Description:
BLZ945 is an orally active, potent and selective CSF-1R inhibitor, which inhibits CSF-1R activity with an IC50 of 1nM and is more than 1000-fold selective against its closest receptor tyrosine kinase homologs c-KIT and Platelet-derived Growth Factor Receptor beta (PDGFRb).
- Molecular Weight: 398.48
- Molecular Formula: C20H22N4O3S
Purity: >98%
Canonical SMILES:
CNC(=O)C1=NC=CC(=C1)OC2=CC3=C(C=C2)N=C(S3)NC4CCCCC4O
InChI:
InChI=1S/C20H22N4O3S/c1-21-19(26)16-10-13(8-9-22-16)27-12-6-7-15-18(11-12)28-20(24-15)23-14-4-2-3-5-17(14)25/h6-11,14,17,25H,2-5H2,1H3,(H,21,26)(H,23,24)/t14-,17-/m1/s1
InChIKey: ADZBMFGQQWPHMJ-RHSMWYFYSA-N
- Solubility: Soluble in DMSO, not in water
- Storage: Store at -20°C
Synonyms:
sotuletinib; BLZ 945; BLZ-945
More details are to be found on supplier website
