Description:
Tamibarotene is a retinoic acid receptor α (RARα) agonist that induces differentiation and apoptosis of HL-60 cells in vitro. It exhibits antiproliferative effects against a variety of human tumor cells lines and displays anticancer activity against acute promyelocytic leukemia in vivo. It is an orally active, synthetic retinoid, developed to overcome all-trans retinoic acid (ATRA) resistance, with potential antineoplastic activity. It may show sustained plasma levels compared to ATRA. It may exhibit a lower toxicity profile than ATRA, in part, due to the lack of affinity for the RAR-gamma receptor, the major retinoic acid receptor in the dermal epithelium.
- Molecular Weight: 351.44
- Molecular Formula: C22H25NO3
Purity: 98%
Canonical SMILES:
CC1(CCC(C2=C1C=CC(=C2)NC(=O)C3=CC=C(C=C3)C(=O)O)(C)C)C
InChI:
InChI=1S/C22H25NO3/c1-21(2)11-12-22(3,4)18-13-16(9-10-17(18)21)23-19(24)14-5-7-15(8-6-14)20(25)26/h5-10,13H,11-12H2,1-4H3,(H,23,24)(H,25,26)
InChIKey: MUTNCGKQJGXKEM-UHFFFAOYSA-N
- Boiling Point: 449.6±45.0°C (Predicted)
- Melting Point: 228-230°C
- Solubility: Soluble in DMSO (Slightly), Methanol (Slightly)
- Appearance: Off-White Solid
- Storage: Store at -20°C
Synonyms:
Retinobenzoic acid; Amnoid; AMNOLAKE; Am80; Am 80; Am-80; SY-1425; SY 1425; SY1425; Tamibarotene
More details are to be found on supplier website
