Suppliers for CAS
21919-05-1
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Properties | CAS |
21919-05-1 | Formula |
C9H8N4O5 |
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5 Registered suppliers
Leap Chem Co., Ltd
P.R.China
Molecular Formula: C9H8N4O5 Molecular Weight: 252.18 WGKGermany: 3
More details are to be found here
BOC Sciences
USA
Description : Tretazicar (CB1954) is a dinitrobenzamide prodrug that is converted in the presence of the enzyme NQO2 and co-substrate caricotamide (EP-0152R) (EP) into a potent cytotoxic bifunctional alkylating agent. CB1954 has been proposed for use in enzyme-prodrug gene therapy systems with the Escherichia coli enzyme nitroreductase (Ntr). Ntr converts CB1954 to 2- and 4-hydroxylamino derivatives, whereupon the non-enzymatic reaction of the 4-hydroxylamino derivative with cellular thio- esters generates a potent cytotoxic bifunctional alkylating agent capable of cross-linking DNA. Ntr delivery has been achieved in vitro using retroviral and adenoviral vectors and confirmed by immunocytochemical demonstration of Ntr expression. The Ntr-expressing cells have been shown to be sensitized to CB1954 by up to 2000-fold. The Ntr-CB1954 system shows effective bystander killing in mixed populations of Ntr-expressing and non-expressing cells treated with CB1954. The efficacy of this enzyme-prodrug approach in model systems compared with other VDEPT approaches demonstrates the feasibility and future promise of this gene therapy strategy. - Molecular Weight :252.186
- Purity :0.98
Molecular Formula : C9H8N4O5 Canonical SMILES : C1CN1C2=C(C=C(C(=C2)C(=O)N)[N+](=O)[O-])[N+](=O)[O-] InChI : InChI=1S/C9H8N4O5/c10-9(14)5-3-7(11-1-2-11)8(13(17)18)4-6(5)12(15)16/h3-4H,1-2H2,(H2,10,14) InChIKey : WOCXQMCIOTUMJV-UHFFFAOYSA-N Appearance : white solid powder Application : Antineoplastic Agents Synonyms : CB1954; CB-1954; CB 1954; Tretazicar.
More details are to be found here
BLD Pharmatech Ltd
P.R.China
Smile code: O=C(N)C1=CC(N2CC2)=C([N+]([O-])=O)C=C1[N+]([O-])=O MDL Number: MFCD00869490 Purity : 98% Available in stock: 10.648 g
More details are to be found here
Chemlyte Solutions
P.R.China
More details are to be found here
Santa Cruz Biotechnology, Inc.
USA
More details are to be found here
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