Description:
Dapsone is a sulfone active against a wide range of bacteria but mainly employed for its actions against mycobacterium leprae, which has anti-inflammatory and immunomodulatory effects. It is an antibacterial most commonly used in combination with rifampicin and clofazimine as multidrug therapy (MDT) for the treatment of Mycobacterium leprae infections (leprosy). It antagonized all of the I/R end points measured, showing a remarkable ability to decrease markers of damage through antioxidant, antiinflammatory, and anti-apoptotic effects. It also inhibits bacterial synthesis of dihydrofolic acid, via competition with para-aminobenzoate for the active site of dihydropteroate synthetase.
- Molecular Weight: 248.30
- Molecular Formula: C12H12N2O2S
Purity: > 98 %
Canonical SMILES:
C1=CC(=CC=C1N)S(=O)(=O)C2=CC=C(C=C2)N
InChI:
InChI=1S/C12H12N2O2S/c13-9-1-5-11(6-2-9)17(15,16)12-7-3-10(14)4-8-12/h1-8H,13-14H2
InChIKey: MQJKPEGWNLWLTK-UHFFFAOYSA-N
- Boiling Point: 511.7 °C at 760 mmHg
- Melting Point: 175.5 °C
- Solubility: >37.2 ug/mL
- Appearance: White crystalline powder
- Application: anti-inflammatory agent
- Storage: -20°C Freezer
Synonyms:
4-(4-aminophenyl)sulfonylaniline
More details are to be found on supplier website
