Description :
Sephin 1 is a selective PPP1R15A inhibitor devoid of PPP1R15B and α2-adrenergic activity. In cells, Sephin 1 selectively disrupted the PPP1R15A-PP1c complex, thus prolonging eIF2α phosphorylation after stress, delaying translation recovery, and attenuated expression of stress genes such as the pro-apoptotic protein CHOP. In mice, Sephin 1 safely prevented the motor, morphological, and molecular defects of two otherwise unrelated protein-misfolding diseases.
- Molecular Weight :196.64
- Purity :99%
Molecular Formula :
C8H9ClN4
Canonical SMILES :
C1=CC=C(C(=C1)C=NN=C(N)N)Cl
InChI :
InChI=1S/C8H9ClN4/c9-7-4-2-1-3-6(7)5-12-13-8(10)11/h1-5H,(H4,10,11,13)/b12-5+
InChIKey :
PDWJALXSRRSUHR-LFYBBSHMSA-N
Solubility :
24.8 [ug/mL] (The mean of the results at pH 7.4)
Application :
potential treatment of protein misfolding disease
Synonyms :
Sephin1; Sephin-1
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