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104344-23-2



 

Properties

CAS   104344-23-2 
Formula   C18H31NO4.C4H4O4 

Structure

Star Bisoprolol fumarate
Star product of Arevipharma GmbH

19 Registered suppliers

Sancai Industry Co.,Ltd. P.R.China
rd Bisoprolol fumarate   CD details
Hangzhou Keying Chem Co., Ltd. P.R.China
rd Bisoprolol fumarate  
Appearance White crystals or a white crystalline powder
Identification 1) Corresponds to that of Bisoprolol Fumarate reference standard.
2) The retention time of the major peak in the chromatofram of the Assay preparation corresponds to that in the chromatogram of the Standard preparation as obtained in the Assay.
Specific rotation -2°~ +2°
Water determination ≤ 0.5%
Reside on ignition ≤ 0.1%
Heavy metals ≤ 0.002%
Chromatographic purity Total impurities ≤ 0.5%
Content of Fumaric Acid 14.8 ~ 15.4% calculated on the anhydrous basis
Residual Solvents
2-propanol ≤ 5000ppm
Epichlorohydrin ≤ 100ppm
Benzene ≤ 2ppm
Methanol ≤ 3000ppm
Methyl tertbutyl ether ≤ 5000ppm
Ethanol ≤ 5000ppm
Ethyl acetate ≤ 5000ppm
Assay 97.5% ~ 102.0% calculated on the anhydrous basis

H&Z Industry Co.,Ltd P.R.China
rd Bisoprolol fumarate  
Appearance White crystals or a white crystalline powder
Identification 1) Corresponds to that of Bisoprolol Fumarate reference standard.
2) The retention time of the major peak in the chromatofram of the Assay preparation corresponds to that in the chromatogram of the Standard preparation as obtained in the Assay.
Specific rotation -2°~ +2°
Water determination ≤ 0.5%
Reside on ignition ≤ 0.1%
Heavy metals ≤ 0.002%
Chromatographic purity Total impurities ≤ 0.5%
Content of Fumaric Acid 14.8 ~ 15.4% calculated on the anhydrous basis
Residual Solvents
2-propanol ≤ 5000ppm
Epichlorohydrin ≤ 100ppm
Benzene ≤ 2ppm
Methanol ≤ 3000ppm
Methyl tertbutyl ether ≤ 5000ppm
Ethanol ≤ 5000ppm
Ethyl acetate ≤ 5000ppm
Assay 97.5% ~ 102.0% calculated on the anhydrous basis

Xingrui Industry Co., Limited P.R.China
rd Bisoprolol fumarate  
Appearance White crystals or a white crystalline powder
Identification 1) Corresponds to that of Bisoprolol Fumarate reference standard.
2) The retention time of the major peak in the chromatofram of the Assay preparation corresponds to that in the chromatogram of the Standard preparation as obtained in the Assay.
Specific rotation -2°~ +2°
Water determination ≤ 0.5%
Reside on ignition ≤ 0.1%
Heavy metals ≤ 0.002%
Chromatographic purity Total impurities ≤ 0.5%
Content of Fumaric Acid 14.8 ~ 15.4% calculated on the anhydrous basis
Residual Solvents
2-propanol ≤ 5000ppm
Epichlorohydrin ≤ 100ppm
Benzene ≤ 2ppm
Methanol ≤ 3000ppm
Methyl tertbutyl ether ≤ 5000ppm
Ethanol ≤ 5000ppm
Ethyl acetate ≤ 5000ppm
Assay 97.5% ~ 102.0% calculated on the anhydrous basis

Hangzhou Meite Industry Co., Ltd (Hangzhou Meite Chemical Co., Ltd) P.R.China
rd Bisoprolol fumarate  
Appearance White crystals or a white crystalline powder
Identification 1) Corresponds to that of Bisoprolol Fumarate reference standard.
2) The retention time of the major peak in the chromatofram of the Assay preparation corresponds to that in the chromatogram of the Standard preparation as obtained in the Assay.
Specific rotation -2°~ +2°
Water determination ≤ 0.5%
Reside on ignition ≤ 0.1%
Heavy metals ≤ 0.002%
Chromatographic purity Total impurities ≤ 0.5%
Content of Fumaric Acid 14.8 ~ 15.4% calculated on the anhydrous basis
Residual Solvents
2-propanol ≤ 5000ppm
Epichlorohydrin ≤ 100ppm
Benzene ≤ 2ppm
Methanol ≤ 3000ppm
Methyl tertbutyl ether ≤ 5000ppm
Ethanol ≤ 5000ppm
Ethyl acetate ≤ 5000ppm
Assay 97.5% ~ 102.0% calculated on the anhydrous basis

Leap Chem Co., Ltd P.R.China
rd Bisoprolol fumarate   CD details
Sigma-Aldrich International GmbH Switzerland
rd Bisoprolol fumarate  
Molecular Formula: C22H35NO8
Molecular Weight: 441.5152
More details are to be found here
Jai Radhe Sales India
rd Bisoprolol fumarate  
Molecular Formula: C22H35NO8
Molecular Weight: 441.5152
More details are to be found here
Newstar Chem Enterprise Ltd. P.R.China
rd Bisoprolol fumarate  
Molecular Formula: C22H35NO8
Molecular Weight: 441.5152
More details are to be found here
Hangzhou Lingrui Chemical Co., Ltd. P.R.China
rd Bisoprolol fumarate  
Molecular Formula: C22H35NO8
Molecular Weight: 441.5152
More details are to be found here
Skyrun Industrial Co., Ltd. P.R.China
rd Bisoprolol fumarate  
Molecular Formula: C22H35NO8
Molecular Weight: 441.5152
More details are to be found here
BOC Sciences USA
rd Bisoprolol hemifumarate   CD details
Shandong SanYoung Industry Co., Ltd P.R.China
rd Bisoprolol fumarate  
Description :
Bisoprolol is a beta-adrenoceptor blocking drug (beta-blocker). More specifically, it is a selective type β1 adrenergic receptor blocker.
  • Molecular Weight :383.48
  • Melting Point :99-102°C
  • Purity :> 98%
Molecular Formula :
C18H31NO4.1/2(C4H4O4)
Canonical SMILES :
CC(C)NCC(COC1=CC=C(C=C1)COCCOC(C)C)O.CC(C)NCC(COC1=CC=C(C=C1)COCCOC(C)C)O.C(=CC(=O)O)C(=O)O
InChI :
InChI=1S/2C18H31NO4.C4H4O4/c2*1-14(2)19-11-17(20)13-23-18-7-5-16(6-8-18)12-21-9-10-22-15(3)4;5-3(6)1-2-4(7)8/h2*5-8,14-15,17,19-20H,9-13H2,1-4H3;1-2H,(H,5,6)(H,7,8)/b;;2-1+
InChIKey :
VMDFASMUILANOL-WXXKFALUSA-N
Solubility :
Soluble in Chloroform (Slightly), Ethanol, Methanol (Slightly)
Appearance :
White to Off-white Solid
Application :
Antihypertensive Agents
Storage : Store at 2-8°C
Synonyms :
1-[4-[[2-(1-Methylethoxy)ethoxy]methyl]phenoxy]-3-[(1-methylethyl)amino]-2-propanol hemifumarate; Bisoprolol Fumarate; Concor; Detensiel; Emcor; Euradial; Isoten; Monocor; Soprol; Zebeta; Fondril; (+/-)-Bisoprolol hemifumarate; 2-Propanol, 1-[4-[[2-(1-methylethoxy)ethoxy]methyl]phenoxy]-3-[(1-methylethyl)amino]-, (2E)-2-butenedioate (2:1); 2-Propanol, 1-[4-[[2-(1-methylethoxy)ethoxy]methyl]phenoxy]-3-[(1-methylethyl)amino]-, (E)-2-butenedioate (2:1) (salt); 2-Propanol, 1-[4-[[2-(1-methylethoxy)ethoxy]methyl]phenoxy]-3-[(1-methylethyl)amino]-, (±)-, (E)-2-butenedioate (2:1) (salt); 1-(4-((2-Isopropoxyethoxy)methyl)phenoxy)-3-(isopropylamino)propan-2-ol hemifumarate; EMD 33512; Emvoncor; Maintate
More details are to be found here
Xiamen Equation Chemical Co.,Ltd P.R.China
rd Bisoprolol hemifumarate  
Description :
Bisoprolol is a beta-adrenoceptor blocking drug (beta-blocker). More specifically, it is a selective type β1 adrenergic receptor blocker.
  • Molecular Weight :383.48
  • Melting Point :99-102°C
  • Purity :> 98%
Molecular Formula :
C18H31NO4.1/2(C4H4O4)
Canonical SMILES :
CC(C)NCC(COC1=CC=C(C=C1)COCCOC(C)C)O.CC(C)NCC(COC1=CC=C(C=C1)COCCOC(C)C)O.C(=CC(=O)O)C(=O)O
InChI :
InChI=1S/2C18H31NO4.C4H4O4/c2*1-14(2)19-11-17(20)13-23-18-7-5-16(6-8-18)12-21-9-10-22-15(3)4;5-3(6)1-2-4(7)8/h2*5-8,14-15,17,19-20H,9-13H2,1-4H3;1-2H,(H,5,6)(H,7,8)/b;;2-1+
InChIKey :
VMDFASMUILANOL-WXXKFALUSA-N
Solubility :
Soluble in Chloroform (Slightly), Ethanol, Methanol (Slightly)
Appearance :
White to Off-white Solid
Application :
Antihypertensive Agents
Storage : Store at 2-8°C
Synonyms :
1-[4-[[2-(1-Methylethoxy)ethoxy]methyl]phenoxy]-3-[(1-methylethyl)amino]-2-propanol hemifumarate; Bisoprolol Fumarate; Concor; Detensiel; Emcor; Euradial; Isoten; Monocor; Soprol; Zebeta; Fondril; (+/-)-Bisoprolol hemifumarate; 2-Propanol, 1-[4-[[2-(1-methylethoxy)ethoxy]methyl]phenoxy]-3-[(1-methylethyl)amino]-, (2E)-2-butenedioate (2:1); 2-Propanol, 1-[4-[[2-(1-methylethoxy)ethoxy]methyl]phenoxy]-3-[(1-methylethyl)amino]-, (E)-2-butenedioate (2:1) (salt); 2-Propanol, 1-[4-[[2-(1-methylethoxy)ethoxy]methyl]phenoxy]-3-[(1-methylethyl)amino]-, (±)-, (E)-2-butenedioate (2:1) (salt); 1-(4-((2-Isopropoxyethoxy)methyl)phenoxy)-3-(isopropylamino)propan-2-ol hemifumarate; EMD 33512; Emvoncor; Maintate
More details are to be found here
AK Scientific, Inc. USA
rd Bisoprolol hemifumarate  
Description :
Bisoprolol is a beta-adrenoceptor blocking drug (beta-blocker). More specifically, it is a selective type β1 adrenergic receptor blocker.
  • Molecular Weight :383.48
  • Melting Point :99-102°C
  • Purity :> 98%
Molecular Formula :
C18H31NO4.1/2(C4H4O4)
Canonical SMILES :
CC(C)NCC(COC1=CC=C(C=C1)COCCOC(C)C)O.CC(C)NCC(COC1=CC=C(C=C1)COCCOC(C)C)O.C(=CC(=O)O)C(=O)O
InChI :
InChI=1S/2C18H31NO4.C4H4O4/c2*1-14(2)19-11-17(20)13-23-18-7-5-16(6-8-18)12-21-9-10-22-15(3)4;5-3(6)1-2-4(7)8/h2*5-8,14-15,17,19-20H,9-13H2,1-4H3;1-2H,(H,5,6)(H,7,8)/b;;2-1+
InChIKey :
VMDFASMUILANOL-WXXKFALUSA-N
Solubility :
Soluble in Chloroform (Slightly), Ethanol, Methanol (Slightly)
Appearance :
White to Off-white Solid
Application :
Antihypertensive Agents
Storage : Store at 2-8°C
Synonyms :
1-[4-[[2-(1-Methylethoxy)ethoxy]methyl]phenoxy]-3-[(1-methylethyl)amino]-2-propanol hemifumarate; Bisoprolol Fumarate; Concor; Detensiel; Emcor; Euradial; Isoten; Monocor; Soprol; Zebeta; Fondril; (+/-)-Bisoprolol hemifumarate; 2-Propanol, 1-[4-[[2-(1-methylethoxy)ethoxy]methyl]phenoxy]-3-[(1-methylethyl)amino]-, (2E)-2-butenedioate (2:1); 2-Propanol, 1-[4-[[2-(1-methylethoxy)ethoxy]methyl]phenoxy]-3-[(1-methylethyl)amino]-, (E)-2-butenedioate (2:1) (salt); 2-Propanol, 1-[4-[[2-(1-methylethoxy)ethoxy]methyl]phenoxy]-3-[(1-methylethyl)amino]-, (±)-, (E)-2-butenedioate (2:1) (salt); 1-(4-((2-Isopropoxyethoxy)methyl)phenoxy)-3-(isopropylamino)propan-2-ol hemifumarate; EMD 33512; Emvoncor; Maintate
More details are to be found here
Chemos GmbH & Co. KG Germany
rd Bisoprolol fumarate  
Description :
Bisoprolol is a beta-adrenoceptor blocking drug (beta-blocker). More specifically, it is a selective type β1 adrenergic receptor blocker.
  • Molecular Weight :383.48
  • Melting Point :99-102°C
  • Purity :> 98%
Molecular Formula :
C18H31NO4.1/2(C4H4O4)
Canonical SMILES :
CC(C)NCC(COC1=CC=C(C=C1)COCCOC(C)C)O.CC(C)NCC(COC1=CC=C(C=C1)COCCOC(C)C)O.C(=CC(=O)O)C(=O)O
InChI :
InChI=1S/2C18H31NO4.C4H4O4/c2*1-14(2)19-11-17(20)13-23-18-7-5-16(6-8-18)12-21-9-10-22-15(3)4;5-3(6)1-2-4(7)8/h2*5-8,14-15,17,19-20H,9-13H2,1-4H3;1-2H,(H,5,6)(H,7,8)/b;;2-1+
InChIKey :
VMDFASMUILANOL-WXXKFALUSA-N
Solubility :
Soluble in Chloroform (Slightly), Ethanol, Methanol (Slightly)
Appearance :
White to Off-white Solid
Application :
Antihypertensive Agents
Storage : Store at 2-8°C
Synonyms :
1-[4-[[2-(1-Methylethoxy)ethoxy]methyl]phenoxy]-3-[(1-methylethyl)amino]-2-propanol hemifumarate; Bisoprolol Fumarate; Concor; Detensiel; Emcor; Euradial; Isoten; Monocor; Soprol; Zebeta; Fondril; (+/-)-Bisoprolol hemifumarate; 2-Propanol, 1-[4-[[2-(1-methylethoxy)ethoxy]methyl]phenoxy]-3-[(1-methylethyl)amino]-, (2E)-2-butenedioate (2:1); 2-Propanol, 1-[4-[[2-(1-methylethoxy)ethoxy]methyl]phenoxy]-3-[(1-methylethyl)amino]-, (E)-2-butenedioate (2:1) (salt); 2-Propanol, 1-[4-[[2-(1-methylethoxy)ethoxy]methyl]phenoxy]-3-[(1-methylethyl)amino]-, (±)-, (E)-2-butenedioate (2:1) (salt); 1-(4-((2-Isopropoxyethoxy)methyl)phenoxy)-3-(isopropylamino)propan-2-ol hemifumarate; EMD 33512; Emvoncor; Maintate
More details are to be found here
BuGuCh & Partners Germany
rd Bisoprolol hemifumarate  
Description :
Bisoprolol is a beta-adrenoceptor blocking drug (beta-blocker). More specifically, it is a selective type β1 adrenergic receptor blocker.
  • Molecular Weight :383.48
  • Melting Point :99-102°C
  • Purity :> 98%
Molecular Formula :
C18H31NO4.1/2(C4H4O4)
Canonical SMILES :
CC(C)NCC(COC1=CC=C(C=C1)COCCOC(C)C)O.CC(C)NCC(COC1=CC=C(C=C1)COCCOC(C)C)O.C(=CC(=O)O)C(=O)O
InChI :
InChI=1S/2C18H31NO4.C4H4O4/c2*1-14(2)19-11-17(20)13-23-18-7-5-16(6-8-18)12-21-9-10-22-15(3)4;5-3(6)1-2-4(7)8/h2*5-8,14-15,17,19-20H,9-13H2,1-4H3;1-2H,(H,5,6)(H,7,8)/b;;2-1+
InChIKey :
VMDFASMUILANOL-WXXKFALUSA-N
Solubility :
Soluble in Chloroform (Slightly), Ethanol, Methanol (Slightly)
Appearance :
White to Off-white Solid
Application :
Antihypertensive Agents
Storage : Store at 2-8°C
Synonyms :
1-[4-[[2-(1-Methylethoxy)ethoxy]methyl]phenoxy]-3-[(1-methylethyl)amino]-2-propanol hemifumarate; Bisoprolol Fumarate; Concor; Detensiel; Emcor; Euradial; Isoten; Monocor; Soprol; Zebeta; Fondril; (+/-)-Bisoprolol hemifumarate; 2-Propanol, 1-[4-[[2-(1-methylethoxy)ethoxy]methyl]phenoxy]-3-[(1-methylethyl)amino]-, (2E)-2-butenedioate (2:1); 2-Propanol, 1-[4-[[2-(1-methylethoxy)ethoxy]methyl]phenoxy]-3-[(1-methylethyl)amino]-, (E)-2-butenedioate (2:1) (salt); 2-Propanol, 1-[4-[[2-(1-methylethoxy)ethoxy]methyl]phenoxy]-3-[(1-methylethyl)amino]-, (±)-, (E)-2-butenedioate (2:1) (salt); 1-(4-((2-Isopropoxyethoxy)methyl)phenoxy)-3-(isopropylamino)propan-2-ol hemifumarate; EMD 33512; Emvoncor; Maintate
More details are to be found here
Arevipharma GmbH Germany
rd Bisoprolol hemifumarate  
Description :
Bisoprolol is a beta-adrenoceptor blocking drug (beta-blocker). More specifically, it is a selective type β1 adrenergic receptor blocker.
  • Molecular Weight :383.48
  • Melting Point :99-102°C
  • Purity :> 98%
Molecular Formula :
C18H31NO4.1/2(C4H4O4)
Canonical SMILES :
CC(C)NCC(COC1=CC=C(C=C1)COCCOC(C)C)O.CC(C)NCC(COC1=CC=C(C=C1)COCCOC(C)C)O.C(=CC(=O)O)C(=O)O
InChI :
InChI=1S/2C18H31NO4.C4H4O4/c2*1-14(2)19-11-17(20)13-23-18-7-5-16(6-8-18)12-21-9-10-22-15(3)4;5-3(6)1-2-4(7)8/h2*5-8,14-15,17,19-20H,9-13H2,1-4H3;1-2H,(H,5,6)(H,7,8)/b;;2-1+
InChIKey :
VMDFASMUILANOL-WXXKFALUSA-N
Solubility :
Soluble in Chloroform (Slightly), Ethanol, Methanol (Slightly)
Appearance :
White to Off-white Solid
Application :
Antihypertensive Agents
Storage : Store at 2-8°C
Synonyms :
1-[4-[[2-(1-Methylethoxy)ethoxy]methyl]phenoxy]-3-[(1-methylethyl)amino]-2-propanol hemifumarate; Bisoprolol Fumarate; Concor; Detensiel; Emcor; Euradial; Isoten; Monocor; Soprol; Zebeta; Fondril; (+/-)-Bisoprolol hemifumarate; 2-Propanol, 1-[4-[[2-(1-methylethoxy)ethoxy]methyl]phenoxy]-3-[(1-methylethyl)amino]-, (2E)-2-butenedioate (2:1); 2-Propanol, 1-[4-[[2-(1-methylethoxy)ethoxy]methyl]phenoxy]-3-[(1-methylethyl)amino]-, (E)-2-butenedioate (2:1) (salt); 2-Propanol, 1-[4-[[2-(1-methylethoxy)ethoxy]methyl]phenoxy]-3-[(1-methylethyl)amino]-, (±)-, (E)-2-butenedioate (2:1) (salt); 1-(4-((2-Isopropoxyethoxy)methyl)phenoxy)-3-(isopropylamino)propan-2-ol hemifumarate; EMD 33512; Emvoncor; Maintate
More details are to be found here
Santa Cruz Biotechnology, Inc. USA
rd Bisoprolol hemifumarate  
Description :
Bisoprolol is a beta-adrenoceptor blocking drug (beta-blocker). More specifically, it is a selective type β1 adrenergic receptor blocker.
  • Molecular Weight :383.48
  • Melting Point :99-102°C
  • Purity :> 98%
Molecular Formula :
C18H31NO4.1/2(C4H4O4)
Canonical SMILES :
CC(C)NCC(COC1=CC=C(C=C1)COCCOC(C)C)O.CC(C)NCC(COC1=CC=C(C=C1)COCCOC(C)C)O.C(=CC(=O)O)C(=O)O
InChI :
InChI=1S/2C18H31NO4.C4H4O4/c2*1-14(2)19-11-17(20)13-23-18-7-5-16(6-8-18)12-21-9-10-22-15(3)4;5-3(6)1-2-4(7)8/h2*5-8,14-15,17,19-20H,9-13H2,1-4H3;1-2H,(H,5,6)(H,7,8)/b;;2-1+
InChIKey :
VMDFASMUILANOL-WXXKFALUSA-N
Solubility :
Soluble in Chloroform (Slightly), Ethanol, Methanol (Slightly)
Appearance :
White to Off-white Solid
Application :
Antihypertensive Agents
Storage : Store at 2-8°C
Synonyms :
1-[4-[[2-(1-Methylethoxy)ethoxy]methyl]phenoxy]-3-[(1-methylethyl)amino]-2-propanol hemifumarate; Bisoprolol Fumarate; Concor; Detensiel; Emcor; Euradial; Isoten; Monocor; Soprol; Zebeta; Fondril; (+/-)-Bisoprolol hemifumarate; 2-Propanol, 1-[4-[[2-(1-methylethoxy)ethoxy]methyl]phenoxy]-3-[(1-methylethyl)amino]-, (2E)-2-butenedioate (2:1); 2-Propanol, 1-[4-[[2-(1-methylethoxy)ethoxy]methyl]phenoxy]-3-[(1-methylethyl)amino]-, (E)-2-butenedioate (2:1) (salt); 2-Propanol, 1-[4-[[2-(1-methylethoxy)ethoxy]methyl]phenoxy]-3-[(1-methylethyl)amino]-, (±)-, (E)-2-butenedioate (2:1) (salt); 1-(4-((2-Isopropoxyethoxy)methyl)phenoxy)-3-(isopropylamino)propan-2-ol hemifumarate; EMD 33512; Emvoncor; Maintate
More details are to be found here
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