Description:
Cyclovirobuxine D is an active compound extracted from Buxus microphylla, which has been used for treating acute myocardial ischemia. Cyclovirobuxine D induces autophagy and attenuates the phosphorylation of Akt and mTOR. Cyclovirobuxine D inhibits cell proliferation of gastric cancer cells through suppression of cell cycle progression and inducement of mitochondria-mediated apoptosis.
- Molecular Weight: 402.66
- Molecular Formula: C26H46N2O
Purity: >98%
Canonical SMILES:
CC(C1C(CC2(C1(CCC34C2CCC5C3(C4)CCC(C5(C)C)NC)C)C)O)NC
InChI:
InChI=1S/C26H46N2O/c1-16(27-6)21-17(29)14-24(5)19-9-8-18-22(2,3)20(28-7)10-11-25(18)15-26(19,25)13-12-23(21,24)4/h16-21,27-29H,8-15H2,1-7H3/t16-,17+,18-,19-,20-,21-,23+,24-,25+,26-/m0/s1
InChIKey: GMNAPBAUIVITMI-ABNIRSKTSA-N
- Boiling Point: 495.7°C at 760 mmHg
- Melting Point: 219-222°C
- Solubility: Soluble in DMSO (<1 mg/ml at 25 °C), water (<1 mg/ml at 25 °C), and ethanol (50 mM).
- Appearance: White cryst.
- Application: Anti- oxidative/anticancer
Synonyms:
Cyclovirobuxine D; Bebuxine; CVB-D; CVB D; CVBD; NSC 91722; NSC-91722; NSC91722
More details are to be found on supplier website
