BGC > Product Search > Chrysophanol

Appearance	Orange Powder
Odor &Taste	Characteristic
Specification	98%
Active Ingredient	Chrysophanol / Chrysophanic Acid
Sieve Analysis	NLT 100% pass 80 mesh
Loss on Drying	≤ 4.0%
Ash content	≤ 2.0%
Ethanol	<=5000ppm
Total Heavy Metals	≤ 20ppm
Total Plate Count	≤ 1000cfu/g
Total Yeast & Mold	≤ 100cfu/g

Description :
Chrysophanic acid (Chrysophanol) is a natural anthraquinone with anticancer activity in EGFR-overexpressing SNU-C5 human colon cancer cells. Chrysophanic acid preferentially blocked proliferation in SNU-C5 cells but not in other cell lines (HT7, HT29, KM12C, SW480, HCT116 and SNU-C4) with low levels of EGFR expression. Chrysophanic acid treatment in SNU-C5 cells inhibited EGF-induced phosphorylation of EGFR and suppressed activation of downstream signaling molecules, such as AKT, extracellular signal-regulated kinase (ERK) and the mammalian target of rapamycin (mTOR)/ribosomal protein S6 kinase (p70S6K). Chrysophanic acid (80 and 120 µm) significantly blocked cell proliferation when combined with the mTOR inhibitor, rapamycin. These findings offer the first evidence of anticancer activity for chrysophanic acid via EGFR/mTOR mediated signaling transduction pathway. Chrysophanol is a natural compound found in the roots and rhizomes of Rheum palmatum L. It can be used in cosmetics material.

• Molecular Weight :254.24
• Boiling Point :Sublimes
• Melting Point :194-197 ℃
• Purity :≥ 98 %

Molecular Formula :
C15H10O4
Canonical SMILES :
CC1=CC(=C2C(=C1)C(=O)C3=C(C2=O)C(=CC=C3)O)O
InChI :
InChI=1S/C15H10O4/c1-7-5-9-13(11(17)6-7)15(19)12-8(14(9)18)3-2-4-10(12)16/h2-6,16-17H,1H3
InChIKey :
LQGUBLBATBMXHT-UHFFFAOYSA-N
Solubility :
less than 1 mg/mL at 64 °F
Appearance :
Orange solid
Application :
anti-inflammatory
Synonyms :
1,8-dihydroxy-3-methylanthracene-9,10-dione

More details are to be found here

Purity : 98%
Smile code : O=C1C2=C(C=CC=C2O)C(C3=CC(C)=CC(O)=C13)=O
MDL Number : MFCD00001208
MolFormula : C15H10O4
MolWeight : 254.2375
Available in stock : 13.097