC=C3CC4=CC=CC=C42.Cl
InChI :
InChI=1S/C18H20N2.ClH/c1-19-10-11-20-17-9-5-3-7-15(17)12-14-6-2-4-8-16(14)18(20)13-19;/h2-9,18H,10-13H2,1H3;1H
InChIKey :
YNPFMWCWRVTGKJ-UHFFFAOYSA-N
Solubility :
> 45.1 [ug/mL] (The mean of the results at pH 7.4)
Appearance :
Off-White Solid
Application :
Antidepressive Agents, Second-Generation
Synonyms :
ORG GB-94 HCl; Mianserin hydrochloride; Tolvon; Tolvin; ORG GB 94; Lerivon.

More details are to be found here

Description :
Mianserin Hydrochloride is a psychoactive drug of the tetracyclic antidepressant.It is classified as a noradrenergic and specific serotonergic antidepressant (NaSSA) and has antidepressant, anxiolytic (anti-anxiety), hypnotic (sedating), antiemetic (nausea and vomiting-attenuating), orexigenic (appetite-stimulating), and antihistamine effects.It is not approved for use in the US.

• Molecular Weight :300.83
• Melting Point :> 230ºC (dec.)
• Purity :> 98%

Molecular Formula :
C18H20N2.HCl
Canonical SMILES :
CN1CCN2C(C1)C3=CC=CC=C3CC4=CC=CC=C42.Cl
InChI :
InChI=1S/C18H20N2.ClH/c1-19-10-11-20-17-9-5-3-7-15(17)12-14-6-2-4-8-16(14)18(20)13-19;/h2-9,18H,10-13H2,1H3;1H
InChIKey :
YNPFMWCWRVTGKJ-UHFFFAOYSA-N
Solubility :
> 45.1 [ug/mL] (The mean of the results at pH 7.4)
Appearance :
Off-White Solid
Application :
Antidepressive Agents, Second-Generation
Synonyms :
ORG GB-94 HCl; Mianserin hydrochloride; Tolvon; Tolvin; ORG GB 94; Lerivon.

More details are to be found here

Description :
Mianserin Hydrochloride is a psychoactive drug of the tetracyclic antidepressant.It is classified as a noradrenergic and specific serotonergic antidepressant (NaSSA) and has antidepressant, anxiolytic (anti-anxiety), hypnotic (sedating), antiemetic (nausea and vomiting-attenuating), orexigenic (appetite-stimulating), and antihistamine effects.It is not approved for use in the US.

• Molecular Weight :300.83
• Melting Point :> 230ºC (dec.)
• Purity :> 98%

Molecular Formula :
C18H20N2.HCl
Canonical SMILES :
CN1CCN2C(C1)C3=CC=CC=C3CC4=CC=CC=C42.Cl
InChI :
InChI=1S/C18H20N2.ClH/c1-19-10-11-20-17-9-5-3-7-15(17)12-14-6-2-4-8-16(14)18(20)13-19;/h2-9,18H,10-13H2,1H3;1H
InChIKey :
YNPFMWCWRVTGKJ-UHFFFAOYSA-N
Solubility :
> 45.1 [ug/mL] (The mean of the results at pH 7.4)
Appearance :
Off-White Solid
Application :
Antidepressive Agents, Second-Generation
Synonyms :
ORG GB-94 HCl; Mianserin hydrochloride; Tolvon; Tolvin; ORG GB 94; Lerivon.

More details are to be found here