Description:
Ivacaftor is a potentiator of CFTR targeting G551D-CFTR(EC50=100 nM)and F508del-CFTR(EC50=25 nM). Ivacaftor is used in the treatment of cystic fibrosis.
- Molecular Weight: 392.49
- Molecular Formula: C24H28N2O3
Purity: 98%
Canonical SMILES:
CC(C)(C)C1=CC(=C(C=C1NC(=O)C2=CNC3=CC=CC=C3C2=O)O)C(C)(C)C
InChI:
InChI=1S/C24H28N2O3/c1-23(2,3)16-11-17(24(4,5)6)20(27)12-19(16)26-22(29)15-13-25-18-10-8-7-9-14(18)21(15)28/h7-13,27H,1-6H3,(H,25,28)(H,26,29)
InChIKey: PURKAOJPTOLRMP-UHFFFAOYSA-N
- Boiling Point: 550.4±50.0 °C(Predicted)
- Melting Point: 212-215°C
- Solubility: solube in DMSO, Ethyl Acetate, Methanol
- Appearance: White to Light Brown Solid
- Application: Chloride Channel Agonists
- Storage: Store at -20°C
Synonyms:
N-[2,4-Bis[1,1-di(methyl)ethyl]-5-hydroxyphenyl]-1,4-dihydro-4-oxo-3-quinolinecarboxamide; Ivacaftor; Kalydeco; VX-770; VX 770; VX770
More details are to be found on supplier website
