BGC > Product Search > glaucocalyxin A

Molecular Formula: C20H28O4
Molecular Weight: 332.437

Molecular Formula: C20H28O4
Molecular Weight: 332.437

Description :
Glaucocalyxin A, which is extracted from the herbs of Rabdosia rubescens, inhibited Akt phosphorylation, suppressed proliferation, and promoted apoptosis in a dose-dependent manner, but not in normal glial cells. Glaucocalyxin A activated caspase-3, decreased BAD phosphorylation, and reduced the expression of X-linked inhibitor of apoptosis protein. Glaucocalyxin A inhibited collagen-stimulated tyrosine phosphorylation of Syk, LAT, and phospholipase Cγ2, the signaling events in collagen receptor GPⅥ pathway.

• Molecular Weight :332.43
• Purity :> 98%

Molecular Formula :
C20H28O4
Canonical SMILES :
CC1(C2CC(C34C(C2(CCC1=O)C)CCC(C3O)C(=C)C4=O)O)C
InChI :
InChI=1S/C20H28O4/c1-10-11-5-6-12-19(4)8-7-14(21)18(2,3)13(19)9-15(22)20(12,16(10)23)17(11)24/h11-13,15,17,22,24H,1,5-9H2,2-4H3/t11-,12-,13+,15+,17+,19-,20-/m0/s1
InChIKey :
UCDVIBNDYLUWFP-MJTHGBBVSA-N
Appearance :
White powder
Application :
Antiplatelet/antithrombotic
Synonyms :
LeukaMenin F; Wangzaozin B; Leucamenin F

More details are to be found here

Description :
Glaucocalyxin A, which is extracted from the herbs of Rabdosia rubescens, inhibited Akt phosphorylation, suppressed proliferation, and promoted apoptosis in a dose-dependent manner, but not in normal glial cells. Glaucocalyxin A activated caspase-3, decreased BAD phosphorylation, and reduced the expression of X-linked inhibitor of apoptosis protein. Glaucocalyxin A inhibited collagen-stimulated tyrosine phosphorylation of Syk, LAT, and phospholipase Cγ2, the signaling events in collagen receptor GPⅥ pathway.

• Molecular Weight :332.43
• Purity :> 98%

Molecular Formula :
C20H28O4
Canonical SMILES :
CC1(C2CC(C34C(C2(CCC1=O)C)CCC(C3O)C(=C)C4=O)O)C
InChI :
InChI=1S/C20H28O4/c1-10-11-5-6-12-19(4)8-7-14(21)18(2,3)13(19)9-15(22)20(12,16(10)23)17(11)24/h11-13,15,17,22,24H,1,5-9H2,2-4H3/t11-,12-,13+,15+,17+,19-,20-/m0/s1
InChIKey :
UCDVIBNDYLUWFP-MJTHGBBVSA-N
Appearance :
White powder
Application :
Antiplatelet/antithrombotic
Synonyms :
LeukaMenin F; Wangzaozin B; Leucamenin F

More details are to be found here