Description:
MK-4101 is a potent and selective SMO Inhibitor of the Hedgehog Pathway with anti-tumor activity. MK-4101 targets the Hh pathway in tumor cells, showing the maximum inhibitory effect on Gli1 MK-4101 also induced deregulation of cell cycle and block of DNA replication in tumors.
- Molecular Weight: 493.48
- Molecular Formula: C24H24F5N5O
Purity: >98%
Canonical SMILES:
FC(C1=CC=CC=C1C2=NN=C(C34CCC(C5=NOC(C6CC(F)(F)C6)=N5)(CC4)CC3)N2C)(F)F
InChI:
1S/C24H24F5N5O/c1-34-17(15-4-2-3-5-16(15)24(27,28)29)31-32-20(34)22-9-6-21(7-10-22,8-11-22)19-30-18(35-33-19)14-12-23(25,26)13-14/h2-5,14H,6-13H2,1H3
InChIKey: HKJOIWLYDJCTQR-UHFFFAOYSA-N
- Boiling Point: 606.1±65.0 °C at 760 Torr
- Appearance: Solid powder
- Storage: Store in a cool and dry place (or refer to the Certificate of Analysis).
Synonyms:
5-(3,3-Difluorocyclobutyl)-3-[4-[4-methyl-5-[2-(trifluoromethyl)phenyl]-4H-1,2,4-triazol-3-yl]bicyclo[2.2.2]oct-1-yl]-1,2,4-oxadiazole; MK-4101; MK 4101; MK4101.
More details are to be found on supplier website
