BGC > Product Search > DAPT

Molecular Formula: C23H26F2N2O4
Molecular Weight: 432.464
WGKGermany: 3
HS Code: 29242990

Molecular Formula: C23H26F2N2O4
Molecular Weight: 432.464
WGKGermany: 3
HS Code: 29242990

Molecular Formula: C23H26F2N2O4
Molecular Weight: 432.464
WGKGermany: 3
HS Code: 29242990

Description :
DAPT, also called γ-Secretase Inhibitor IX, is a potent and selective inhibitor of γ-secretase which leads to a reduction in Aβ40 and Aβ42 levels in human primary neuronal cultures (total Aβ: IC50 = 115 nM (human); Aβ42: IC50 = 200 nM (human)).

• Molecular Weight :432.46
• Boiling Point :612.2℃ at 760 mmHg
• Purity :0.98

Molecular Formula :
C23H26F2N2O4
Canonical SMILES :
CC(C(=O)NC(C1=CC=CC=C1)C(=O)OC(C)(C)C)NC(=O)CC2=CC(=CC(=C2)F)F
InChI :
1S/C23H26F2N2O4/c1-14(26-19(28)12-15-10-17(24)13-18(25)11-15)21(29)27-20(16-8-6-5-7-9-16)22(30)31-23(2,3)4/h5-11,13-14,20H,12H2,1-4H3,(H,26,28)(H,27,29)/t14-,20-/m0/s1
InChIKey :
DWJXYEABWRJFSP-XOBRGWDASA-N
Solubility :
Soluble to 15 mg/mL in DMSO, to ~1 mg/mL in ethanol, in dichloromethane, to ~25 mg/mL in DMF, and to ~0.1 mg/mL in 1:9 solution of DMF:PBS(pH 7.2)
Appearance :
White solid
Application :
Differentiation
Storage : Store in a cool and dry place and at 0 - 4℃ for short term (days to weeks) or -24℃ for long term (months to years).
Synonyms :
tert-butyl (2S)-2-[[(2S)-2-[[2-(3,5-difluorophenyl)acetyl]amino]propanoyl]amino]-2-phenylacetate; dapt; 208255-80-5; DAPT (GSI-IX); gamma-Secretase Inhibitor IX; CHEBI:86193; MFCD04974585; DAPT, GSI-IX; InSolution™ gamma-Secretase Inhibitor IX; N-[N-(3,5-Difluorophenacetyl-L-alanyl)]-S-phenylglycine t-Butyl Ester; N-[(3,5-Difluorophenyl)acetyl]-L-alanyl-2-phenyl]glycine-1,1-dimethylethyl ester(DAPT); C23H26F2N2O4; GSIIX; S2215_Selleck; AC1NSKCB; PubChem22436; GSI-IX; DAPT,GSI-IX; DAPT; DAPT - GSI-IX; MLS006010075; CHEMBL255682; QCR-29; SCHEMBL1360313; DTXSID00415519; AOB33372; DAPT-Supplied by Selleck Chemicals; EBD16444; ZINC1549363; ABP000317; ZINC01549363; AKOS024457209; CS-0264; NCGC00167803-03; (3,5-Difluorophenylacetyl)-Ala-Phg-OtBu; AC-23163; AK477268; BC649954; CJ-24363; HY-13027; KB-57235; SMR004701228; AB0033805; LS-191073; D4257; GSI-IX, 208255-80-5; X7572; W-5319; AB01566837_01; GSI-IX , GSI IX; 208255-80-5; N-[N-(3,5-difluorophenylacetyl)-L-alanyl]-(S)-phenylglycine t-butyl ester; DAPT|N-[(3,5-Difluorophenyl)acetyl]-L-alanyl-2-phenyl]glycine-1,1-dimethylethyl ester; N-[(3,5-Difluorophenyl)acetyl]-[l-alanyl-2-phenyl]glycine-1,1-dimethylethyl ester; N-[N-(3,5-difluorophenylacetyl)-L-alanyl]-(S)-phenylglycine t-butyl ester

More details are to be found here

Description :
DAPT, also called γ-Secretase Inhibitor IX, is a potent and selective inhibitor of γ-secretase which leads to a reduction in Aβ40 and Aβ42 levels in human primary neuronal cultures (total Aβ: IC50 = 115 nM (human); Aβ42: IC50 = 200 nM (human)).

• Molecular Weight :432.46
• Boiling Point :612.2℃ at 760 mmHg
• Purity :0.98

Molecular Formula :
C23H26F2N2O4
Canonical SMILES :
CC(C(=O)NC(C1=CC=CC=C1)C(=O)OC(C)(C)C)NC(=O)CC2=CC(=CC(=C2)F)F
InChI :
1S/C23H26F2N2O4/c1-14(26-19(28)12-15-10-17(24)13-18(25)11-15)21(29)27-20(16-8-6-5-7-9-16)22(30)31-23(2,3)4/h5-11,13-14,20H,12H2,1-4H3,(H,26,28)(H,27,29)/t14-,20-/m0/s1
InChIKey :
DWJXYEABWRJFSP-XOBRGWDASA-N
Solubility :
Soluble to 15 mg/mL in DMSO, to ~1 mg/mL in ethanol, in dichloromethane, to ~25 mg/mL in DMF, and to ~0.1 mg/mL in 1:9 solution of DMF:PBS(pH 7.2)
Appearance :
White solid
Application :
Differentiation
Storage : Store in a cool and dry place and at 0 - 4℃ for short term (days to weeks) or -24℃ for long term (months to years).
Synonyms :
tert-butyl (2S)-2-[[(2S)-2-[[2-(3,5-difluorophenyl)acetyl]amino]propanoyl]amino]-2-phenylacetate; dapt; 208255-80-5; DAPT (GSI-IX); gamma-Secretase Inhibitor IX; CHEBI:86193; MFCD04974585; DAPT, GSI-IX; InSolution™ gamma-Secretase Inhibitor IX; N-[N-(3,5-Difluorophenacetyl-L-alanyl)]-S-phenylglycine t-Butyl Ester; N-[(3,5-Difluorophenyl)acetyl]-L-alanyl-2-phenyl]glycine-1,1-dimethylethyl ester(DAPT); C23H26F2N2O4; GSIIX; S2215_Selleck; AC1NSKCB; PubChem22436; GSI-IX; DAPT,GSI-IX; DAPT; DAPT - GSI-IX; MLS006010075; CHEMBL255682; QCR-29; SCHEMBL1360313; DTXSID00415519; AOB33372; DAPT-Supplied by Selleck Chemicals; EBD16444; ZINC1549363; ABP000317; ZINC01549363; AKOS024457209; CS-0264; NCGC00167803-03; (3,5-Difluorophenylacetyl)-Ala-Phg-OtBu; AC-23163; AK477268; BC649954; CJ-24363; HY-13027; KB-57235; SMR004701228; AB0033805; LS-191073; D4257; GSI-IX, 208255-80-5; X7572; W-5319; AB01566837_01; GSI-IX , GSI IX; 208255-80-5; N-[N-(3,5-difluorophenylacetyl)-L-alanyl]-(S)-phenylglycine t-butyl ester; DAPT|N-[(3,5-Difluorophenyl)acetyl]-L-alanyl-2-phenyl]glycine-1,1-dimethylethyl ester; N-[(3,5-Difluorophenyl)acetyl]-[l-alanyl-2-phenyl]glycine-1,1-dimethylethyl ester; N-[N-(3,5-difluorophenylacetyl)-L-alanyl]-(S)-phenylglycine t-butyl ester

More details are to be found here

Description :
DAPT, also called γ-Secretase Inhibitor IX, is a potent and selective inhibitor of γ-secretase which leads to a reduction in Aβ40 and Aβ42 levels in human primary neuronal cultures (total Aβ: IC50 = 115 nM (human); Aβ42: IC50 = 200 nM (human)).

• Molecular Weight :432.46
• Boiling Point :612.2℃ at 760 mmHg
• Purity :0.98

Molecular Formula :
C23H26F2N2O4
Canonical SMILES :
CC(C(=O)NC(C1=CC=CC=C1)C(=O)OC(C)(C)C)NC(=O)CC2=CC(=CC(=C2)F)F
InChI :
1S/C23H26F2N2O4/c1-14(26-19(28)12-15-10-17(24)13-18(25)11-15)21(29)27-20(16-8-6-5-7-9-16)22(30)31-23(2,3)4/h5-11,13-14,20H,12H2,1-4H3,(H,26,28)(H,27,29)/t14-,20-/m0/s1
InChIKey :
DWJXYEABWRJFSP-XOBRGWDASA-N
Solubility :
Soluble to 15 mg/mL in DMSO, to ~1 mg/mL in ethanol, in dichloromethane, to ~25 mg/mL in DMF, and to ~0.1 mg/mL in 1:9 solution of DMF:PBS(pH 7.2)
Appearance :
White solid
Application :
Differentiation
Storage : Store in a cool and dry place and at 0 - 4℃ for short term (days to weeks) or -24℃ for long term (months to years).
Synonyms :
tert-butyl (2S)-2-[[(2S)-2-[[2-(3,5-difluorophenyl)acetyl]amino]propanoyl]amino]-2-phenylacetate; dapt; 208255-80-5; DAPT (GSI-IX); gamma-Secretase Inhibitor IX; CHEBI:86193; MFCD04974585; DAPT, GSI-IX; InSolution™ gamma-Secretase Inhibitor IX; N-[N-(3,5-Difluorophenacetyl-L-alanyl)]-S-phenylglycine t-Butyl Ester; N-[(3,5-Difluorophenyl)acetyl]-L-alanyl-2-phenyl]glycine-1,1-dimethylethyl ester(DAPT); C23H26F2N2O4; GSIIX; S2215_Selleck; AC1NSKCB; PubChem22436; GSI-IX; DAPT,GSI-IX; DAPT; DAPT - GSI-IX; MLS006010075; CHEMBL255682; QCR-29; SCHEMBL1360313; DTXSID00415519; AOB33372; DAPT-Supplied by Selleck Chemicals; EBD16444; ZINC1549363; ABP000317; ZINC01549363; AKOS024457209; CS-0264; NCGC00167803-03; (3,5-Difluorophenylacetyl)-Ala-Phg-OtBu; AC-23163; AK477268; BC649954; CJ-24363; HY-13027; KB-57235; SMR004701228; AB0033805; LS-191073; D4257; GSI-IX, 208255-80-5; X7572; W-5319; AB01566837_01; GSI-IX , GSI IX; 208255-80-5; N-[N-(3,5-difluorophenylacetyl)-L-alanyl]-(S)-phenylglycine t-butyl ester; DAPT|N-[(3,5-Difluorophenyl)acetyl]-L-alanyl-2-phenyl]glycine-1,1-dimethylethyl ester; N-[(3,5-Difluorophenyl)acetyl]-[l-alanyl-2-phenyl]glycine-1,1-dimethylethyl ester; N-[N-(3,5-difluorophenylacetyl)-L-alanyl]-(S)-phenylglycine t-butyl ester

More details are to be found here

Description :
DAPT, also called γ-Secretase Inhibitor IX, is a potent and selective inhibitor of γ-secretase which leads to a reduction in Aβ40 and Aβ42 levels in human primary neuronal cultures (total Aβ: IC50 = 115 nM (human); Aβ42: IC50 = 200 nM (human)).

• Molecular Weight :432.46
• Boiling Point :612.2℃ at 760 mmHg
• Purity :0.98

Molecular Formula :
C23H26F2N2O4
Canonical SMILES :
CC(C(=O)NC(C1=CC=CC=C1)C(=O)OC(C)(C)C)NC(=O)CC2=CC(=CC(=C2)F)F
InChI :
1S/C23H26F2N2O4/c1-14(26-19(28)12-15-10-17(24)13-18(25)11-15)21(29)27-20(16-8-6-5-7-9-16)22(30)31-23(2,3)4/h5-11,13-14,20H,12H2,1-4H3,(H,26,28)(H,27,29)/t14-,20-/m0/s1
InChIKey :
DWJXYEABWRJFSP-XOBRGWDASA-N
Solubility :
Soluble to 15 mg/mL in DMSO, to ~1 mg/mL in ethanol, in dichloromethane, to ~25 mg/mL in DMF, and to ~0.1 mg/mL in 1:9 solution of DMF:PBS(pH 7.2)
Appearance :
White solid
Application :
Differentiation
Storage : Store in a cool and dry place and at 0 - 4℃ for short term (days to weeks) or -24℃ for long term (months to years).
Synonyms :
tert-butyl (2S)-2-[[(2S)-2-[[2-(3,5-difluorophenyl)acetyl]amino]propanoyl]amino]-2-phenylacetate; dapt; 208255-80-5; DAPT (GSI-IX); gamma-Secretase Inhibitor IX; CHEBI:86193; MFCD04974585; DAPT, GSI-IX; InSolution™ gamma-Secretase Inhibitor IX; N-[N-(3,5-Difluorophenacetyl-L-alanyl)]-S-phenylglycine t-Butyl Ester; N-[(3,5-Difluorophenyl)acetyl]-L-alanyl-2-phenyl]glycine-1,1-dimethylethyl ester(DAPT); C23H26F2N2O4; GSIIX; S2215_Selleck; AC1NSKCB; PubChem22436; GSI-IX; DAPT,GSI-IX; DAPT; DAPT - GSI-IX; MLS006010075; CHEMBL255682; QCR-29; SCHEMBL1360313; DTXSID00415519; AOB33372; DAPT-Supplied by Selleck Chemicals; EBD16444; ZINC1549363; ABP000317; ZINC01549363; AKOS024457209; CS-0264; NCGC00167803-03; (3,5-Difluorophenylacetyl)-Ala-Phg-OtBu; AC-23163; AK477268; BC649954; CJ-24363; HY-13027; KB-57235; SMR004701228; AB0033805; LS-191073; D4257; GSI-IX, 208255-80-5; X7572; W-5319; AB01566837_01; GSI-IX , GSI IX; 208255-80-5; N-[N-(3,5-difluorophenylacetyl)-L-alanyl]-(S)-phenylglycine t-butyl ester; DAPT|N-[(3,5-Difluorophenyl)acetyl]-L-alanyl-2-phenyl]glycine-1,1-dimethylethyl ester; N-[(3,5-Difluorophenyl)acetyl]-[l-alanyl-2-phenyl]glycine-1,1-dimethylethyl ester; N-[N-(3,5-difluorophenylacetyl)-L-alanyl]-(S)-phenylglycine t-butyl ester

More details are to be found here