|
Suppliers for CAS
639089-54-6
|
Properties | | CAS |
639089-54-6 | | Formula |
C23H28N8OS |
|
|
9 Registered suppliers
Simagchem Corporation
P.R.China
H&Z Industry Co.,Ltd
P.R.China
Capot Chemical Co., Ltd.
P.R.China
More details are to be found here
Leap Chem Co., Ltd
P.R.China
Molecular Formula: C23H28N8OS
Molecular Weight: 464.59
Aea.ltd
P.R.China
Molecular Formula: C23H28N8OS
Molecular Weight: 464.59
Molecular Formula: C23H28N8OS
Molecular Weight: 464.59
Molecular Formula: C23H28N8OS
Molecular Weight: 464.59
Hangzhou Zhongqi Chem Co., Ltd
P.R.China
Molecular Formula: C23H28N8OS
Molecular Weight: 464.59
Skyrun Industrial Co., Ltd.
P.R.China
Molecular Formula: C23H28N8OS
Molecular Weight: 464.59
BOC Sciences
USA
Description : The Aurora kinases (A, B, and C) are a family of serine-threonine kinases that regulate various stages of mitotic function. With significant roles in cell cycle and cell division, Aurora kinase gene amplification and overexpression are linked to tumorigenesis. MK 0457 is a potent pan-Aurora kinase inhibitor but favors Aurora A (Ki = 0.6 nM) over Aurora B (Ki = 18 nM) or Aurora C (Ki = 4.6 nM). It shows selectivity against a panel of more than 190 different protein kinases. MK 0457 effectively inhibits proliferation of several different cell lines of clear cell renal carcinoma (IC50s < 10 µM) and blocks the growth of tumors in a rodent model of cancer (80 mg/kg), inhibiting histone H3 phosphorylation and increasing apoptosis. By depleting Aurora activity, MK 0457 disrupts bipolar spindle formation during mitosis, arresting cell cycle progression at the G2/M phase. Molecular Formula : C23H28N8OS Canonical SMILES : CC1=CC(=NN1)NC2=NC(=NC(=C2)N3CCN(CC3)C)SC4=CC=C(C=C4)NC(=O)C5CC5
InChI :
InChI=1S/C23H28N8OS/c1-15-13-20(29-28-15)25-19-14-21(31-11-9-30(2)10-12-31)27-23(26-19)33-18-7-5-17(6-8-18)24-22(32)16-3-4-16/h5-8,13-14,16H,3-4,9-12H2,1-2H3,(H,24,32)(H2,25,26,27,28,29)
InChIKey :
GCIKSSRWRFVXBI-UHFFFAOYSA-N
Appearance :
white solid powder
Synonyms :
VX680; VX 680; VX-680; MK0457; MK 0457; MK-0457; VE465; VE-465; VE 465; Tozasertib
More details are to be found here
Santa Cruz Biotechnology, Inc.
USA
Description : The Aurora kinases (A, B, and C) are a family of serine-threonine kinases that regulate various stages of mitotic function. With significant roles in cell cycle and cell division, Aurora kinase gene amplification and overexpression are linked to tumorigenesis. MK 0457 is a potent pan-Aurora kinase inhibitor but favors Aurora A (Ki = 0.6 nM) over Aurora B (Ki = 18 nM) or Aurora C (Ki = 4.6 nM). It shows selectivity against a panel of more than 190 different protein kinases. MK 0457 effectively inhibits proliferation of several different cell lines of clear cell renal carcinoma (IC50s < 10 µM) and blocks the growth of tumors in a rodent model of cancer (80 mg/kg), inhibiting histone H3 phosphorylation and increasing apoptosis. By depleting Aurora activity, MK 0457 disrupts bipolar spindle formation during mitosis, arresting cell cycle progression at the G2/M phase. Molecular Formula : C23H28N8OS Canonical SMILES : CC1=CC(=NN1)NC2=NC(=NC(=C2)N3CCN(CC3)C)SC4=CC=C(C=C4)NC(=O)C5CC5
InChI :
InChI=1S/C23H28N8OS/c1-15-13-20(29-28-15)25-19-14-21(31-11-9-30(2)10-12-31)27-23(26-19)33-18-7-5-17(6-8-18)24-22(32)16-3-4-16/h5-8,13-14,16H,3-4,9-12H2,1-2H3,(H,24,32)(H2,25,26,27,28,29)
InChIKey :
GCIKSSRWRFVXBI-UHFFFAOYSA-N
Appearance :
white solid powder
Synonyms :
VX680; VX 680; VX-680; MK0457; MK 0457; MK-0457; VE465; VE-465; VE 465; Tozasertib
More details are to be found here
Detailed information on the suppliers of
|
details
details