BGC > Product Search > RO1138452 | 221529-58-4

Molecular Formula: C19H23N3O
Molecular Weight: 309.41

Description :
RO1138452 is one of the most potent high-affinity ligands and functional antagonists for the human IP (prostacyclin) receptor. It exhibits no affinity at other prostanoid receptors (EP1-4, FP and TP) in a radioligand binding assay. RO1138452 antagonizes the carbaprostacyclin-induced activation of human neuroblastoma adenylate cyclase, blocking cyclic AMP accumulation in a dose-dependent manner.

• Molecular Weight :309.413

Molecular Formula :
C19H23N3O
Canonical SMILES :
CC(C)OC1=CC=C(C=C1)CC2=CC=C(C=C2)NC3=NCCN3
InChI :
InChI=1S/C19H23N3O/c1-14(2)23-18-9-5-16(6-10-18)13-15-3-7-17(8-4-15)22-19-20-11-12-21-19/h3-10,14H,11-13H2,1-2H3,(H2,20,21,22)
InChIKey :
GYYRMJMXXLJZAB-UHFFFAOYSA-N
Synonyms :
RO-1138452; RO1138452; RO 1138452; CAY10441; CAY-10441; CAY 10441; N-(4-(4-Isopropoxybenzyl)phenyl)-4,5-dihydro-1H-imidazol-2-amine

More details are to be found here

Description :
RO1138452 is one of the most potent high-affinity ligands and functional antagonists for the human IP (prostacyclin) receptor. It exhibits no affinity at other prostanoid receptors (EP1-4, FP and TP) in a radioligand binding assay. RO1138452 antagonizes the carbaprostacyclin-induced activation of human neuroblastoma adenylate cyclase, blocking cyclic AMP accumulation in a dose-dependent manner.

• Molecular Weight :309.413

Molecular Formula :
C19H23N3O
Canonical SMILES :
CC(C)OC1=CC=C(C=C1)CC2=CC=C(C=C2)NC3=NCCN3
InChI :
InChI=1S/C19H23N3O/c1-14(2)23-18-9-5-16(6-10-18)13-15-3-7-17(8-4-15)22-19-20-11-12-21-19/h3-10,14H,11-13H2,1-2H3,(H2,20,21,22)
InChIKey :
GYYRMJMXXLJZAB-UHFFFAOYSA-N
Synonyms :
RO-1138452; RO1138452; RO 1138452; CAY10441; CAY-10441; CAY 10441; N-(4-(4-Isopropoxybenzyl)phenyl)-4,5-dihydro-1H-imidazol-2-amine

More details are to be found here