Suppliers for CAS
1073154-85-4
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Properties | CAS |
1073154-85-4 | Formula |
C20H21F3N8O3S |
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4 Registered suppliers
Amadis Chemical Company Limited
P.R.China
More details are to be found here
Leap Chem Co., Ltd
P.R.China
Molecular Formula: C20H21F3N8O3S Molecular Weight: 510.4927496
Aea.ltd
P.R.China
Molecular Formula: C20H21F3N8O3S Molecular Weight: 510.4927496
Molecular Formula: C20H21F3N8O3S Molecular Weight: 510.4927496
BOC Sciences
USA
Description : Defactinib, also known as VS-6063 and PF-04554878, is an orally bioavailable, small-molecule focal adhesion kinase (FAK) inhibitor with potential antiangiogenic and antineoplastic activities. FAK inhibitor PF-04554878 inhibits FAK, which may prevent the integrin-mediated activation of several downstream signal transduction pathways, including ERK, JNK/MAPK and PI3K/Akt, thus inhibiting tumor cell migration, proliferation and survival. The tyrosine kinase FAK is , a signal transducer for integrins that is upregulated in many tumor cell types and is involved in tumor cell invasion, migration and proliferation. - Molecular Weight :510.496
- Purity :> 98%
Molecular Formula : C20H21F3N8O3S Canonical SMILES : CNC(=O)C1=CC=C(C=C1)NC2=NC=C(C(=N2)NCC3=NC=CN=C3N(C)S(=O)(=O)C)C(F)(F)F InChI : InChI=1S/C20H21F3N8O3S/c1-24-18(32)12-4-6-13(7-5-12)29-19-28-10-14(20(21,22)23)16(30-19)27-11-15-17(26-9-8-25-15)31(2)35(3,33)34/h4-10H,11H2,1-3H3,(H,24,32)(H2,27,28,29,30) InChIKey : FWLMVFUGMHIOAA-UHFFFAOYSA-N Appearance : White Solid Powder Synonyms : N-methyl-4-((4-(((3-(N-methylmethylsulfonamido)pyrazin-2-yl)methyl)amino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)benzamide; VS6063; VS 6063; VS-6063; PF04554878; PF-04554878; PF 04554878; PF4554878; PF-4554878
More details are to be found here
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