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Suppliers for
Larotaxel
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Properties | CAS |
156294-36-9 | Formula |
C45H53NO14 |
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6 Registered suppliers
Molecular Formula: C45H53NO14 Molecular Weight: 831.90062
Molecular Formula: C45H53NO14 Molecular Weight: 831.90062
Molecular Formula: C45H53NO14 Molecular Weight: 831.90062
Description : Larotaxel is a semi-synthetic derivative of the taxane 10-deacetylbaccatin III with potential antineoplastic activities. Larotaxel binds to tubulin, promoting microtubule assembly and stabilization and preventing microtubule depolymerization, thereby inhibiting cell proliferation. As it represents poor substrate for P-glycoprotein-related drug resistance mechanisms, this agent may be useful for treating multi-drug resistant tumors. Larotaxel penetrates the blood brain barrier. - Molecular Weight :831.912
- Boiling Point :889.3±65.0 °C at 760 mmHg
- Melting Point :170-174°C (dec.)
Molecular Formula : C45H53NO14 Canonical SMILES : CC1=C2C(C(=O)C34CC3CC5C(C4C(C(C2(C)C)(CC1OC(=O)C(C(C6=CC=CC=C6)NC(=O)OC(C)(C)C)O)O)OC(=O)C7=CC=CC=C7)(CO5)OC(=O)C)OC(=O)C InChI : InChI=1S/C45H53NO14/c1-23-29(57-39(52)33(49)32(26-15-11-9-12-16-26)46-40(53)60-41(4,5)6)21-45(54)37(58-38(51)27-17-13-10-14-18-27)35-43(36(50)34(56-24(2)47)31(23)42(45,7)8)20-28(43)19-30-44(35,22-55-30)59-25(3)48/h9-18,28-30,32-35,37,49,54H,19-22H2,1-8H3,(H,46,53)/t28-,29+,30-,32+,33-,34-,35+,37+,43-,44+,45-/m1/s1 InChIKey : DXOJIXGRFSHVKA-BZVZGCBYSA-N Solubility : Soluble in Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly) Appearance : White to Off-white Solid Storage : Store at -20°C Synonyms : XRP9881; PNU 100940
More details are to be found here
Description : Larotaxel is a semi-synthetic derivative of the taxane 10-deacetylbaccatin III with potential antineoplastic activities. Larotaxel binds to tubulin, promoting microtubule assembly and stabilization and preventing microtubule depolymerization, thereby inhibiting cell proliferation. As it represents poor substrate for P-glycoprotein-related drug resistance mechanisms, this agent may be useful for treating multi-drug resistant tumors. Larotaxel penetrates the blood brain barrier. - Molecular Weight :831.912
- Boiling Point :889.3±65.0 °C at 760 mmHg
- Melting Point :170-174°C (dec.)
Molecular Formula : C45H53NO14 Canonical SMILES : CC1=C2C(C(=O)C34CC3CC5C(C4C(C(C2(C)C)(CC1OC(=O)C(C(C6=CC=CC=C6)NC(=O)OC(C)(C)C)O)O)OC(=O)C7=CC=CC=C7)(CO5)OC(=O)C)OC(=O)C InChI : InChI=1S/C45H53NO14/c1-23-29(57-39(52)33(49)32(26-15-11-9-12-16-26)46-40(53)60-41(4,5)6)21-45(54)37(58-38(51)27-17-13-10-14-18-27)35-43(36(50)34(56-24(2)47)31(23)42(45,7)8)20-28(43)19-30-44(35,22-55-30)59-25(3)48/h9-18,28-30,32-35,37,49,54H,19-22H2,1-8H3,(H,46,53)/t28-,29+,30-,32+,33-,34-,35+,37+,43-,44+,45-/m1/s1 InChIKey : DXOJIXGRFSHVKA-BZVZGCBYSA-N Solubility : Soluble in Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly) Appearance : White to Off-white Solid Storage : Store at -20°C Synonyms : XRP9881; PNU 100940
More details are to be found here
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Larotaxel
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Last update 2024-06-04
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