Description:
Eflornithine hydrochloride, hydrate is a drug found to be effective in the treatment of facial hirsutism. It is a ''suicide inhibitor,'' irreversibly binding to Ornithine Decarboxylase (ODC) and preventing the natural substrate ornithine from accessing the active site. It is an irreversible inhibitor of ornithine decarboxylase that suppresses polyamine biosynthesis. It displays antiangiogenic and cytostatic effects in tumor cells but must be used in combination with other chemotherapeutic agents to negate compensatory increases in polyamine content through alternate synthesis pathways. It also demonstrates antiparasitic activity in a model of C. parvum infection.
- Molecular Weight: 236.64
- Molecular Formula: C6H15ClF2N2O3
Purity: 98%
Canonical SMILES:
C(CC(C(F)F)(C(=O)O)N)CN.O.Cl
InChI:
InChI=1S/C6H12F2N2O2.ClH.H2O/c7-4(8)6(10,5(11)12)2-1-3-9;;/h4H,1-3,9-10H2,(H,11,12);1H;1H2
InChIKey: FJPAMFNRCFEGSD-UHFFFAOYSA-N
- Boiling Point: 347°C at 760mmHg
- Melting Point: >210°C (dec.)
- Solubility: Soluble in Methanol, Water
- Appearance: White to Off-White Solid
- Storage: Store at-20 °C
Synonyms:
DFMO hydrochloride hydrate; MDL-71782 hydrochloride hydrate; RMI-71782 hydrochloride hydrate; MDL 71782 hydrochloride hydrate; RMI 71782 hydrochloride hydrate; MDL71782 hydrochloride hydrate; RMI71782 hydrochloride hydrate; α-difluoromethylornithine hydrochloride hydrate; Vaniqa hydrochloride hydrate
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